INT109967

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 15.66
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MCF-7 13
MCF7 4
fat pads 1
MDA-MB-453 1
MDA-MB-231 1
Mmv7 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 14 97.92 Very High Very High Very High
narcan 5 97.64 Very High Very High Very High
Inflammation 58 94.00 High High
opioid receptor 2 91.00 High High
metalloproteinase 16 80.24 Quite High
antagonist 13 78.60 Quite High
Pain 4 73.72 Quite High
agonist 17 57.60 Quite High
Opioid 1 48.88 Quite Low
cytokine 21 45.92 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1075 100.00 Very High Very High Very High
Breast Cancer 261 100.00 Very High Very High Very High
Carcinoma 21 100.00 Very High Very High Very High
Osteoporosis 23 99.96 Very High Very High Very High
Acidosis 4 99.62 Very High Very High Very High
Adenocarcinoma 58 99.02 Very High Very High Very High
Ovarian Cancer 34 98.72 Very High Very High Very High
Apoptosis 363 98.24 Very High Very High Very High
Metastasis 202 97.48 Very High Very High Very High
Death 78 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This cell line was designated MCF-7CLU (Figure 1 panel A).
Gene_expression (designated) of MCF-7CLU
1) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.14 Pain Relevance 0
In untransfected MCF-7 cells, TNFalpha induces the expression of p21 (Figure 3 panel A) and stimulates the proteolytic activation of Bax, an upstream regulatory protein that initiates mitochondrial membrane permeability transition and is surrogate marker for cell death.
Gene_expression (untransfected) of MCF-7 in MCF-7 associated with death
2) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.40 Pain Relevance 0
MCF-7CLU cells grow more rapidly than untransfected MCF-7 cells (Figure 2 panel A).
Gene_expression (untransfected) of MCF-7 in MCF-7
3) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.14 Pain Relevance 0
MCF-7 cells over-expressing clusterin retain their sensitivity to both estrogens and anti-estrogens as assessed by monitoring the changes in the steady state level of the estrogen target gene, pS2, by real time PCR (Figure 1 panel E).
Gene_expression (expressing) of MCF-7 in MCF-7
4) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0 Pain Relevance 0
Stable transfection of MCF-7 cells with the pEXP-CLU using the Gateway expression system resulted in the integration of approximately 1-2 copies per cell, giving rise after selection to an MCF-7 cell line constitutively expressing secretory clusterin.
Gene_expression (transfection) of MCF-7 in MCF-7
5) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.16 Pain Relevance 0
To investigate the role of secretory clusterin in the biology of breast cancer tumor growth and resistance to therapy we have engineered an MCF-7 cell line (MCF-7CLU) that over-expresses clusterin.
Gene_expression (expresses) of MCF-7CLU in MCF-7 associated with cancer and breast cancer
6) Confidence 0.27 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2856549 Disease Relevance 0.95 Pain Relevance 0
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Gene_expression (express) of MCF-7 in MCF-7 associated with narcan, death and morphine
7) Confidence 0.10 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 1.02 Pain Relevance 1.27
For example, TGZ induces cellular acidosis and decreases DNA synthesis in MCF-7 and MDA-MB-231 cells; however, GW9662 is not able to block the decreased DNA synthesis associated with TGZ-induced acidosis [28].
Gene_expression (synthesis) of MCF-7 in MDA-MB-231 associated with acidosis
8) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.56 Pain Relevance 0.04
While the magnitude of drug accumulation between the two tumor types was no different, intratumoral levels of PTX and CER from both free drug and nanoparticle administration tumors dropped drastically in the MCF7TR after 6 h to nearly entirely disappear from the tumor by 12 h after administration, whereas drug levels remained steady during this period in the MCF7 tumors.
