INT109970

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 9.34
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp8) peptidase activity (Casp8) mitochondrion (Casp8)
nucleus (Casp8) protein complex (Casp8) cytoplasm (Casp8)
Anatomy Link Frequency
nerve 1
Casp8 (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 4 99.90 Very High Very High Very High
Morphine 14 98.52 Very High Very High Very High
narcan 5 94.24 High High
Sciatic nerve 3 94.20 High High
Hyperalgesia 1 83.28 Quite High
opioid receptor 2 81.84 Quite High
Inflammation 12 79.48 Quite High
Neuropathic pain 2 79.04 Quite High
peripheral neuropathy 2 77.04 Quite High
diabetic neuropathy 2 68.16 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.90 Very High Very High Very High
Apoptosis 310 99.40 Very High Very High Very High
Diabetes Mellitus 154 98.56 Very High Very High Very High
Death 41 98.24 Very High Very High Very High
Nervous System Injury 4 97.16 Very High Very High Very High
Lymphatic System Cancer 475 96.04 Very High Very High Very High
Cancer 139 91.24 High High
Urological Neuroanatomy 6 89.12 High High
Carcinoma 19 86.00 High High
Thymoma 5 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of FLIP, caspase-8 inhibitor, enhanced NF-?
Negative_regulation (inhibitor) of caspase-8
1) Confidence 0.52 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.90 Pain Relevance 0.09
Blockade of Fas by Fas-fusion protein or inhibition of caspase 8 resulted in a partial inhibition of morphine-induced apoptosis.
Negative_regulation (inhibition) of caspase 8 associated with apoptosis and morphine
2) Confidence 0.41 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 0.97 Pain Relevance 1.26
Finally, inhibition of caspase-8 significantly decreased the dissipation of ??
Negative_regulation (inhibition) of caspase-8
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.97 Pain Relevance 0
Inhibition of caspase-8 markedly decreased apoptosis induced by Sags.
Negative_regulation (Inhibition) of caspase-8 associated with apoptosis
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.05 Pain Relevance 0
All caspase inhibitors involving a caspase-8 inhibitor completely rescued raloxifene-induced cell death.
Negative_regulation (inhibitor) of caspase-8 associated with death
5) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.96 Pain Relevance 0
Finally, the caspase-8 inhibitor was able to significantly decrease the dissipation of mitochondrial ??
Negative_regulation (inhibitor) of caspase-8
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.03 Pain Relevance 0
For caspase inhibition assays, Z-IETD-FMK caspase-8 inhibitor or Z-LEHD-FMK caspase-9 inhibitor (Calbiochem) was added one hour prior to addition of Sags.
Negative_regulation (inhibitor) of caspase-8
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.64 Pain Relevance 0
An important inhibition of specific apoptosis could be observed when T8 cells were treated with SEB in the presence of caspase-8 inhibitor (Figure 6A).
Negative_regulation (inhibitor) of caspase-8 associated with apoptosis
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.84 Pain Relevance 0
A single subcutaneous injection of ozone performed 12 h after the surgical procedure decreased mechanical allodynia and normalized the mRNA caspase-1, caspase-12 and caspase-8 gene levels, but did not the decrease caspase-3 level, 14 days post-spared nerve injury.
Negative_regulation (normalized) of caspase-8 gene in nerve associated with nervous system injury and allodynia
9) Confidence 0.14 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19100257 Disease Relevance 1.97 Pain Relevance 0.83

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