INT109973

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.19
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.06
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf21) cytoplasm (Tnfrsf21)
Anatomy Link Frequency
MCF-7 1
cortex 1
T cells 1
hippocampus 1
Tnfrsf21 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 2 99.66 Very High Very High Very High
narcan 5 99.60 Very High Very High Very High
Morphine 14 95.82 Very High Very High Very High
cytokine 19 93.76 High High
withdrawal 2 90.56 High High
opioid receptor 2 86.80 High High
Pain 2 69.52 Quite High
Opioid 3 66.08 Quite High
Inflammation 2 43.48 Quite Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 27 100.00 Very High Very High Very High
Apoptosis 31 99.08 Very High Very High Very High
Cognitive Disorder 6 91.08 High High
Bordatella Infection 2 83.60 Quite High
Infection 78 80.88 Quite High
Cancer 8 79.52 Quite High
Adenocarcinoma 1 75.00 Quite High
Pain 1 69.52 Quite High
Sprains And Strains 2 63.52 Quite High
Atrophy 9 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects were associated with up-regulation of pro-apoptotic proteins such as Fas, FasL and Bad, in the cortex and hippocampus, indicating the activation of both the death receptor and the mitochondrial apoptotic pathways.
Positive_regulation (activation) of death receptor in hippocampus associated with hippocampus, apoptosis and death
1) Confidence 0.19 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.78 Pain Relevance 0.12
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Positive_regulation (increase) of death receptor in MCF-7 associated with narcan, death and morphine
2) Confidence 0.07 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 0.98 Pain Relevance 1.30
These effects were associated with up-regulation of pro-apoptotic proteins such as Fas, FasL and Bad, in the cortex and hippocampus, indicating the activation of both the death receptor and the mitochondrial apoptotic pathways.
Positive_regulation (activation) of death receptor in cortex associated with hippocampus, apoptosis and death
3) Confidence 0.06 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.78 Pain Relevance 0.12
In the presence of an antigen, IL-2 prompts T cells to die by AICD, through activation of death receptor molecules and caspase-8 [46]–[48].
Positive_regulation (activation) of death receptor in T cells associated with death
4) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.51 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox