INT110

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2008
Negated 5
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 8.09
Pain Relevance 13.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb3) plasma membrane (Adrb3) nucleus (Adrb3)
signal transducer activity (Adrb3)
Anatomy Link Frequency
plasma 2
tail 1
colon 1
brain 1
supraoptic nucleus 1
Adrb3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 49 100.00 Very High Very High Very High
antagonist 39 100.00 Very High Very High Very High
Clonidine 25 100.00 Very High Very High Very High
qutenza 12 99.80 Very High Very High Very High
nMDA receptor 2 99.80 Very High Very High Very High
Calcium channel 2 99.80 Very High Very High Very High
anesthesia 7 99.74 Very High Very High Very High
fluoxetine 7 99.68 Very High Very High Very High
gABA 3 99.68 Very High Very High Very High
narcan 2 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 15 100.00 Very High Very High Very High
Hypotension 4 100.00 Very High Very High Very High
Autonomic Nervous System Disease 8 99.80 Very High Very High Very High
Functional Bowel Disorder 2 99.34 Very High Very High Very High
Obesity 3 99.16 Very High Very High Very High
Multiple System Atrophy 7 98.72 Very High Very High Very High
Hypertension 22 98.56 Very High Very High Very High
Cv Unclassified Under Development 7 98.36 Very High Very High Very High
Asthma 3 97.96 Very High Very High Very High
Drug Dependence 2 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results confirm previous evidence against the involvement of beta-adrenoceptor upregulation on morphine withdrawal behaviors and also permit to discard beta-adrenoceptor regulation as the neurochemical basis of the antiwithdrawal effect of yohimbine.
Regulation (regulation) of beta-adrenoceptor associated with withdrawal and morphine
1) Confidence 0.60 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077587 Disease Relevance 0.13 Pain Relevance 1.20
These findings suggest that the pressor effect of beta-adrenoceptor blocking agents during treatment with clonidine occurs at the level of beta 2-adrenoceptors in the periphery.
Regulation (effect) of beta-adrenoceptor associated with clonidine
2) Confidence 0.44 Published 1979 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 94621 Disease Relevance 0.30 Pain Relevance 0.74
The effect of selective beta-adrenoceptor agonists on isometric force recordings of spontaneous contractile activity and electrically integrated activity were determined in isolated proximal cat and rat colon strips.
Regulation (effect) of beta-adrenoceptor in colon associated with agonist
3) Confidence 0.44 Published 1985 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2869641 Disease Relevance 0 Pain Relevance 0.12
The effects of beta-adrenoreceptor blockade on oxygen consumption during cardiopulmonary bypass.
Regulation (effects) of beta-adrenoreceptor
4) Confidence 0.42 Published 1994 Journal Anesth. Analg. Section Title Doc Link 7912042 Disease Relevance 0.09 Pain Relevance 0.08
Clonidine and beta-adrenoceptor antagonists are clinically the most important of these agents, but numerous other drugs have been implicated.
Regulation (important) of beta-adrenoceptor associated with antagonist and clonidine
5) Confidence 0.42 Published 1987 Journal Med Toxicol Adverse Drug Exp Section Abstract Doc Link 3312931 Disease Relevance 0.34 Pain Relevance 0.55
Effect of beta-adrenoreceptor blockade with nadolol on the duration of local anesthesia.
Regulation (Effect) of beta-adrenoreceptor associated with anesthesia
6) Confidence 0.42 Published 1999 Journal J Am Dent Assoc Section Title Doc Link 10599182 Disease Relevance 0.28 Pain Relevance 0.56
The past 10 years have firmly established the role of beta-adrenoceptor blocking agents in the treatment of hypertension.
Regulation (role) of beta-adrenoceptor associated with hypertension
7) Confidence 0.42 Published 1976 Journal Postgrad Med J Section Abstract Doc Link 9635 Disease Relevance 0.50 Pain Relevance 0.06
The introduction of beta-adrenoceptor antagonists was a major advance in the treatment of hypertension and coronary artery disease.
Regulation (introduction) of beta-adrenoceptor in coronary artery associated with coronary artery disease, antagonist and hypertension
8) Confidence 0.42 Published 1988 Journal Am. J. Cardiol. Section Abstract Doc Link 2893532 Disease Relevance 0.20 Pain Relevance 0.05
The effects of beta-adrenoreceptor and calcium channel-blocking agents on the balance of myocardial oxygen supply and demand were studied in 15 patients (2 women and 13 men), aged 46 to 69 (mean 62) years, with variable-threshold angina.
