INT110099

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.30
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce) mitochondrion (Prkce) endoplasmic reticulum (Prkce)
plasma membrane (Prkce) nucleus (Prkce) enzyme binding (Prkce)
Anatomy Link Frequency
neurons 4
Prkce (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 100.00 Very High Very High Very High
qutenza 1 94.96 High High
nociceptor 3 94.24 High High
Serotonin 1 92.32 High High
bradykinin 1 91.88 High High
Hyperalgesia 4 88.88 High High
IPN 3 79.92 Quite High
Pain 10 73.56 Quite High
Neurotransmitter 1 72.92 Quite High
Inflammation 4 71.24 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 88.88 High High
Nociception 5 85.76 High High
Inflammatory Pain 3 79.92 Quite High
Cancer 1 77.68 Quite High
Alcohol Addiction 1 77.20 Quite High
Diabetes Mellitus 1 76.72 Quite High
Neuropathic Pain 1 76.32 Quite High
Pain 1 73.56 Quite High
INFLAMMATION 1 71.24 Quite High
Ganglion Cysts 12 54.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Positive_regulation (stimulated) of Localization (translocation) of PKCepsilon
1) Confidence 0.68 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
Concomitantly, PMA-induced translocation of PKCepsilon was markedly perturbed in Nox1(-/Y) or Nox1(+/Y) DRG neurons treated with ROS-scavenging agents.
Positive_regulation (induced) of Localization (translocation) of PKCepsilon in neurons
2) Confidence 0.62 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18799680 Disease Relevance 0.54 Pain Relevance 0.74
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Positive_regulation (stimulated) of Localization (translocation) of PKCepsilon
3) Confidence 0.49 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Positive_regulation (stimulated) of Localization (translocation) of PKCepsilon
4) Confidence 0.49 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Positive_regulation (increased) of Localization (translocation) of PKCepsilon
5) Confidence 0.49 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
PKC-epsilon-LI in ICC-DMP and translocation of PKC epsilon-LI in neurons were blocked by tetrodotoxin or atropine, suggesting that these responses were due to activation of muscarinic receptors.
Positive_regulation (activation) of Localization (translocation) of PKC-epsilon in neurons associated with tetrodotoxin
6) Confidence 0.46 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.14
Epac, in turn, was upstream of phospholipase C (PLC) and PLD, both of which were necessary for translocation and activation of PKCepsilon.
Positive_regulation (activation) of Localization (translocation) of PKCepsilon
7) Confidence 0.14 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15987941 Disease Relevance 0.55 Pain Relevance 0.37

General Comments

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