Gene_expression (dropped) of MCF7TR in MCF7 associated with adenocarcinoma and cancer
9) Confidence 0.04 Published 2008 Journal Molecular Pharmaceutics Section Body Doc Link PMC2646668 Disease Relevance 1.60 Pain Relevance 0
For example, TGZ induces cellular acidosis and decreases DNA synthesis in MCF-7 and MDA-MB-231 cells; however, GW9662 is not able to block the decreased DNA synthesis associated with TGZ-induced acidosis [28].
Gene_expression (synthesis) of MCF-7 in MCF-7 associated with acidosis
10) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.56 Pain Relevance 0.04
Human breast adenocarcinoma (MCF7) cells and their multidrug resistant subculture MCF7TR were kindly provided by M.V.S.
Gene_expression (provided) of MCF7TR in MCF7 associated with adenocarcinoma
11) Confidence 0.03 Published 2008 Journal Molecular Pharmaceutics Section Body Doc Link PMC2646668 Disease Relevance 0.37 Pain Relevance 0
MCF-7 cells were transiently transfected with PPAR?
Gene_expression (transfected) of MCF-7 in MCF-7
12) Confidence 0.03 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2614423 Disease Relevance 0.68 Pain Relevance 0
The estrogen receptor positive human breast cancer cell line, MCF-7, has been shown to produce osteoblastic or mixed osteolytic and osteoblastic bone lesions following intracardiac inoculation in a nude mouse model.
Gene_expression (produce) of MCF-7 in MCF-7 associated with breast cancer and osteoporosis
13) Confidence 0.03 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 1.93 Pain Relevance 0
is also expressed in the breast tumor derived cancer cell lines MDA-MB-231, MCF-7, SKBR-3, MDA-MB-435, and MDA-MB-453, irrespective of ER, HER2/neu, or p53 status [13,15,16].
Gene_expression (expressed) of MCF-7 in MDA-MB-453 associated with cancer and breast cancer
14) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.98 Pain Relevance 0.08
We first used a orthotopic graft model of VEGF-C overexpressing-mammary carcinoma cells (MCF7).
Gene_expression (overexpressing) of MCF7 in MCF7 associated with carcinoma
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 1.02 Pain Relevance 0.09
To test the impact of PAI-1 on lymphatic vessel recruitment in tumors, VEGF-C-overexpressing MCF7 cells or control MCF7 cells were bilaterally injected into the fifth mammary fat pads (mfp) of immunodeficient RAG-1?
Gene_expression (overexpressing) of MCF7 in fat pads associated with cancer
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.28 Pain Relevance 0
In the present study, MCF7 cells overexpressing or not VEGF-C were inoculated into RAG-1?
Gene_expression (overexpressing) of MCF7 in MCF7
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.97 Pain Relevance 0.08
The two COX-2-overexpressing cell lines MDA-MB-231-E1A and MDA-MB-435-E1A were more sensitive to celecoxib than the corresponding control cells, but the two low-COX-2-expressing cell lines MCF-7-E1A and SKOV3.ip1-E1A were no more sensitive than control cells to celecoxib.
Gene_expression (expressing) of MCF-7 in MCF-7
18) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206712 Disease Relevance 0.80 Pain Relevance 0
We first established the cytotoxicity of celecoxib in two COX-2-overexpressing E1A-transfected breast cancer cell lines (MDA-MB-231 and MDA-MB-435) and in two low-COX-2-expressing E1A-transfected cell lines (MCF-7 (breast cancer) and SKOV3.ip1 (ovarian cancer)).
Gene_expression (expressing) of MCF-7 in MCF-7 associated with ovarian cancer and breast cancer
19) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206712 Disease Relevance 0.93 Pain Relevance 0
In their experiments, these investigators showed that in MCF-7 breast cancer cells expressing wild type p53, PTTG1 overexpression caused apoptosis.
Gene_expression (expressing) of MCF-7 in MCF-7 associated with breast cancer and apoptosis
20) Confidence 0.01 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.28 Pain Relevance 0.11

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