INT109971

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 13.69
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
MCF-7 2
fibroblast 2
endothelial cells 2
duodenum 2
livers 1
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 5 99.60 Very High Very High Very High
Potency 8 96.96 Very High Very High Very High
Morphine 14 95.82 Very High Very High Very High
cytokine 32 95.60 Very High Very High Very High
Hippocampus 10 93.96 High High
cINOD 10 92.20 High High
ischemia 6 88.20 High High
opioid receptor 2 86.80 High High
Glutamate 15 80.72 Quite High
Pain 4 69.52 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 233 99.72 Very High Very High Very High
Acute Erythroblastic Leukemia 2 99.70 Very High Very High Very High
Death 101 99.56 Very High Very High Very High
Cancer 536 99.04 Very High Very High Very High
Retinoblastoma 2 98.06 Very High Very High Very High
Necrosis 9 95.32 Very High Very High Very High
Intestinal Cancer 4 95.04 Very High Very High Very High
Drug Induced Neurotoxicity 2 93.20 High High
Infection 70 93.00 High High
INFLAMMATION 55 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, p21 was not induced by sulindac in the duodenal flat mucosa and tumors of Apc+/- mice in which one or both p21 alleles had been inactivated.
Neg (not) Positive_regulation (induced) of p21 associated with cancer
1) Confidence 0.69 Published 2005 Journal Oncogene Section Abstract Doc Link 15688007 Disease Relevance 0.59 Pain Relevance 0.09
In Apc+/-, p21 wild-type mice fed the sulindac supplemental diet, both p21 mRNA and protein were significantly increased in the flat mucosa and tumors of the duodenum.
Positive_regulation (increased) of p21 in duodenum associated with cancer
2) Confidence 0.69 Published 2005 Journal Oncogene Section Abstract Doc Link 15688007 Disease Relevance 0.60 Pain Relevance 0.09
In Apc+/-, p21 wild-type mice fed the sulindac supplemental diet, both p21 mRNA and protein were significantly increased in the flat mucosa and tumors of the duodenum.
Positive_regulation (increased) of p21 in duodenum associated with cancer
3) Confidence 0.50 Published 2005 Journal Oncogene Section Abstract Doc Link 15688007 Disease Relevance 0.61 Pain Relevance 0.09
We found by Northern analysis that the p53 target genes, p21 and MDM2, were induced upon MYC activation in adult livers (Figure 10C).
Positive_regulation (induced) of p21 in livers
4) Confidence 0.42 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.63 Pain Relevance 0
Taken together these results demonstrate that the P53-P21 pathway is induced upon irradiation in endothelial cells but appears not to be involved in suppressing endothelial sprouting, under the tested experimental conditions.


Positive_regulation (induced) of P21 in endothelial cells
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.12 Pain Relevance 0
Western blotting for P53, P21 and P16 proteins revealed a rapid enhancement of P53 protein followed by an increased in P21 levels, while P16 levels remained unchanged (Figure 7b).
Positive_regulation (increased) of P21
6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.59 Pain Relevance 0
Here we report that: i) High doses of ionizing radiation suppressed angiogenesis in vivo, prevented endothelial cell re-entry into the cell cycle, inhibited migration and sprouting in vitro without causing increased apoptosis. ii) P53 and P21 were activated by radiation but their absence or silencing did not prevent radiation-induced inhibition of endothelial cell sprouting or proliferation. iii) Ionizing radiation induced ALK5-dependent signaling in endothelial cells and ALK5 inhibition rescued deficient endothelial cell sprouting and migration but not proliferation in vitro, and restored angiogenesis in irradiated mice in vivo.
Positive_regulation (activated) of P21 in endothelial cells associated with apoptosis
7) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.10 Pain Relevance 0
These effects are mirrored by the abrogation of the increase in p21 levels in the nucleus and the lack of Bax cleavage in response to TNFalpha.
Positive_regulation (increase) of p21 in nucleus
8) Confidence 0.28 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.45 Pain Relevance 0.04
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Positive_regulation (increase) of p21 in MCF-7 associated with narcan, death and morphine
9) Confidence 0.23 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 0.98 Pain Relevance 1.29
Over-expression of secretory clusterin also blocks the TNFalpha-mediated induction of p21 and abrogates the cleavage of Bax to t-Bax, rendering the MCF-7CLU cells significantly more resistant to the cytokine than the parental cells.
Positive_regulation (induction) of p21 in cleavage associated with cytokine
10) Confidence 0.19 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2856549 Disease Relevance 1.05 Pain Relevance 0.05
In contrast in MCF-7 CLU cells, over-expression of secretory clusterin appears to block the effects of TNFalpha on both cell cycle (by blocking the increase in p21) and cell death by preventing the proteolytic activation of Bax (Figure 3 panel B).
Positive_regulation (increase) of p21 in MCF-7 associated with death
11) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.38 Pain Relevance 0
High fat diet activated important for cell cycle cyclin-dependent kinase inhibitors p53, p21, p16, and Ywhag.
Positive_regulation (activated) of p21 in fat
12) Confidence 0.17 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.23 Pain Relevance 0
Yeo et al. [24] found that HU inhibits the growth of human diploid fibroblasts by inducing increasing p53 and p21 levels in human diploid fibroblast cells.
Positive_regulation (inducing) of p21 in fibroblast
13) Confidence 0.16 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 0 Pain Relevance 0
Yeo et al. [24] found that HU inhibits the growth of human diploid fibroblasts by inducing increasing p53 and p21 levels in human diploid fibroblast cells.
Positive_regulation (increasing) of p21 in fibroblast
14) Confidence 0.16 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 0 Pain Relevance 0
Examination of two other genes noted to be increased early in FrCasE-infected mouse brains, C1qa and p21, did not show statistically different expression in FrCasE- versus Fr57E infected cells.
Positive_regulation (increased) of p21 in brains
15) Confidence 0.15 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.75 Pain Relevance 0.05
The roles of the activation of caspases and p21 in the process of neuronal death caused by KA insult have been reported in several studies.
Positive_regulation (activation) of p21 in neuronal associated with death
16) Confidence 0.15 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 1.09 Pain Relevance 0.28
-dependent induction of p21 through interactions with other
Positive_regulation (induction) of p21
17) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.90 Pain Relevance 0
AMPK induces upregulation of the p53–p21 axis, which leads to G1 cell cycle arrest.
Positive_regulation (upregulation) of p21
18) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.46 Pain Relevance 0.04
AICAR promotes phosphorylation of tumor suppressor p53 (Ser15 in human), subsequently leading to p21 induction.
Positive_regulation (induction) of p21 associated with cancer
19) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.57 Pain Relevance 0.04
The compound has been shown to increase the levels of p21 and to induce hyperacetylation of histone H3 and H4.
Positive_regulation (increase) of p21
20) Confidence 0.07 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.34 Pain Relevance 0.05

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