INT110106

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.40
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce) mitochondrion (Prkce) endoplasmic reticulum (Prkce)
plasma membrane (Prkce) nucleus (Prkce) enzyme binding (Prkce)
Anatomy Link Frequency
nerves 1
neural 1
Prkce (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 100.00 Very High Very High Very High
nMDA receptor 6 99.58 Very High Very High Very High
Morphine 9 98.92 Very High Very High Very High
alcohol 1 86.24 High High
Pain 2 82.56 Quite High
antagonist 3 78.76 Quite High
tetrodotoxin 1 58.40 Quite High
imagery 2 57.16 Quite High
Root ganglion neuron 1 55.36 Quite High
Kinase C 2 53.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 98.40 Very High Very High Very High
Nociception 2 97.84 Very High Very High Very High
Reperfusion Injury 1 89.92 High High
Ganglion Cysts 1 55.04 Quite High
Injury 1 54.76 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several neural functions of PKCepsilon, including neurotransmitter release and ion channel regulation, have been identified using PKCepsilon knockout mice.
Regulation (regulation) of PKCepsilon in neural associated with targeted disruption and neurotransmitter
1) Confidence 0.44 Published 2008 Journal FEBS J. Section Abstract Doc Link 18637121 Disease Relevance 0.10 Pain Relevance 0.18
Muscles were stimulated by intrinsic nerves and ACh and processed for immunohistochemistry to determine these effects on PKC-epsilon activation.
Regulation (effects) of PKC-epsilon in nerves
2) Confidence 0.41 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12711590 Disease Relevance 0 Pain Relevance 0.10
These findings suggested that nPKCepsilon and NMDA receptors might participate in neuroprotection induced by morphine pretreatment, and NMDA receptors might be downstream targets of nPKCepsilon.
Regulation (targets) of nPKCepsilon associated with nmda receptor and morphine
3) Confidence 0.23 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.14 Pain Relevance 0.79
This study, therefore, identifies PKCepsilon and S800 as important therapeutic targets that may help regulate inhibitory effects on TRPV1 and hence its desensitization.
Regulation (regulate) of PKCepsilon
4) Confidence 0.16 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.15 Pain Relevance 0.13

General Comments

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