INT109968

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.57
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
fibroblast 4
spinal cord 2
MCF-7 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 22 99.98 Very High Very High Very High
narcan 5 96.52 Very High Very High Very High
Antinociceptive 4 96.20 Very High Very High Very High
Spinal cord 3 95.80 Very High Very High Very High
tolerance 5 95.56 Very High Very High Very High
opioid receptor 2 95.12 Very High Very High Very High
Pain 2 77.84 Quite High
Kinase C 5 74.52 Quite High
intrathecal 1 70.12 Quite High
Opioid 1 53.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 89 97.12 Very High Very High Very High
Death 63 93.12 High High
Bordatella Infection 2 91.92 High High
Stress 35 91.48 High High
Mantle-cell Lymphoma 33 90.88 High High
Adhesions 7 90.20 High High
Aging 29 89.76 High High
Apoptosis 161 88.48 High High
Injury 15 86.52 High High
Lymphatic System Cancer 122 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the increased expression and activation of p53, and the nitric oxide and caspase systems related to p53 may contribute to the development of antinociceptive tolerance to morphine in the mouse spinal cord.
Positive_regulation (increased) of Positive_regulation (activation) of p53 in spinal cord associated with tolerance, antinociceptive, spinal cord and morphine
1) Confidence 0.47 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19084050 Disease Relevance 0.13 Pain Relevance 1.11
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Positive_regulation (caused) of Positive_regulation (stabilization) of p53 in MCF-7 associated with narcan, death and morphine
2) Confidence 0.45 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 1.10 Pain Relevance 1.37
Radiation-induced activation of the P53-P21 pathway is not critical for the inhibition of endothelial sprouting
Positive_regulation (induced) of Positive_regulation (activation) of P53
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 1.05 Pain Relevance 0
Yeo et al. [24] found that HU inhibits the growth of human diploid fibroblasts by inducing increasing p53 and p21 levels in human diploid fibroblast cells.
Positive_regulation (increasing) of Positive_regulation (inducing) of p53 in fibroblast
4) Confidence 0.15 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 0 Pain Relevance 0
Yeo et al. [24] found that HU inhibits the growth of human diploid fibroblasts by inducing increasing p53 and p21 levels in human diploid fibroblast cells.
Positive_regulation (inducing) of Positive_regulation (increasing) of p53 in fibroblast
5) Confidence 0.15 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 0 Pain Relevance 0
High levels of Pim expression, as occurs in tumors, active, but not inactive, Pim-1 or Pim-2 blocks the degradation of both p53 and Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53-dependent transactivation.
Positive_regulation (leading) of Positive_regulation (increased) of p53 associated with cancer
6) Confidence 0.06 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.84 Pain Relevance 0
Decreased TrkA/PI3K/Akt signaling would also result in the activation of JNK and induction of p53 [153], as well FKH-mediated transcription [151].
Positive_regulation (activation) of Positive_regulation (induction) of p53
7) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.45 Pain Relevance 0.04

General Comments

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