INT11010

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1992
Last Reported 2010
Negated 8
Speculated 9
Reported most in Abstract
Documents 52
Total Number 62
Disease Relevance 7.26
Pain Relevance 29.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
neurons 18
spinal cord 8
NG108-15 4
nucleus 4
hippocampus 4
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 607 100.00 Very High Very High Very High
Kinase C 202 100.00 Very High Very High Very High
Morphine 124 100.00 Very High Very High Very High
narcan 79 100.00 Very High Very High Very High
withdrawal 29 100.00 Very High Very High Very High
adenocard 16 100.00 Very High Very High Very High
Analgesic 14 100.00 Very High Very High Very High
monoamine 13 100.00 Very High Very High Very High
spinal dorsal horn 11 100.00 Very High Very High Very High
Opioid 60 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 153 100.00 Very High Very High Very High
Ganglion Cysts 11 99.46 Very High Very High Very High
Nociception 234 98.92 Very High Very High Very High
Cluster Headache 1 97.94 Very High Very High Very High
INFLAMMATION 26 97.66 Very High Very High Very High
Drug Dependence 15 97.48 Very High Very High Very High
Apoptosis 24 93.92 High High
Urological Neuroanatomy 7 93.60 High High
Hyperalgesia 17 92.96 High High
Injury 20 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: The effects of the three OMF stereoisomers and morphine (Mor) on cAMP accumulation and CREB phosphorylation were monitored by radioimmunoassay and Western blot analysis, respectively.
Regulation (effects) of Phosphorylation (phosphorylation) of CREB
1) Confidence 0.62 Published 2003 Journal Acta Pharmacol. Sin. Section Body Doc Link 14653953 Disease Relevance 0 Pain Relevance 0
Effects of ohmefentanyl stereoisomers on phosphorylation of cAMP- response element binding protein in cultured rat hippocampal neurons.
Regulation (Effects) of Phosphorylation (phosphorylation) of cAMP- response element binding protein in neurons associated with analgesic
2) Confidence 0.62 Published 2003 Journal Acta Pharmacol. Sin. Section Title Doc Link 14653953 Disease Relevance 0 Pain Relevance 0.15
F9203, which could not induce dependence, had no effect on CREB phosphorylation in hippocampal neurons.
Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of CREB in neurons
3) Confidence 0.62 Published 2003 Journal Acta Pharmacol. Sin. Section Body Doc Link 14653953 Disease Relevance 0 Pain Relevance 0
Hormonal regulation of CREB phosphorylation in the anteroventral periventricular nucleus.
Regulation (regulation) of Phosphorylation (phosphorylation) of CREB in periventricular nucleus associated with enkephalin
4) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Title Doc Link 8622133 Disease Relevance 0 Pain Relevance 0.31
To determine if morphine withdrawal leads to increased CREB phosphorylation in striatal tissues, we examined the effects of naloxone-precipitated morphine withdrawal on CREB phosphorylation in primary cultures of rat striatal neurons.
Spec (examined) Regulation (effects) of Phosphorylation (phosphorylation) of CREB in neurons associated with narcan, withdrawal and morphine
5) Confidence 0.62 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.09 Pain Relevance 1.39
The present study was designed to investigate the role of calcium/camodulin protein dependent protein kinase II (CaM kinase II) in the regulation of phosphorylation of CREB after capsaicin injection.
Regulation (regulation) of Phosphorylation (phosphorylation) of CREB associated with qutenza
6) Confidence 0.61 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631885 Disease Relevance 0 Pain Relevance 0.54
Following electrical intracochlear stimulation with a cochlear implant under urethane anesthesia, we observed changes in the phosphorylation state of the cAMP response element binding protein (CREB) and the expression of the immediate-early genes c-fos and egr-1, molecules known to act as transcription factors, in a tonotopically precise pattern in central auditory neurons.
Regulation (changes) of Phosphorylation (phosphorylation) of cAMP response element binding protein in neurons associated with anesthesia
7) Confidence 0.61 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12009775 Disease Relevance 0 Pain Relevance 0.16
In the current study we used immunoblotting and immunohistochemistry to investigate changes in CREB phosphorylation in the NTS and kinases that may mediate the morphine withdrawal-triggered activation of CREB and hypothalamo-pituitary-adrenocortical (HPA) axis (another stress system circuit) response after naloxone-induced morphine withdrawal.
