INT110004

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.61
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Plcg1) signal transduction (Plcg1) plasma membrane (Plcg1)
lipid metabolic process (Plcg1) cytoplasm (Plcg1) signal transducer activity (Plcg1)
Anatomy Link Frequency
PAG 4
Plcg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 48 99.98 Very High Very High Very High
antinociception 38 99.56 Very High Very High Very High
opioid receptor 41 98.56 Very High Very High Very High
Central grey 11 94.72 High High
Antinociceptive 5 90.56 High High
agonist 19 81.60 Quite High
Enkephalin 3 78.40 Quite High
Nerve growth factor 1 71.44 Quite High
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 33 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, morphine also caused a robust increase in the number of phosphorylated-PLC gamma 1 (p-PLC gamma 1) expressing cells in the PAG.
Gene_expression (expressing) of PLC gamma 1 in PAG associated with urological neuroanatomy and morphine
1) Confidence 0.41 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884752 Disease Relevance 0.26 Pain Relevance 1.43
Furthermore, morphine also caused a robust increase in the number of phosphorylated-PLC gamma 1 (p-PLC gamma 1) expressing cells in the PAG.
Gene_expression (expressing) of PLC gamma 1 in PAG associated with urological neuroanatomy and morphine
2) Confidence 0.35 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884752 Disease Relevance 0.26 Pain Relevance 1.42
Treatment s.c. with morphine produced a robust increase in the number of phosphorylated-PLCgamma1 (p-PLCgamma1) expressing cells in the PAG.
Gene_expression (expressing) of PLCgamma1 in PAG associated with urological neuroanatomy and morphine
3) Confidence 0.35 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706255 Disease Relevance 0.48 Pain Relevance 1.03
Treatment s.c. with morphine produced a robust increase in the number of phosphorylated-PLCgamma1 (p-PLCgamma1) expressing cells in the PAG.
Gene_expression (expressing) of PLCgamma1 in PAG associated with urological neuroanatomy and morphine
4) Confidence 0.35 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706255 Disease Relevance 0.48 Pain Relevance 1.03
Morphine produced a marked increase in the protein level of membrane-bound PLC gamma 1, and this increase induced by morphine was significantly inhibited by intracerebroventricullar (i.c.v.) pretreatment with PI3K inhibitors at the dosage that suppressed the morphine-induced supraspinal antinociception.
Gene_expression (produced) of PLC gamma 1 associated with antinociception and morphine
5) Confidence 0.32 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884752 Disease Relevance 0.26 Pain Relevance 1.14
After s.c. treatment with morphine, the intensive PLCgamma1-IR was detected in the cell surface of the positive cells.
Gene_expression (detected) of PLCgamma1 associated with morphine
6) Confidence 0.27 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706255 Disease Relevance 0.44 Pain Relevance 0.88
Additionally, phosphorylated-phospholipase Cgamma1 (PLCgamma1-IR) was highly detected in the membrane compartment of the increased PI3Kgamma-IR-positive cells of this region.
Gene_expression (detected) of phosphorylated-phospholipase Cgamma1
7) Confidence 0.11 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.43 Pain Relevance 0.95

General Comments

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