INT110025

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Context Info
Confidence 0.63
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 39
Total Number 43
Disease Relevance 20.67
Pain Relevance 12.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
spinal 4
nerves 4
embryo 2
macrophages 2
spinal cord 2
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 86 100.00 Very High Very High Very High
Arthritis 26 100.00 Very High Very High Very High
agonist 72 99.98 Very High Very High Very High
Dynorphin 4 99.98 Very High Very High Very High
substance P 28 99.96 Very High Very High Very High
fluoxetine 16 99.84 Very High Very High Very High
intrathecal 36 99.78 Very High Very High Very High
long-term potentiation 135 99.56 Very High Very High Very High
antagonist 45 99.36 Very High Very High Very High
cytokine 244 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 180 100.00 Very High Very High Very High
Arthritis 25 100.00 Very High Very High Very High
Nervous System Injury 138 99.98 Very High Very High Very High
Injury 65 99.66 Very High Very High Very High
Hyperglycemia 113 99.48 Very High Very High Very High
INFLAMMATION 403 99.14 Very High Very High Very High
Albuminuria 108 98.76 Very High Very High Very High
Ganglion Cysts 40 98.56 Very High Very High Very High
Neuropathic Pain 334 98.00 Very High Very High Very High
Pressure And Volume Under Development 10 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Is this spontaneous activity required for p38 activation in spinal microglia?
Positive_regulation (required) of Positive_regulation (activation) of p38 in microglia
1) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.20 Pain Relevance 0.85
Previous reports also demonstrate that hyperglycemia-induced oxidative stress causes p38MAPK activation in peripheral neuronal cultures after 16 h of exposure to high glucose, after STZ-treated diabetic rats with 12 weeks of high glucose, and in the sural nerves of type 1 and 2 diabetic patients [11], [12].
Positive_regulation (causes) of Positive_regulation (activation) of p38MAPK in nerves associated with stress, hyperglycemia and diabetes mellitus
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.70 Pain Relevance 0.06
CONCLUSIONS: The data show that delta2- but not delta1-opioid agonists suppress LPS-induced p38 MAPK activation and expression of TNFalpha and MIP-2.


Positive_regulation (induced) of Positive_regulation (activation) of p38
3) Confidence 0.55 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0
Down-regulation of OSM by RNA interference demonstrated that MAP3K3 and OSM were required for p38 MAPK activation in response to sorbitol-induced hypertonicity [26].
Positive_regulation (required) of Positive_regulation (activation) of p38 MAPK
4) Confidence 0.50 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.14 Pain Relevance 0.05
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Positive_regulation (increased) of Positive_regulation (levels) of p38 associated with fluoxetine
5) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.25 Pain Relevance 0.84
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Positive_regulation (increased) of Positive_regulation (levels) of p38 associated with fluoxetine
6) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.25 Pain Relevance 0.84
One of the most exciting outcomes from our study is the differential activation of p38 MAPK that occurred in response to the solute compound used to increase the osmolarity of embryo culture media.
Positive_regulation (occurred) of Positive_regulation (activation) of p38 MAPK in embryo
7) Confidence 0.46 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.23 Pain Relevance 0
Recently, a novel scaffolding protein called Osmosensing Scaffold for MEKK3 (OSM) was linked to p38 MAPK activation in response to sorbitol-induced hypertonicity.
Positive_regulation (linked) of Positive_regulation (activation) of p38 MAPK
8) Confidence 0.46 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.09 Pain Relevance 0
In this regard it is also possible that 460 mOsm represents a near-maximal stimulus of p38 MAPK activation and thus levels beyond this would not result in any further increase in p38 MAPK activity.
Neg (not) Positive_regulation (result) of Positive_regulation (increase) of p38 MAPK
9) Confidence 0.46 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
PGE2 release evoked by intrathecal dynorphin requires spinal p38 activation [64]. p38 activation also causes a rapid release of IL-1?
Positive_regulation (causes) of Positive_regulation (activation) of p38 in spinal associated with dynorphin and intrathecal
10) Confidence 0.45 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.44 Pain Relevance 0.50
There are two potential signaling mechanisms that may underlie this effect: 1) NGF may directly induce Trk A-dependent p38 phosphorylation, or 2) NGF could indirectly activate interleukin 1-beta-dependent p38 activation to promote SP expression [36].
Positive_regulation (promote) of Positive_regulation (activation) of p38 associated with nerve growth factor, trk a and substance p
11) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.66 Pain Relevance 1.14
and Vegf transcriptional activation support the importance of p38?
Positive_regulation (support) of Positive_regulation (importance) of p38
12) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.09 Pain Relevance 0
PGE2 release evoked by intrathecal dynorphin requires spinal p38 activation [64]. p38 activation also causes a rapid release of IL-1?
Positive_regulation (requires) of Positive_regulation (activation) of p38 in spinal associated with dynorphin and intrathecal
13) Confidence 0.42 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.34 Pain Relevance 0.48
It is worthy to investigate whether p38 is required for this upregulation. p38 activation after intrathecal IL-1?
Positive_regulation (required) of Positive_regulation (activation) of p38 associated with intrathecal
14) Confidence 0.42 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.72 Pain Relevance 0.80
Our data also depicts hyperglycemia-induced oxidative stress induces activation of p38 MAPK within 1-week of STZ treatment of mice.
Positive_regulation (induces) of Positive_regulation (activation) of p38 MAPK associated with stress and hyperglycemia
15) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.85 Pain Relevance 0.07
B activation, our in vitro data are consistent with a role for activation of the p38MAPK-HSP25 pathway in the observed trend favoring maintenance of stress fibers in curcumin-treated podocytes during high glucose exposure.
Positive_regulation (role) of Positive_regulation (activation) of p38MAPK in podocytes associated with stress
16) Confidence 0.40 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.04 Pain Relevance 0
Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists.
Positive_regulation (Stimulation) of Positive_regulation (activation) of p38 in macrophages associated with agonist
17) Confidence 0.40 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.47
Deltorphin-Dvariant did not alter activation of the transcription factors NF-kappaB or AP-1, but greatly reduced activation of p38 MAPK.
Positive_regulation (activation) of Positive_regulation (activation) of p38
18) Confidence 0.39 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0
Together, these data suggest that Cd induces COX-2 expression through the activation of p38 MAPK, an oxidative stress-sensitive cellular signaling molecule, and induction of COX-2 is associated with ICAM-1 expression in brain endothelial cells following Cd exposure.
Positive_regulation (induces) of Positive_regulation (activation) of p38 in brain associated with stress
19) Confidence 0.39 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.36 Pain Relevance 0.10
M exposure further increased p38MAPK activation by a similar degree.
Positive_regulation (increased) of Positive_regulation (activation) of p38MAPK
20) Confidence 0.37 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0

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