Regulation (effects) of beta-adrenoreceptor associated with angina and calcium channel
9) Confidence 0.41 Published 1994 Journal Am. Heart J. Section Abstract Doc Link 8296698 Disease Relevance 0.17 Pain Relevance 0.22
In the present study, we adopted the rat tail suspension for 4 wk to simulate weightlessness; then the effects of simulated microgravity on beta-adrenoceptor signaling were studied.
Regulation (effects) of beta-adrenoceptor in tail
10) Confidence 0.41 Published 2008 Journal J. Appl. Physiol. Section Abstract Doc Link 18511523 Disease Relevance 0.05 Pain Relevance 0
The effect of beta-adrenoceptor antagonists on noradrenaline release in ischemia has been investigated in the present study.
Regulation (effect) of beta-adrenoceptor associated with ischemia, antagonist and noradrenaline
11) Confidence 0.40 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2314483 Disease Relevance 0.32 Pain Relevance 0.52
Antidiuretic effects of alpha- and beta-adrenoceptor agonists microinjected into the hypothalamic supraoptic nucleus in a water-loaded and ethanol-anesthetized rat.
Regulation (effects) of beta-adrenoceptor in supraoptic nucleus associated with anesthesia and agonist
12) Confidence 0.39 Published 1985 Journal Jpn. J. Pharmacol. Section Title Doc Link 2869167 Disease Relevance 0 Pain Relevance 0.36
Antidiuretic effects of alpha- and beta-adrenoceptor agonists microinjected into the hypothalamic paraventricular nucleus in a water-loaded and ethanol-anesthetized rat.
Regulation (effects) of beta-adrenoceptor in nucleus associated with anesthesia and agonist
13) Confidence 0.39 Published 1986 Journal Jpn. J. Pharmacol. Section Title Doc Link 2871211 Disease Relevance 0 Pain Relevance 0.33
Affinities for alpha- and beta-adrenoceptor subtypes of YM-09538, a new combined alpha- and beta-adrenoceptor antagonist, by radioligand binding assay.
Regulation (Affinities) of beta-adrenoceptor associated with antagonist
14) Confidence 0.38 Published 1983 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 6135396 Disease Relevance 0 Pain Relevance 0.45
The effect of chronic beta-adrenoreceptor blockade (beta-blockade) on hemodynamics and oxygen consumption (VO2) during cardiopulmonary bypass (CPB) in mild hypothermia (34 degrees C) was studied in 34 patients.
Regulation (effect) of beta-adrenoreceptor associated with hypothermia
15) Confidence 0.37 Published 1994 Journal Anesth. Analg. Section Abstract Doc Link 7912042 Disease Relevance 0.10 Pain Relevance 0.06
The effect of some beta-adrenoceptor agonists, such as clenbuterol, salbutamol, isoprenaline and formoterol on the NA turnover (estimated on the basis of NA disappearance after inhibition of its synthesis by FLA-63) in various regions of the rat brain was examined.
Spec (examined) Regulation (effect) of beta-adrenoceptor in brain associated with agonist
16) Confidence 0.32 Published 1985 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 2870484 Disease Relevance 0 Pain Relevance 0.31
The observations suggest that kappa-opioid receptor stimulation abolishes the effect of beta-adrenoceptor stimulation on arrhythmias and [Ca2+]i oscillation via a cAMP-dependent pathway.
Regulation (effect) of beta-adrenoceptor associated with kappa opioid receptor
17) Confidence 0.31 Published 1999 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 10525419 Disease Relevance 0 Pain Relevance 0.31
Fluoxetine, alone, had no affect on beta-adrenoceptor density at any time point examined.
Neg (no) Regulation (affect) of beta-adrenoceptor associated with fluoxetine
18) Confidence 0.27 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2465908 Disease Relevance 0 Pain Relevance 0.79
Finally, the influence of alpha- and beta-adrenoceptor antagonists on plasma lipids and carbohydrate metabolism is briefly reviewed.
Regulation (influence) of beta-adrenoceptor in plasma associated with antagonist
19) Confidence 0.25 Published 1988 Journal Am. Heart J. Section Abstract Doc Link 2903648 Disease Relevance 0.19 Pain Relevance 0.18
Desipramine (DMI) decreased the beta adrenoceptor population with high agonist affinity to the same degree in PCPA-treated animals as in control animals, thus explaining the reported discrepancy between beta adrenoceptor number and responsiveness of the beta adrenoceptor-coupled adenylate cyclase system.
Regulation (responsiveness) of beta adrenoceptor-coupled associated with desipramine and agonist
20) Confidence 0.24 Published 1989 Journal Neuropsychopharmacology Section Abstract Doc Link 2568116 Disease Relevance 0 Pain Relevance 0.37

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