INT110017

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 20
Disease Relevance 1.64
Pain Relevance 10.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 3
brain 2
spines 1
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 756 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Neuropathic pain 3 99.68 Very High Very High Very High
Glutamate 139 99.56 Very High Very High Very High
Neurotransmitter 78 98.62 Very High Very High Very High
Kinase C 372 98.24 Very High Very High Very High
nMDA receptor 201 97.80 Very High Very High Very High
Morphine 702 97.74 Very High Very High Very High
Pain 19 94.76 High High
tolerance 259 93.44 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 7 99.84 Very High Very High Very High
Neuropathic Pain 3 99.68 Very High Very High Very High
Pain 37 94.76 High High
INFLAMMATION 10 92.64 High High
Urological Neuroanatomy 169 72.08 Quite High
Apoptosis 9 69.84 Quite High
Death 9 58.32 Quite High
Depression 77 5.00 Very Low Very Low Very Low
Nociception 63 5.00 Very Low Very Low Very Low
Injury 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Akt induces a rapid and transient phosphorylation of nNOS Ser1417 (7) resulting in increased NO production (8), release of zinc ions from metallothioneins (9) and recruitment of PKC?
Phosphorylation (phosphorylation) of nNOS Ser1417 associated with kinase c
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.30
Considering that time 0 is the moment of morphine icv-injection, the earliest event observed was Akt activation, which was immediately followed by the activating phosphorylation of nNOS.
Phosphorylation (phosphorylation) of nNOS associated with morphine
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.06
Similar to Akt, membrane-associated nNOS had regulatory phosphorylation at Ser1417 and Ser847, but phosphorylation was almost undetectable for MOR-associated nNOS.
Phosphorylation (phosphorylation) of nNOS associated with opioid receptor
3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 0.84
The rapid and transient MOR-dependent Akt-mediated nNOS serine1417 phosphorylation followed by sustained CaMKII phosphorylation of serine847 has also been observed for NMDAR-activated PI3K-Akt [38].
Phosphorylation (phosphorylation) of nNOS associated with opioid receptor
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.49
Moreover, transient Akt-activating phosphorylation of nNOS Ser1417 [38] was followed by a robust increase in CaMKII-mediated inactivating phosphorylation of nNOS Ser847 [57].
Phosphorylation (phosphorylation) of nNOS
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.20 Pain Relevance 1.07
Membrane-associated nNOS was phosphorylated by Akt on Ser1417.
Phosphorylation (phosphorylated) of nNOS
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.79
Moreover, transient Akt-activating phosphorylation of nNOS Ser1417 [38] was followed by a robust increase in CaMKII-mediated inactivating phosphorylation of nNOS Ser847 [57].
Phosphorylation (phosphorylation) of nNOS Ser1417
7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.19 Pain Relevance 1.04
Similar to Akt, membrane-associated nNOS had regulatory phosphorylation at Ser1417 and Ser847, but phosphorylation was almost undetectable for MOR-associated nNOS.
Phosphorylation (phosphorylation) of nNOS associated with opioid receptor
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 0.88
Similar to Akt, membrane-associated nNOS had regulatory phosphorylation at Ser1417 and Ser847, but phosphorylation was almost undetectable for MOR-associated nNOS.
Phosphorylation (phosphorylation) of nNOS associated with opioid receptor
9) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.05 Pain Relevance 0.83
In addition to phosphorylation, nNOS activity or its location may be influenced by interactions with a number of proteins (Rodriguez-Crespo et al., 1998; Billecke et al., 2002; Jaffrey et al., 2002; Dreyer et al., 2004) but additional work is needed to clarify their functional significance.
Phosphorylation (phosphorylation) of nNOS
10) Confidence 0.32 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.08 Pain Relevance 0.17
Phosphorylation of nNOS in neuroblastoma cells incubated with a phosphatase inhibitor occurred on threonine-1296 resulting in an ?
Phosphorylation (Phosphorylation) of nNOS associated with neuroblastoma
11) Confidence 0.28 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.10 Pain Relevance 0.15
The presence of serine-1412-phosphorylated nNOS in a rat brain lysate (Rameau et al., 2007) indicates that the modification occurs in vivo and it may produce a stimulatory effect (as with eNOS; see below) by increasing the sensitivity of nNOS to Ca2+/calmodulin (Adak et al., 2001; Rameau et al., 2007).
Phosphorylation (phosphorylated) of nNOS in brain
12) Confidence 0.28 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.08 Pain Relevance 0.17
In the cultured neurones, phosphorylated nNOS was concentrated in dendritic spines but the phosphorylation process was slow, taking 15 min to be detectable (Rameau et al., 2004), suggesting that CaMKII is likely to be not a dynamic regulator of nNOS activity but more a longer-term gain controller.
Phosphorylation (phosphorylated) of nNOS in spines
13) Confidence 0.28 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.14
The protein kinase Akt (also known as protein kinase B) phosphorylated nNOS in cultured cortical neurones on serine-1412 (Rameau et al., 2007).
Phosphorylation (phosphorylated) of nNOS
14) Confidence 0.28 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.17
When studied in cultured hippocampal neurones, glutamate had a dual effect on nNOS phosphorylation on serine-847, increasing it at low concentrations (5 ?
Phosphorylation (phosphorylation) of nNOS associated with glutamate
15) Confidence 0.28 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.17
Both were mediated by NMDA receptors, with the phosphorylation blocked by CaMKII inhibition and dephosphorylation by concentrations of okadaic acid active on protein phosphatase 1 (Rameau et al., 2004). nNOS phosphorylated on serine-847 was found to exist in rat brain (Hayashi et al., 1999), indicating it to be a physiologically relevant modification.
Phosphorylation (phosphorylated) of nNOS in brain associated with nmda receptor
16) Confidence 0.28 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.15
We recently demonstrated that continuous production of nitric oxide (NO) by neuronal NO synthase (nNOS) following phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS) and NMDA receptor NR2B subunits is essential for neuropathic pain.
Phosphorylation (phosphorylation) of nNOS in neuronal associated with nmda receptor and neuropathic pain
17) Confidence 0.23 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.28 Pain Relevance 0.41
We recently demonstrated that continuous production of nitric oxide (NO) by neuronal NO synthase (nNOS) following phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS) and NMDA receptor NR2B subunits is essential for neuropathic pain.
Phosphorylation (phosphorylation) of neuronal NO synthase in neuronal associated with nmda receptor and neuropathic pain
18) Confidence 0.23 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.28 Pain Relevance 0.41
Immunophilin ligands, cyclosporine A and FK506 (tacrolimus), besides their immunosuppressive action, have several effects on different neural functions, such as modulation of the release of many neurotransmitters, the reduction of nitric oxide (NO) production by the inhibition of dephosphorylation of neuronal nitric oxide synthase (nNOS) and the alteration of the expression of certain genes.
Phosphorylation (dephosphorylation) of neuronal nitric oxide synthase in neuronal associated with neurotransmitter and neuronal nitric oxide synthase
19) Confidence 0.22 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706476 Disease Relevance 0 Pain Relevance 0.62
These phosphorylation and nNOS activity visualized by NADPH-diaphorase histochemistry were blocked by indomethacin, a PG synthesis inhibitor.
Phosphorylation (phosphorylation) of nNOS
20) Confidence 0.20 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.27 Pain Relevance 0.43

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