INT110019

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Context Info
Confidence 0.08
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
neuronal 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Neurotransmitter 1 98.90 Very High Very High Very High
Opioid 1 79.52 Quite High
tolerance 7 78.32 Quite High
addiction 6 77.20 Quite High
Morphine 9 75.00 Quite High
narcan 3 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunophilin ligands, cyclosporine A and FK506 (tacrolimus), besides their immunosuppressive action, have several effects on different neural functions, such as modulation of the release of many neurotransmitters, the reduction of nitric oxide (NO) production by the inhibition of dephosphorylation of neuronal nitric oxide synthase (nNOS) and the alteration of the expression of certain genes.
Negative_regulation (inhibition) of Phosphorylation (dephosphorylation) of nNOS in neuronal associated with neurotransmitter and neuronal nitric oxide synthase
1) Confidence 0.08 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706476 Disease Relevance 0 Pain Relevance 0.62

General Comments

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