INT110040

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Context Info
Confidence 0.18
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.91
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
heart 3
ventricular myocardium 1
Nppb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 97.72 Very High Very High Very High
Angina 37 77.84 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
chest pain 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
antiarrhythmic agent 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 4 100.00 Very High Very High Very High
Natriuresis 31 99.80 Very High Very High Very High
Mitral Valve Insufficiency 235 99.78 Very High Very High Very High
Coronary Heart Disease 8 99.40 Very High Very High Very High
Myocardial Infarction 195 99.28 Very High Very High Very High
Death 54 99.28 Very High Very High Very High
Heart Disease 1 98.28 Very High Very High Very High
Acute Coronary Syndrome 99 98.20 Very High Very High Very High
INFLAMMATION 14 97.72 Very High Very High Very High
Obesity 7 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association between dichotomised BNP, LVEF and MR and baseline demographic characteristics and clinical risk factors was assessed by the Fisher exact test for proportions and the Mann–Whitney U test for continuous/ordered variables.
BNP Binding (association) of associated with mitral valve insufficiency
1) Confidence 0.18 Published 2010 Journal Heart Section Body Doc Link PMC2976074 Disease Relevance 0.78 Pain Relevance 0
The B-type natriuretic peptides BNP and NT-proBNP are associated with the degree of LV dysfunction following ACS, but still provide prognostic information independently of LVEF3 4 23 and the Thrombolysis In MI (TIMI) risk score.24 In the present study we used BNP, which has been found to be as accurate as NT-proBNP for identifying CHF.25 The volume overload and stretch of the atrial and ventricular myocardium associated with MR are potent stimuli for natriuretic peptide release, suggesting that in some patients the prognostic information obtained from BNP is partly derived from its reflection of MR grade.
BNP Binding (associated) of in ventricular myocardium associated with natriuresis, heart rate under development, acute coronary syndrome, mitral valve insufficiency and myocardial infarction
2) Confidence 0.18 Published 2010 Journal Heart Section Body Doc Link PMC2976074 Disease Relevance 2.03 Pain Relevance 0
Furthermore, when MR, LVEF and BNP were forced into the same model together with clinical variables (multivariate model 3), all three factors remained significantly associated with long-term mortality (HR for MR 1.53 (95% CI 1.06 to 2.19), p=0.02; HR for LVEF 1.94 (95% CI 1.38 to 2.73), p=0.0001; and HR for BNP 1.45 (95% CI 1.06 to 1.99), p=0.02, table 2).
BNP Binding (associated) of associated with mitral valve insufficiency
3) Confidence 0.18 Published 2010 Journal Heart Section Body Doc Link PMC2976074 Disease Relevance 1.44 Pain Relevance 0.06
Factors most strongly associated with BNP measurement included signs of heart failure on presentation, older age, previous heart failure, faster presenting heart rate, and higher body mass index.
BNP Binding (associated) of in heart associated with obesity and myocardial infarction
4) Confidence 0.17 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 18082516 Disease Relevance 0.84 Pain Relevance 0.08
However, the association between anemia and high NT-proBNP in acute myocardits is unknown.
NT-proBNP Binding (association) of associated with anaemia
5) Confidence 0.15 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3004486 Disease Relevance 1.18 Pain Relevance 0.05
Of note, the association between TRAIL and CK, CK-MB and BNP was significant, as evaluated after multivariate regression adjusted for demographic and clinical parameters (Tables 2–4).
BNP Binding (association) of
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637972 Disease Relevance 0.86 Pain Relevance 0
The association between BNP and mortality at six months (adjusted odds ratio [OR] 3.3; 95% confidence interval [CI] 1.7 to 6.3) was independent of important clinical predictors, including cTnI and congestive heart failure (CHF).
BNP Binding (association) of in heart
7) Confidence 0.06 Published 2003 Journal J. Am. Coll. Cardiol. Section Body Doc Link 12706919 Disease Relevance 0.08 Pain Relevance 0
Primary end points: PR3–SERPIN A1 and NT-proBNP as predictors of death or heart failure
NT-proBNP Binding (points) of in heart associated with myocardial infarction and death
8) Confidence 0.05 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 1.12 Pain Relevance 0
Secondary end points: PR3–SERPIN A1 and NT-proBNP as predictors of myocardial infarction
NT-proBNP Binding (points) of associated with myocardial infarction
9) Confidence 0.05 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 0.60 Pain Relevance 0

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