INT109975

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 12.72
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Kras) mitochondrion (Kras) plasma membrane (Kras)
GTPase activity (Kras)
Anatomy Link Frequency
L929 1
pancreatic duct 1
crypt cells 1
telomere 1
Kras (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 2 98.46 Very High Very High Very High
cINOD 12 97.90 Very High Very High Very High
aspirin 6 97.56 Very High Very High Very High
Inflammation 38 96.60 Very High Very High Very High
cytokine 40 91.96 High High
melanocortin 1 receptor 1 88.88 High High
rheumatoid arthritis 149 82.24 Quite High
agonist 20 75.00 Quite High
Kinase C 21 69.16 Quite High
tolerance 2 67.52 Quite High
Disease Link Frequency Relevance Heat
Cancer 462 100.00 Very High Very High Very High
Apoptosis 51 99.90 Very High Very High Very High
Colon Cancer 47 99.56 Very High Very High Very High
Malignant Neoplastic Disease 26 99.20 Very High Very High Very High
Hyperplasia 32 98.90 Very High Very High Very High
Death 11 98.60 Very High Very High Very High
Leukemia 2 98.36 Very High Very High Very High
Endometrial Cancer 134 98.20 Very High Very High Very High
INFLAMMATION 40 96.60 Very High Very High Very High
Adenocarcinoma 65 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most common genetic aberrations in pancreatic duct cell carcinogenesis involve the activation of KRAS oncogene and inactivation of tumor suppressor genes p16/CDKN2, p53 and SMAD4/DPC4 [3].
Positive_regulation (activation) of KRAS in pancreatic duct associated with cancer
1) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.96 Pain Relevance 0
Historical research as well as current data on the significance of the hot spot mutation in BRAF is discussed in its relative potential to the activating mutation in RAS.
Positive_regulation (activating) of RAS
2) Confidence 0.30 Published 2007 Journal Mol. Carcinog. Section Abstract Doc Link 17570501 Disease Relevance 0.71 Pain Relevance 0.09
An important event in many cancer cells is the activation of endogenous oncogenes such as the prototypic oncogene Ras.
Positive_regulation (activation) of Ras associated with cancer
3) Confidence 0.11 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.30 Pain Relevance 0.14
It has been found that all carcinogenic mutations of the ras oncogene affect codons in the domain responsible for GTP binding leading to a decrease in the GTPase activity, causing permanent activation of the ras protein [73].
Positive_regulation (activation) of ras
4) Confidence 0.10 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.38 Pain Relevance 0
Tumor-specific antigens appear de novo after cancer cells acquire mutations within the coding regions of certain genes, for example the oncogene ras [29] and the tumor suppressor p53 [30], or novel fusion proteins are generated as in the case of the Bcr-Abl fusion in chronic myeloid leukemia [31].
Positive_regulation (generated) of ras associated with leukemia and cancer
5) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 1.85 Pain Relevance 0.03
Following RAS activation, BRAF is recruited to the cell membrane and then phosphorylates MEK in the cytoplasm.
Positive_regulation (activation) of RAS
6) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.64 Pain Relevance 0.38
RAS activation is the first step in the activation of the MAPK cascade.
Positive_regulation (activation) of RAS
7) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.59 Pain Relevance 0.32
Activation mutations in Ras result in the
Positive_regulation (Activation) of Ras
8) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.00 Pain Relevance 0.14
During tumorigenesis, activated RAS is usually associated with enhanced proliferation, transformation, and cell survival.
Positive_regulation (activated) of RAS
9) Confidence 0.06 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.41 Pain Relevance 0
The mechanisms by which acetylsalicylic acid and other NSAIDs, including COX-2 inhibitors, exert this effect include: inhibition of COX-2, induction of apoptosis and induction of the P21 protein that controls the development of crypt cells.
Positive_regulation (induction) of P21 protein in crypt cells associated with aspirin, cinod, cox-2 inhibitor and apoptosis
10) Confidence 0.05 Published 2003 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 14640056 Disease Relevance 0.64 Pain Relevance 0.28
Conversely, K-ras mutations occur with equal frequency in tumors with and without hyperplasia, and the epidemiologic results seem to suggest that K-ras activation is associated with malignant progression of endometrial tumors without the need for transition via hyperplasia [11].
Positive_regulation (activation) of ras associated with malignant neoplastic disease, cancer, endometrial cancer and hyperplasia
11) Confidence 0.03 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.47 Pain Relevance 0
The significant effects of the p53 rescue drug CP-31398 correlated with the increase in cellular death induced by telomere shortening-induced DNA damage signals, including increases in p53 and p21 protein levels.
Positive_regulation (increases) of p21 protein in telomere associated with death
12) Confidence 0.03 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702583 Disease Relevance 0.71 Pain Relevance 0.20
To determine whether VPA modulated the MAPK pathway upstream or downstream of Ras, the effects of VPA were investigated in L929 cells expressing constitutively active Ras (caRas).
Positive_regulation (active) of caRas in L929
13) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
GRB2

GRB2 is an adaptor protein involved in signal transduction [59] by mediating the activation of RAS in complex with epidermal growth factor receptor and son of sevenless (SOS) [60].

Positive_regulation (activation) of RAS
14) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0.06 Pain Relevance 0.03
Also, G-protein-coupled receptor activation of Src family members may result in activation of ERK1/2 via activation of Ras [17, 18] or via transactivation of the EGFR.
Positive_regulation (activation) of Ras
15) Confidence 0.01 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583213 Disease Relevance 0 Pain Relevance 0.06

General Comments

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