INT109983

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.66
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
motor neurons 2
neuronal 1
Hspb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 75 98.94 Very High Very High Very High
cytokine 22 98.36 Very High Very High Very High
Neuropeptide 5 85.60 High High
Neuronal nitric oxide synthase 2 60.00 Quite High
Spinal cord 17 39.20 Quite Low
Sciatica 4 25.00 Low Low
Inflammatory response 22 10.56 Low Low
GABA receptor 1 8.56 Low Low
ketamine 6 5.00 Very Low Very Low Very Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 11 100.00 Very High Very High Very High
INFLAMMATION 101 98.94 Very High Very High Very High
Recurrence 123 98.64 Very High Very High Very High
Death 16 98.40 Very High Very High Very High
Ulcers 288 98.14 Very High Very High Very High
Stress 22 98.12 Very High Very High Very High
Peptic Ulcer 102 98.08 Very High Very High Very High
Apoptosis 47 93.76 High High
Diabetic Retinopathy 32 82.96 Quite High
Nervous System Malformation 1 69.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The persistent upregulation of HSP27 and its colocalization with nNOS in surviving motor neurons may imply a keen competition in motor neuron survival between cytotoxic and cytoprotective systems.
Positive_regulation (upregulation) of HSP27 in motor neurons
1) Confidence 0.66 Published 2003 Journal Arch. Histol. Cytol. Section Abstract Doc Link 12703557 Disease Relevance 0.27 Pain Relevance 0
This event was followed by the induction of nNOS in the surviving large motor neurons, which showed a significant upregulation of HSP27.
Positive_regulation (upregulation) of HSP27 in motor neurons
2) Confidence 0.66 Published 2003 Journal Arch. Histol. Cytol. Section Abstract Doc Link 12703557 Disease Relevance 0.30 Pain Relevance 0.03
While the induction of HSPs seems to be important for protection against apoptosis, protease inhibition, refolding, and activity of partially denatured proteins, other reports indicate that their beneficial effect may be especially important for the later phase of regeneration, when oxidative stress caused by infiltrating inflammatory cells may oppose tissue repair [33, 34], signifying that HSP27 induction might be one of mechanisms lower recurrence of gastric ulcer after IL-1?
Positive_regulation (induction) of HSP27 associated with stress, inflammation, peptic ulcer, apoptosis and recurrence
3) Confidence 0.37 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 1.65 Pain Relevance 0.19
We could find the plausible mechanisms for resistance to ulcer recurrence in group III, which were excellent remodeling activity, enrichments of molecular chaperones like heat shock protein 27 (HSP27), significant decreases in inflammatory cytokines like COX-2, IL-2, and TNF-?
Positive_regulation (chaperones) of heat shock protein 27 associated with inflammation, shock, ulcers, recurrence and cytokine
4) Confidence 0.37 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 1.95 Pain Relevance 0.14
We could find the plausible mechanisms for resistance to ulcer recurrence in group III, which were excellent remodeling activity, enrichments of molecular chaperones like heat shock protein 27 (HSP27), significant decreases in inflammatory cytokines like COX-2, IL-2, and TNF-?
Positive_regulation (chaperones) of HSP27 associated with inflammation, shock, ulcers, recurrence and cytokine
5) Confidence 0.37 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 1.95 Pain Relevance 0.14
Eight of these genes encode neurotrophic/growth factor receptors (Lifr, Crhr1, Gfra2, Gfra1, Ntrk2, Ntrk1, Cntfr, and Adcyap1r1), and 7 encode agents that enhance neuronal survival or axonal regeneration (Hspb1, Ntf5, Tgfa, Zfp91, Artn, Tgfb1, and Mt3).
Positive_regulation (enhance) of Hspb1 in neuronal
6) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.21 Pain Relevance 0.09
Of the 15 inflammatory genes tested, 12 genes (C1-INH, CCR5, CD44, CHI3L1, HSPB1, JAK3, LGALS3, LGALS3BP, LAMA5, PEDF, STAT3, TIMP1) were reproducibly upregulated at 3 months (Figures 4 &5).
Positive_regulation (upregulated) of HSPB1 associated with inflammation
7) Confidence 0.34 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.33 Pain Relevance 0.12

General Comments

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