INT11009

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Context Info
Confidence 0.82
First Reported 1992
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 458
Total Number 463
Disease Relevance 111.34
Pain Relevance 221.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
spinal cord 44
neurons 42
hippocampus 19
dorsal horn 16
spinal 11
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 1052 100.00 Very High Very High Very High
Dopamine 922 100.00 Very High Very High Very High
Hippocampus 878 100.00 Very High Very High Very High
Glutamate receptor 371 100.00 Very High Very High Very High
adenocard 185 100.00 Very High Very High Very High
Fibrositis 27 100.00 Very High Very High Very High
Spinal cord 1374 99.98 Very High Very High Very High
addiction 484 99.92 Very High Very High Very High
withdrawal 320 99.92 Very High Very High Very High
Hyperalgesia 140 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 240 99.90 Very High Very High Very High
Ganglion Cysts 903 99.84 Very High Very High Very High
Diabetes Mellitus 363 99.84 Very High Very High Very High
Multiple Sclerosis 110 99.84 Very High Very High Very High
INFLAMMATION 288 99.82 Very High Very High Very High
Nociception 1271 99.80 Very High Very High Very High
Drug Dependence 66 99.72 Very High Very High Very High
Stress 1410 99.68 Very High Very High Very High
Neuropathic Pain 251 99.42 Very High Very High Very High
Repression 18 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological activation of the cAMP-CREB signaling with rolipram 24 hours before hypoxia protected rat pups at behavioral and pathological levels by sustained increased CREB phosphorylation.
Phosphorylation (phosphorylation) of CREB associated with hypoxia
1) Confidence 0.82 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15470752 Disease Relevance 0.43 Pain Relevance 0.07
The extent of reduction of total CREB and phosphorylated CREB containing cells in the dorsal horn ipsilateral to injury was greater than in the contralateral dorsal horn.
Phosphorylation (phosphorylated) of CREB in dorsal horn associated with injury and dorsal horn
2) Confidence 0.82 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.69 Pain Relevance 0.96
The aim of this study is to determine whether increased phosphorylation of CREB in the dorsal horn contributes to the pathogenesis of neuropathic pain.
Phosphorylation (phosphorylation) of CREB in dorsal horn associated with neuropathic pain and dorsal horn
3) Confidence 0.82 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.76 Pain Relevance 0.91
Partial nerve injury elicited neuropathic pain is accompanied by increased phosphorylation of CREB in the ipsilateral spinal cord dorsal horn (Ma and Quirion, Pain 93 (2001) 295; Miletic et al., Pain 99 (2002) 493).
Phosphorylation (phosphorylation) of CREB in spinal cord dorsal horn associated with pain, nervous system injury, dorsal horn, neuropathic pain and spinal cord
4) Confidence 0.82 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.71 Pain Relevance 0.83
Total CREB and phosphorylated CREB in both ipsilateral and contralateral dorsal horn neurons were dramatically reduced in antisense ODN injected PSNL rats 1 week after injection.
Phosphorylation (phosphorylated) of CREB in neurons associated with dorsal horn neuron
5) Confidence 0.82 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.73 Pain Relevance 0.98
These data suggest that phosphorylation of CREB is an important contributing event in the central plasticity of nerve injury and in the pathogenesis of neuropathic pain.
Phosphorylation (phosphorylation) of CREB in nerve associated with nervous system injury and neuropathic pain
6) Confidence 0.82 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.84 Pain Relevance 0.92
CREB phosphorylation was very rapid and reached peak levels within 10 min of formalin treatment, whereas few pCREB-positive neurons were seen in unstimulated spinal cord.
Phosphorylation (phosphorylation) of CREB in neurons associated with spinal cord
7) Confidence 0.82 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.63 Pain Relevance 0.62
After a unilateral injection of formalin into the hindpaw, a strong and bilateral phosphorylation of CREB Ser133 was induced, as assessed by both immunohistochemistry and Western blot.
Phosphorylation (phosphorylation) of CREB
8) Confidence 0.82 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.64 Pain Relevance 0.48
In the unstimulated state, unphosphorylated CREB was observed in most nuclei of spinal neurons except for motor neurons, where only a small portion of neurons were stained.
Phosphorylation (unphosphorylated) of CREB in motor neurons
9) Confidence 0.82 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.53 Pain Relevance 0.37
Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction.
Phosphorylation (Phosphorylation) of CREB in spinal cord associated with hyperalgesia and spinal cord
10) Confidence 0.82 Published 1997 Journal J. Neurosci. Section Title Doc Link 9030636 Disease Relevance 0.64 Pain Relevance 0.48
Furthermore, our results indicate that CREB phosphorylation may be necessary but not sufficient for c-fos induction.
Phosphorylation (phosphorylation) of CREB
11) Confidence 0.82 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.34 Pain Relevance 0.69
Both formalin-evoked CREB phosphorylation and c-Fos expression in the spinal cord were suppressed by pretreatment with the NMDA receptor antagonist MK-801 (3.5 mg/kg, i.p.) or halothane anesthesia.
Phosphorylation (phosphorylation) of CREB in spinal cord associated with anesthesia, nmda receptor antagonist, halothane and spinal cord
12) Confidence 0.82 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.56 Pain Relevance 0.80
In contrast to CREB phosphorylation, the induction of c-Fos expression reached peak levels 2 hr after formalin treatment and c-Fos induction was mainly ipsilateral.
Phosphorylation (phosphorylation) of CREB
13) Confidence 0.82 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.61 Pain Relevance 0.76
We investigated the involvement of nitric oxide (NO) in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein (CREB) in the spinal cord of rats during central sensitization after intradermal capsaicin injection.
Phosphorylation (phosphorylation) of cyclic adenosine monophosphate-responsive element-binding protein in spinal cord associated with adenocard, qutenza, central sensitization and spinal cord
14) Confidence 0.82 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.69
We investigated the involvement of nitric oxide (NO) in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein (CREB) in the spinal cord of rats during central sensitization after intradermal capsaicin injection.
Phosphorylation (phosphorylation) of CREB in spinal cord associated with adenocard, qutenza, central sensitization and spinal cord
15) Confidence 0.82 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.69
CREB phosphorylation, not the level of CREB, was induced within 20 minutes by microdialysis administration of SIN-1, an NO donor.
Phosphorylation (phosphorylation) of CREB
16) Confidence 0.82 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.83
These results indicate that CREB phosphorylation in the spinal cord results from both endogenous and exogenous NO release and that p-CREB may play a role in central sensitization or in longer-term changes in gene expression induced by strong peripheral noxious stimulation.
Phosphorylation (phosphorylation) of CREB in spinal cord associated with central sensitization and spinal cord
17) Confidence 0.82 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.80
CREB phosphorylation, not the level of CREB, was induced within 20 minutes by microdialysis administration of SIN-1, an NO donor.
Phosphorylation (phosphorylation) of CREB
18) Confidence 0.82 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.83
This study examined the role of the cAMP pathway in a model of chronic muscle pain by assessing associated behavioral changes and phosphorylation of CREB.
Phosphorylation (phosphorylation) of CREB in muscle associated with pain and myalgia
19) Confidence 0.82 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12843242 Disease Relevance 0.50 Pain Relevance 0.45
Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections.
Phosphorylation (Phosphorylation) of CREB associated with hyperalgesia and fibrositis
20) Confidence 0.82 Published 2003 Journal J. Neurosci. Section Title Doc Link 12843242 Disease Relevance 0.50 Pain Relevance 0.59

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