INT110100

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.68
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce) mitochondrion (Prkce) endoplasmic reticulum (Prkce)
plasma membrane (Prkce) nucleus (Prkce) enzyme binding (Prkce)
Anatomy Link Frequency
neurons 2
Prkce (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.84 Very High Very High Very High
nMDA receptor 8 99.58 Very High Very High Very High
Morphine 15 98.92 Very High Very High Very High
Kinase C 23 98.24 Very High Very High Very High
opiate 2 96.40 Very High Very High Very High
Pain 7 94.96 High High
intrathecal 3 88.32 High High
withdrawal 1 84.00 Quite High
agonist 2 81.24 Quite High
antagonist 3 78.76 Quite High
Disease Link Frequency Relevance Heat
Pain 5 94.96 High High
Reperfusion Injury 1 89.92 High High
Diabetes Mellitus 1 87.84 High High
Nociception 1 59.44 Quite High
Injury 2 54.76 Quite High
Coronary Artery Disease 1 52.16 Quite High
Targeted Disruption 1 35.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the PRE-induced increase in the number of spinal pNR1-ir neurons was only blocked by inhibitors of the PKCalpha and PKCepsilon isoforms, but not the PKCzeta isoform.
Negative_regulation (inhibitors) of PKCepsilon in neurons
1) Confidence 0.57 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.31 Pain Relevance 0.88
Here, we show that mice lacking PKCepsilon have increased sensitivity to the rewarding effects of morphine, revealed as the expression of place preference and intravenous self-administration at very low doses of morphine that do not evoke place preference or self-administration in wild-type mice.
Negative_regulation (lacking) of PKCepsilon associated with morphine
2) Confidence 0.43 Published 2007 Journal Genes Brain Behav. Section Abstract Doc Link 16899053 Disease Relevance 0 Pain Relevance 0.91
PKC-epsilon-LI in ICC-DMP and translocation of PKC epsilon-LI in neurons were blocked by tetrodotoxin or atropine, suggesting that these responses were due to activation of muscarinic receptors.
Negative_regulation (blocked) of PKC-epsilon in neurons associated with tetrodotoxin
3) Confidence 0.39 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.14
These findings suggested that nPKCepsilon and NMDA receptors might participate in neuroprotection induced by morphine pretreatment, and NMDA receptors might be downstream targets of nPKCepsilon.
Negative_regulation (targets) of nPKCepsilon associated with nmda receptor and morphine
4) Confidence 0.36 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.14 Pain Relevance 0.79
By focusing on epsilonPKC and using a rational approach, we then identified one C2-derived peptide that acts as an isozyme-selective activator and another that acts as a selective inhibitor of epsilonPKC.
Negative_regulation (inhibitor) of epsilonPKC
5) Confidence 0.24 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142835 Disease Relevance 0.23 Pain Relevance 0.44

General Comments

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