INT110026

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.56
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
macrophages 1
Heart 1
Adrb1 (Mus musculus)
Adrb1 - S49G (1)
Pain Link Frequency Relevance Heat
antagonist 17 100.00 Very High Very High Very High
agonist 15 100.00 Very High Very High Very High
gABA 8 100.00 Very High Very High Very High
Kinase C 3 98.64 Very High Very High Very High
GABAergic 1 96.32 Very High Very High Very High
beta blocker 2 90.48 High High
Clonidine 3 86.44 High High
addiction 1 85.44 High High
Substantia nigra 2 75.00 Quite High
noradrenaline 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 48 99.54 Very High Very High Very High
Coronary Artery Disease 80 93.20 High High
Death 12 66.72 Quite High
Stroke 8 66.44 Quite High
Cv General 3 Under Development 3 58.96 Quite High
Arrhythmia Under Development 1 56.88 Quite High
Cv Unclassified Under Development 20 50.00 Quite Low
Syndrome 4 50.00 Quite Low
Heart Rate Under Development 8 45.52 Quite Low
Angina 6 43.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADRB1 and ADRB2), haplotypes were inferred using PHASE version 2.1 [15], coded based on the number of copies (0, 1, or 2), and individually entered into the regression with 0 copies as the referent category.
Localization (entered) of ADRB1
1) Confidence 0.72 Published 2008 Journal J Transl Med Section Body Doc Link PMC2329599 Disease Relevance 0.34 Pain Relevance 0
The 2001 American Heart Association and American College of Cardiology (AHA/ACC) guidelines for secondary prevention of myocardial infarction (MI) recommend initiating beta-adrenoceptor blockade in all post-MI patients and continuing therapy indefinitely.
Localization (blockade) of beta-adrenoceptor in Heart associated with myocardial infarction
2) Confidence 0.72 Published 2005 Journal Drugs Section Abstract Doc Link 15819591 Disease Relevance 0.83 Pain Relevance 0.28
1-adrenergic receptor (ADRB1; Ser49Gly and Arg389Gly), ?
Localization (receptor) of ADRB1 (S49G)
3) Confidence 0.63 Published 2008 Journal J Transl Med Section Body Doc Link PMC2329599 Disease Relevance 0.39 Pain Relevance 0
These findings show that alpha(2)-adrenoceptor agonists induce interleukin-12 production in mouse macrophages via a PKC/p38 MAPK signaling pathway and suggest that the effect of alpha(2)-adrenoceptor agonists on interleukin-12 secretion may be a new and novel means of augmenting cell-mediated immune responses.
Localization (secretion) of adrenoceptor in macrophages associated with kinase c and agonist
4) Confidence 0.07 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.53
The enhancing effect of both the alpha2 adrenoceptor agonist and antagonist on GABA release, while appearing paradoxical, can be rationalised by actions at distinct subsets of alpha2 adrenoceptors, using a simple model where alpha2A adrenoceptors are localized on the terminals of noradrenergic afferents impinging upon alpha2C adrenoceptor-containing GABAergic striato-nigral neurones.
Localization (localized) of adrenoceptor associated with gaba, gabaergic, antagonist and agonist
5) Confidence 0.00 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16356632 Disease Relevance 0 Pain Relevance 0.90

General Comments

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