INT110028

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.48
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 2
duodenum 1
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 78 100.00 Very High Very High Very High
Inflammatory response 6 100.00 Very High Very High Very High
Clonidine 2 98.92 Very High Very High Very High
agonist 19 98.56 Very High Very High Very High
Inflammation 139 91.04 High High
rheumatoid arthritis 80 90.52 High High
psoriasis 55 75.92 Quite High
antagonist 4 64.48 Quite High
Arthritis 22 49.04 Quite Low
Kinase C 6 48.16 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 142 100.00 Very High Very High Very High
Psoriasis 68 97.20 Very High Very High Very High
Rheumatoid Arthritis 81 90.52 High High
Mycobacterial Infection 116 66.88 Quite High
Infection 72 65.84 Quite High
Weight Gain 4 64.12 Quite High
Targeted Disruption 4 63.04 Quite High
Body Weight 8 58.08 Quite High
Arthritis 13 49.04 Quite Low
Disease 67 34.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Transcription (expression) of interleukin-12 in macrophages associated with agonist and clonidine
1) Confidence 0.49 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.45
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Transcription (expression) of interleukin-12 in macrophages associated with agonist and clonidine
2) Confidence 0.49 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.45
Of the 17 subjects who received the IL-12/23 monoclonal antibody, 13 (76%) achieved PASI 75, compared with no placebo subjects. mRNA expression of IL-12, IL-23, IL-8, IL-18, and IFN-?
Neg (no) Transcription (expression) of IL-12
3) Confidence 0.31 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.30 Pain Relevance 0.10
was measured in the same manner as described for IL-6 and IL-12.
Transcription (described) of IL-12
4) Confidence 0.16 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3004002 Disease Relevance 0 Pain Relevance 0
Among the treatment group, luminal IL-12 concentrations were the lowest in the duodenum, 35.79 ± 16.13?
Transcription (concentrations) of IL-12 in duodenum
5) Confidence 0.16 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3004002 Disease Relevance 0.20 Pain Relevance 0.04
In particular, while the lack of methoxy- and keto- groups may have been responsible for the loss of ability to repress the activation of IL-12 transcription, it is also possible that the novel appearance of epoxy mycolates that we observed in the ?
Transcription (transcription) of IL-12
6) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.13 Pain Relevance 0
In DC, the classical pathway drives transcription of prosurvival and pro-inflammatory response genes, including cytokines such as IL-6, TNF and IL-12.
Transcription (transcription) of IL-12 associated with inflammatory response and cytokine
7) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.85 Pain Relevance 0.48

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