INT110020

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2011
Negated 7
Speculated 3
Reported most in Body
Documents 142
Total Number 149
Disease Relevance 72.33
Pain Relevance 30.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
muscle 7
spinal cord 5
skeletal muscle 3
embryo 3
microglial cells 3
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 130 100.00 Very High Very High Very High
COX2 117 100.00 Very High Very High Very High
Kinase C 31 100.00 Very High Very High Very High
Inflammation 1987 99.98 Very High Very High Very High
Neuropathic pain 987 99.88 Very High Very High Very High
Painful diabetic neuropathy 108 99.84 Very High Very High Very High
dexamethasone 11 99.82 Very High Very High Very High
Spinal cord 537 99.68 Very High Very High Very High
rheumatoid arthritis 228 99.68 Very High Very High Very High
agonist 270 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 834 100.00 Very High Very High Very High
Adenocarcinoma 186 100.00 Very High Very High Very High
Ganglion Cysts 154 100.00 Very High Very High Very High
INFLAMMATION 2458 99.98 Very High Very High Very High
Nervous System Injury 402 99.98 Very High Very High Very High
Neuropathic Pain 1412 99.88 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 756 99.84 Very High Very High Very High
Diabetic Neuropathy 183 99.84 Very High Very High Very High
Myeloid Leukemia 64 99.84 Very High Very High Very High
Congenital Anomalies 53 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our first objective was to characterize the expression of regulatory kinase gene products upstream of p38 MAPK during preimplantation development.
Gene_expression (expression) of p38 MAPK
1) Confidence 0.77 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.09 Pain Relevance 0
is the most abundant isoform and expressed in DRG neurons (unpublished observation), p38?
Gene_expression (expressed) of p38 in neurons associated with dorsal root ganglion
2) Confidence 0.70 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.84 Pain Relevance 0.61
We have recently demonstrated a requirement for p38 MAPK signaling during preimplantation development by characterizing the reversible developmental blockade that occurs at the 8- to 16-cell stage following inhibition of MAPK14/p38?
Gene_expression (/) of MAPK14 in 16-cell stage
3) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
Relative abundance of mRNAs encoding Ccm2, Map3k3, Map2k3, Map2k6, Map2k4 and Mapk14 during mouse preimplantation development
Gene_expression (encoding) of Mapk14
4) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
[11], MAPK11/p38?
Gene_expression (/) of p38
5) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.09 Pain Relevance 0.04
[13], and MAPK13/p38?
Gene_expression (/) of p38
6) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.10 Pain Relevance 0.05
, and MAPK13/p38?)
Gene_expression (/) of p38
7) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.05 Pain Relevance 0
[12], MAPK12/p38?
Gene_expression (/) of p38
8) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.09 Pain Relevance 0.05
We have reported that all four p38 MAPK isoforms are expressed throughout mouse preimplantation development [23].
Gene_expression (expressed) of p38 MAPK
9) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.15 Pain Relevance 0.17
The discovery of a class of compounds called cytokine-suppressive anti-inflammatory drugs (CSAIDs) has allowed for the specific pharmacological inhibition of MAPK14/p38?
Gene_expression (/) of p38 associated with inflammation, cinod and cytokine
10) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.17 Pain Relevance 0.18
and MAPK11/p38?
Gene_expression (/) of p38
11) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.17 Pain Relevance 0.18
The present study was conducted to investigate whether CCM2 and upstream p38 MAPK pathway constituents are expressed during preimplantation development and to determine whether changes in CCM2 expression are associated with p38 MAPK activation following exposure of preimplantation embryos to hyperosmotic stimuli.
Gene_expression (expressed) of p38 MAPK in embryos
12) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.10 Pain Relevance 0
Effect of culture in 1800 mOsm hyperosmotic medium on blastocyst morphology and p38 MAPK activation
Gene_expression (activation) of p38 MAPK
13) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
The discovery of a class of compounds called cytokine-suppressive anti-inflammatory drugs (CSAIDs) has allowed for the specific pharmacological inhibition of MAPK14/p38?
Gene_expression (/) of MAPK14 associated with inflammation, cinod and cytokine
14) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.17 Pain Relevance 0.18
and MAPK11/p38?
Gene_expression (/) of p38
15) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
We have recently demonstrated a requirement for p38 MAPK signaling during preimplantation development by characterizing the reversible developmental blockade that occurs at the 8- to 16-cell stage following inhibition of MAPK14/p38?
Gene_expression (/) of p38 in 16-cell stage
16) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
expression via p38.
Gene_expression (expression) of p38
17) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.99 Pain Relevance 0.59
On the other hand, the amount of phosphorylated p38MAPK protein expression showed a decrease from the amount in the control group after the addition of MIP-1alpha.
Gene_expression (expression) of p38MAPK
18) Confidence 0.65 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.26 Pain Relevance 0.04
In addition, protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and chelerythrine, significantly inhibited guanfacine-induced interleukin-12 production and p38 MAPK in a concentration-dependent manner.
Gene_expression (production) of p38 MAPK associated with kinase c
19) Confidence 0.61 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.59
We used a phosphorylated p38 antibody to examine p38 activation in the rat spinal cord after spinal nerve ligation (SNL), a commonly used neuropathic pain model [34].
Gene_expression (antibody) of p38 in spinal cord associated with spinal nerve ligature, neuropathic pain and spinal cord
20) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.87 Pain Relevance 1.09

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