INT110021

Context Info Confidence 0.46 First Reported 2003 Last Reported 2011 Negated 4 Speculated 0 Reported most in Body Documents 29 Total Number 30 Disease Relevance 19.06 Pain Relevance 3.86

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14) cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)

Anatomy Link Frequency muscles 8 lungs 8 endothelial cell 4 embryo 2 spinal cord 2 Mapk14 (Mus musculus)

Pain Link Frequency Relevance Heat dexamethasone 9 99.98 Inflammatory stimuli 6 99.98 Inflammation 860 99.68 Spinal cord 28 99.40 cytokine 165 99.16 Inflammatory response 230 98.94 Kinase C 11 97.50 Inflammatory marker 8 96.36 agonist 57 93.20 Thalamus 7 87.12

Disease Link Frequency Relevance Heat Apoptosis 170 100.00 Congenital Anomalies 6 99.84 INFLAMMATION 1122 99.82 Disease 345 99.76 Stress 218 99.74 Hypoxia 39 99.70 Middle Cerebral Artery Infarction 37 99.22 Asthma 101 99.20 Diabetes Mellitus 315 99.16 Chronic Obstructive Pulmonary Disease 864 98.76

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Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation Background

Positive_regulation (increased) of Gene_expression (expression) of p38 MAPK in embryo

1) Confidence 0.46 Published 2007 Journal BMC Dev Biol Section Title Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0

Upon SOD2 overexpression, the deficits in axonal transport recovered in association with restoration of levels of phosphorylated p38 MAPK and tau protein.

Positive_regulation (overexpression) of Gene_expression (overexpression) of p38 MAPK

2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.01 Pain Relevance 0.10

TA muscles transfected with empty vector, dominant negative forms of p38?

Positive_regulation (transfected) of Gene_expression (transfected) of p38 in muscles

3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0

A unique feature of our studies is the comparison of stimulation-induced global gene expression between p38?

Positive_regulation (induced) of Gene_expression (expression) of p38

4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0

In addition, in a model of anoxia-reoxygenation-induced lung endothelial cell apoptosis, SB203580 or transfection with a p38?

Positive_regulation (transfection) of Gene_expression (transfection) of p38 in endothelial cell associated with hypoxia and apoptosis

5) Confidence 0.40 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.08 Pain Relevance 0

In addition, in a model of anoxia-reoxygenation-induced lung endothelial cell apoptosis, SB203580 or transfection with a p38?

Positive_regulation (induced) of Gene_expression (transfection) of p38 in endothelial cell associated with hypoxia and apoptosis

6) Confidence 0.40 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.10 Pain Relevance 0

In addition, protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and chelerythrine, significantly inhibited guanfacine-induced interleukin-12 production and p38 MAPK in a concentration-dependent manner.

Positive_regulation (guanfacine-induced) of Gene_expression (production) of p38 MAPK associated with kinase c

7) Confidence 0.40 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.60

Our finding that muscle-specific overexpression of a dominant negative form of p38?

Positive_regulation (overexpression) of Gene_expression (overexpression) of p38 in muscle

8) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0

For example, gene expression of MAPK8 and MAPK14, both of which are involved in the MAPK pathway, was upregulated (13.15-fold and 4.17-fold, resp.) in the berberine group.

Positive_regulation (upregulated) of Gene_expression (expression) of MAPK14

9) Confidence 0.38 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.18 Pain Relevance 0

RT2 profiler PCR array analysis showed that berberine upregulated the expression of glucose transporter 4 (GLUT4), mitogen-activated protein kinase 14 (MAPK14), MAPK8(c-jun N-terminal kinase, JNK), peroxisome proliferator-activated receptor ?

Positive_regulation (upregulated) of Gene_expression (expression) of MAPK14

10) Confidence 0.38 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952334 Disease Relevance 0.46 Pain Relevance 0.04

mRNA following motor nerve stimulation; however, TA muscles transfected with the dominant negative p38?

Positive_regulation (transfected) of Neg (negative) Gene_expression (transfected) of p38 in muscles

11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0

MKO mice and in skeletal muscle transfected with dominant negative p38?

Positive_regulation (transfected) of Neg (negative) Gene_expression (transfected) of p38 in skeletal muscle

12) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.13 Pain Relevance 0

mRNA following motor nerve stimulation; however, TA muscles transfected with the dominant negative p38?

Positive_regulation (following) of Neg (negative) Gene_expression (transfected) of p38 in muscles

13) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0

There was a non-significant trend towards increased levels of CB1/CB2 receptor expression in diabetic spinal cord specimens over time, while p-p38 MAPK expression elevated during the course of diabetes until the final time point when it declined (Figure 3).

Positive_regulation (elevated) of Gene_expression (expression) of p38 MAPK in spinal cord associated with diabetes mellitus and spinal cord

14) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 1.38 Pain Relevance 0.35

MCAO followed by 6 hour reperfusion caused increased levels of phosphorylated p38 MAPK that were significantly higher in the ischemic hemisphere of the cPLA2?

Positive_regulation (increased) of Gene_expression (levels) of p38 MAPK associated with middle cerebral artery infarction

15) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.74 Pain Relevance 0.11

Lignocaine and TTX significantly attenuated the effects of LPS on TLR-4, NF-kappaB, ERK and p38 MAPK expression, but not on JNK.

Neg (not) Positive_regulation (on) of Gene_expression (expression) of p38 MAPK

16) Confidence 0.29 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.11 Pain Relevance 0.36

We treated microglial cells with SB203580 (SB, 5 µM; an inhibitor of p38 MAPK) or PD98059 (PD, 5 µM; a selective inhibitor of p44/42) for 1 h prior to treatment with LPS (100 ng/mL) for 30 minutes, and found both inhibitors markedly suppressed the activation of LPS-induced p38 or p44/42 MAPKs (Fig. 2A, B).

Positive_regulation (induced) of Gene_expression (/) of p38 in microglial cells

17) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0

The expression of p38 mitogen-activated protein kinase (MAPK) is elevated in the peripheral lungs and alveolar macrophages in patients with mild or moderate COPD compared with smokers.90 This study also suggested an inverse correlation between the activation of p38 MAPK and the reduction in FEV1 and FEV1/FVC.90 An elevation of p38 MAPK may be responsible for an increase in phosphorylation of GR?

Positive_regulation (elevated) of Gene_expression (expression) of p38 in lungs associated with nicotine addiction and chronic obstructive pulmonary disease

18) Confidence 0.18 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.94 Pain Relevance 0.09

p38-mediated mitochondrial-dependent caspase-3 activation and apoptosis

Positive_regulation (dependent) of Gene_expression (activation) of p38 associated with apoptosis

19) Confidence 0.16 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513335 Disease Relevance 0.99 Pain Relevance 0.06

Inflammatory stimuli activate the three MAPK major pathways: extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK pathways.

Positive_regulation (activate) of Gene_expression (pathways) of p38 MAPK associated with inflammatory stimuli

20) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.03 Pain Relevance 0.26

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