INT109969

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.18
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
MCF-7 4
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 28 99.98 Very High Very High Very High
narcan 10 96.24 Very High Very High Very High
opioid receptor 4 95.12 Very High Very High Very High
Pain 2 77.84 Quite High
Opioid 2 53.00 Quite High
Disease Link Frequency Relevance Heat
Death 4 92.84 High High
Bordatella Infection 4 91.92 High High
Pain 2 77.84 Quite High
Cancer 14 75.64 Quite High
Apoptosis 6 75.00 Quite High
Adenocarcinoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Positive_regulation (stabilization) of Phosphorylation (phosphorylation) of p53 in MCF-7 associated with narcan, death and morphine
1) Confidence 0.45 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 1.09 Pain Relevance 1.35
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of p53 in MCF-7 associated with narcan, death and morphine
2) Confidence 0.45 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 1.09 Pain Relevance 1.31

General Comments

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