INT110104

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Context Info
Confidence 0.79
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 3.75
Pain Relevance 6.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce) mitochondrion (Prkce) endoplasmic reticulum (Prkce)
plasma membrane (Prkce) nucleus (Prkce) enzyme binding (Prkce)
Anatomy Link Frequency
neurons 4
DRG 2
neuronal 1
interstitial cells 1
neural 1
Prkce (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 10 99.54 Very High Very High Very High
Morphine 18 99.48 Very High Very High Very High
dorsal root ganglion 15 99.08 Very High Very High Very High
Hyperalgesia 17 98.76 Very High Very High Very High
nMDA receptor 12 98.40 Very High Very High Very High
antagonist 9 98.32 Very High Very High Very High
tetrodotoxin 6 98.16 Very High Very High Very High
Pain 21 96.92 Very High Very High Very High
qutenza 7 96.90 Very High Very High Very High
nociceptor 7 94.24 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 19 99.08 Very High Very High Very High
Hyperalgesia 17 98.76 Very High Very High Very High
Reperfusion Injury 2 97.52 Very High Very High Very High
Injury 3 93.40 High High
Nociception 10 85.44 High High
Targeted Disruption 1 85.20 High High
INFLAMMATION 8 82.08 Quite High
Pain 8 79.96 Quite High
Inflammatory Pain 4 79.92 Quite High
Coronary Artery Disease 1 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Localization (translocation) of PKCepsilon
1) Confidence 0.79 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
Phosphorylation of PKCepsilon and TRPV1 and the cellular translocation of PKCepsilon from cytosol to membrane compartments were assessed by immunoblot analysis.
Localization (translocation) of PKCepsilon
2) Confidence 0.79 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.08 Pain Relevance 0
Electrical field stimulation or ACh caused translocation of neural PKC-epsilon-LI from the cytosol to a peripheral compartment.
Localization (translocation) of PKC-epsilon in neural
3) Confidence 0.74 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.12
In conclusion, PKC-epsilon translocation is linked to muscarinic receptor activation in ICC-DMP and a subpopulation of myenteric neurons.
Localization (translocation) of PKC-epsilon in neurons
4) Confidence 0.74 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.12
Western blots also confirmed translocation of PKC-epsilon-LI.
Localization (translocation) of PKC-epsilon
5) Confidence 0.74 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.13
PKC-epsilon translocation in enteric neurons and interstitial cells of Cajal in response to muscarinic stimulation.
Localization (translocation) of PKC-epsilon in neurons
6) Confidence 0.74 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.11
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Localization (translocation) of PKCepsilon
7) Confidence 0.74 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
Phosphorylation of PKCepsilon and TRPV1 and the cellular translocation of PKCepsilon from cytosol to membrane compartments were assessed by immunoblot analysis.
Localization (translocation) of PKCepsilon
8) Confidence 0.74 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.09 Pain Relevance 0
These findings indicate that NOX1/NADPH oxidase accelerates the translocation of PKCepsilon in DRG neurons, thereby enhancing the TRPV1 activity and the sensitivity to painful stimuli.
Localization (translocation) of PKCepsilon in DRG associated with pain
9) Confidence 0.71 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18799680 Disease Relevance 0.44 Pain Relevance 0.65
Concomitantly, PMA-induced translocation of PKCepsilon was markedly perturbed in Nox1(-/Y) or Nox1(+/Y) DRG neurons treated with ROS-scavenging agents.
Localization (translocation) of PKCepsilon in neurons
10) Confidence 0.71 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18799680 Disease Relevance 0.54 Pain Relevance 0.73
The signalling pathways were pharmacologically investigated with the pre-administration of adenylyl cyclase (AC), cAMP-dependent protein kinase (PKA), protein kinase Cepsilon (PKCepsilon), and the extracellular signal-related kinase (ERK) inhibitors.
Localization (administration) of PKCepsilon
11) Confidence 0.69 Published 2009 Journal Life Sci. Section Body Doc Link 19896488 Disease Relevance 0 Pain Relevance 0
The signalling pathways were pharmacologically investigated with the pre-administration of adenylyl cyclase (AC), cAMP-dependent protein kinase (PKA), protein kinase Cepsilon (PKCepsilon), and the extracellular signal-related kinase (ERK) inhibitors.
Localization (administration) of protein kinase Cepsilon
12) Confidence 0.69 Published 2009 Journal Life Sci. Section Body Doc Link 19896488 Disease Relevance 0 Pain Relevance 0
PKC-epsilon-LI in ICC-DMP and translocation of PKC epsilon-LI in neurons were blocked by tetrodotoxin or atropine, suggesting that these responses were due to activation of muscarinic receptors.
Localization (translocation) of PKC-epsilon in neurons associated with tetrodotoxin
13) Confidence 0.69 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.13
Morphine pretreatment significantly inhibited nPKCepsilon membrane translocation and phosphorylation of NR1 subunits of NMDA receptors during reperfusion injury.
Localization (translocation) of nPKCepsilon associated with reperfusion injury, nmda receptor and morphine
14) Confidence 0.67 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.17 Pain Relevance 0.99
At designated periods, slices were preserved for immunoblot analysis to observe effects of morphine pretreatment on membrane translocation and total protein expression of nPKCepsilon and phosphorylation of NR1 subunits of NMDA receptors.
Localization (translocation) of nPKCepsilon associated with nmda receptor and morphine
15) Confidence 0.63 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.15 Pain Relevance 0.95
Cardiol. 31, 1937-1948), and caused selective translocation of epsilonPKC over other isozymes when injected systemically into mice.
Localization (translocation) of epsilonPKC
16) Confidence 0.29 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142835 Disease Relevance 0.38 Pain Relevance 0.32
PKC-epsilon translocation in enteric neurons and interstitial cells of Cajal in response to muscarinic stimulation.
Localization (translocation) of PKC-epsilon in interstitial cells
17) Confidence 0.25 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.11
Bv8 enhanced the inward current carried by the heat and capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1) via a pathway involving activation of protein kinase Cepsilon (PKCepsilon), because Bv8 caused translocation of PKCepsilon to the neuronal membrane and because PKC antagonists reduced both the enhancement of current carried by TRPV1 and behavioral hyperalgesia in rodents.
Localization (translocation) of PKCepsilon in neuronal associated with hyperalgesia, qutenza and antagonist
18) Confidence 0.25 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16687502 Disease Relevance 0.49 Pain Relevance 0.90
Epac, in turn, was upstream of phospholipase C (PLC) and PLD, both of which were necessary for translocation and activation of PKCepsilon.
Localization (translocation) of PKCepsilon
19) Confidence 0.20 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15987941 Disease Relevance 0.55 Pain Relevance 0.37
Sar-SP also induced membrane translocation of PKCepsilon in a portion of small DRG neurons.
Localization (translocation) of PKCepsilon in DRG associated with dorsal root ganglion and substance p
20) Confidence 0.10 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978048 Disease Relevance 0.76 Pain Relevance 1.27

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