INT109972

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Context Info
Confidence 0.80
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.15
Pain Relevance 4.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
MCF-7 2
null cells 1
melanocytes 1
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 3 99.92 Very High Very High Very High
Morphine 42 99.48 Very High Very High Very High
narcan 15 99.04 Very High Very High Very High
melanocortin 1 receptor 66 96.80 Very High Very High Very High
opioid receptor 6 94.12 High High
Somatostatin 70 89.28 High High
Osteoarthritis 105 89.24 High High
Pain 7 76.84 Quite High
cINOD 5 50.00 Quite Low
cytokine 9 17.56 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 4 99.54 Very High Very High Very High
Cancer 69 99.20 Very High Very High Very High
Apoptosis 79 98.90 Very High Very High Very High
Ovarian Cancer 1 96.76 Very High Very High Very High
Death 32 95.64 Very High Very High Very High
Embryonic Lethality 2 90.96 High High
Bordatella Infection 6 90.92 High High
Osteoarthritis 108 89.24 High High
Skin Cancer 102 86.88 High High
Breast Cancer 3 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3a–d show the effects of ET-1 on the phosphorylation of p38, Akt, p44/42 and SAP/JNK kinases as detected by western blot of cell extracts.
Phosphorylation (phosphorylation) of p44
1) Confidence 0.80 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
As shown by western blot analysis of the cell extracts, incubation of cells for a short period of time with ET-1 results in the phosphorylation of p38 MAP, p44/42, SAP/JNK and Akt kinases.
Phosphorylation (phosphorylation) of p44
2) Confidence 0.80 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.09 Pain Relevance 0.04
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
Phosphorylation (phosphorylation) of p53 associated with adenocarcinoma, apoptosis and morphine
3) Confidence 0.74 Published 2003 Journal Cancer Res. Section Title Doc Link 12702572 Disease Relevance 0.93 Pain Relevance 1.12
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Phosphorylation (phosphorylation) of p53 in MCF-7 associated with narcan, death and morphine
4) Confidence 0.74 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 1.08 Pain Relevance 1.29
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Phosphorylation (phosphorylation) of p53 in MCF-7 associated with narcan, death and morphine
5) Confidence 0.73 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 1.02 Pain Relevance 1.26
ET-1 at 10 nM induced p38, Akt, p44/42, and SAP/JNK phosphorylation in a time-ordered manner.
Phosphorylation (phosphorylation) of p44
6) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.05 Pain Relevance 0
In fact, environmental factors that cause DNA damage lead to the phosphorylation of p53 which prevents a pathway required for the transcription of S-phase genes, thereby maintaining G1/S phase arrest [18].
Phosphorylation (phosphorylation) of p53
7) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.97 Pain Relevance 0.15
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Phosphorylation (phosphorylated) of p53
8) Confidence 0.26 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
From a cell-autonomous perspective, phosphorylation of p53 Ser389 is a critical and major step in triggering apoptosis in response to UV-induced DNA damage [66], and it is possible that MC1R activation (either constitutive or in response to UV radiation) plays a permissive role.
Phosphorylation (phosphorylation) of p53 associated with melanocortin 1 receptor and apoptosis
9) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.67 Pain Relevance 0.62
For example, L-type prostaglandin D2 synthase (Ptgds) is expressed at high levels in pigment cells [68] and is repressed in Mc1re/Mc1re skin (current data, [49]); prostaglandin D2 and its derivatives could be one of several mediators released from Mc1r-competent melanocytes that facilitate or potentiate p53 phosphorylation in surrounding cells [69].
Phosphorylation (phosphorylation) of p53 in melanocytes
10) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.57 Pain Relevance 0.19
Insufficient function of Ku70 might also enhance ATM-mediated signaling, as persistent phosphorylation of p53 at Ser18 by the ATM activity was observed in irradiated Ku70-deficient cells in contrast to transient activation of p53 in control cells (Tomimatsu et al., 2007).
Phosphorylation (phosphorylation) of p53
11) Confidence 0.23 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.55 Pain Relevance 0
Furthermore, a recent study has shown that in vitro, PARP-1 inhibited the activation a subset of ATM substrates such as phosphorylation of p53 on serine 15 [13].
Phosphorylation (phosphorylation) of p53
12) Confidence 0.14 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.15 Pain Relevance 0
Previous results from our group have shown that PARP-1 null cells have a deficient p53 ser15 phosphorylation in response to ionising radiation [15], confirming with a different ATM substrate that ATM activation is compromised in the absence of PARP-1.
Phosphorylation (phosphorylation) of p53 in null cells
13) Confidence 0.14 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0

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