Spec (investigate) Regulation (changes) of Phosphorylation (phosphorylation) of CREB in pituitary associated with stress, narcan, withdrawal and morphine
8) Confidence 0.61 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.18 Pain Relevance 0.82
To understand better the mechanism by which opiates produce these intracellular adaptations, we studied morphine regulation of the state of phosphorylation of cyclic AMP response element-binding protein (CREB), a transcription factor that mediates some of the effects of the cyclic AMP system on gene expression.
Regulation (regulation) of Phosphorylation (phosphorylation) of CREB associated with opiate and morphine
9) Confidence 0.61 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1531356 Disease Relevance 0 Pain Relevance 1.00
Such regulation of CREB phosphorylation could be part of the molecular pathway by which opiates produce changes in gene expression that lead to addiction.
Regulation (regulation) of Phosphorylation (phosphorylation) of CREB associated with addiction and opiate
10) Confidence 0.61 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1531356 Disease Relevance 0 Pain Relevance 1.08
However, ACSF treatment did not affect the increased phosphorylation of CREB protein in response to capsaicin injection (2.91 ± 0.3 vs. 1.31 ± 0.31, p < 0.05).
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of CREB associated with qutenza
11) Confidence 0.60 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0 Pain Relevance 0.49
For example, it was reported that an increased CREB phosphorylation of the Serine-133 residue is responsible for the induction of long-term potentiation (LTP) in CA1 in the hippocampus.
Regulation (responsible) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus and long-term potentiation
12) Confidence 0.60 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.07 Pain Relevance 0.32
In addition, the effect of morphine on the phosphorylation of the transcription factors, cyclic AMP responsive element-binding protein (CREB) was investigated.
Regulation (effect) of Phosphorylation (phosphorylation) of CREB associated with morphine
13) Confidence 0.60 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16095816 Disease Relevance 0 Pain Relevance 0.65
However, despite the additional detection of 5-hydroxytryptamine (5-HT)(1B) receptors on these cells, the clinically effective antimigraine 5-HT(1B/1D) agonist sumatriptan did not inhibit forskolin-stimulated CGRP release nor did it show any effect on the concomitant CREB phosphorylation.
Regulation (effect) of Phosphorylation (phosphorylation) of CREB associated with cluster headache, sumatriptan, agonist and calcitonin gene-related peptide
14) Confidence 0.60 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11353815 Disease Relevance 0.10 Pain Relevance 0.99
Since multiple cAMP response element (CRE) sequences are present on the prodynorphin gene promoter, the aim of our study was to investigate the effects of cocaine and monoaminergic uptake inhibitors on CREB and DARPP-32 phosphorylation and moreover the possible correlation with the changes already observed on prodynorphin gene expression.
Spec (investigate) Regulation (effects) of Phosphorylation (phosphorylation) of CREB associated with monoamine and cocaine
15) Confidence 0.60 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.57
In contrast, in PG neurons estradiol did not affect CREB phosphorylation, highlighting a difference in E2 responses in different populations of peripheral neurons.
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of CREB in neurons associated with ganglion cysts
16) Confidence 0.59 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541884 Disease Relevance 0.80 Pain Relevance 0.39
Thus we propose the importance of dopamine receptors in modulating CREB phosphorylation and activation.
Regulation (modulating) of Phosphorylation (phosphorylation) of CREB associated with dopamine receptor
17) Confidence 0.57 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.57 Pain Relevance 0.42
Similarly, co-administration of citalopram synergistically potentiated the enhancing effect of RS 67333 on CREB protein phosphorylation within the hippocampus.
Regulation (effect) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus
18) Confidence 0.56 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.59
The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the spinal cord after intradermal injection of capsaicin.
Regulation (role) of Phosphorylation (phosphorylation) of cyclic adenosine monophosphate-responsive element-binding protein in spinal cord associated with adenocard, qutenza and spinal cord
19) Confidence 0.54 Published 2002 Journal J Pain Section Title Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.81
Following electrical intracochlear stimulation with a cochlear implant under urethane anesthesia, we observed changes in the phosphorylation state of the cAMP response element binding protein (CREB) and the expression of the immediate-early genes c-fos and egr-1, molecules known to act as transcription factors, in a tonotopically precise pattern in central auditory neurons.
Regulation (changes) of Phosphorylation (phosphorylation) of CREB in neurons associated with anesthesia
20) Confidence 0.45 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12009775 Disease Relevance 0 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox