INT11011

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 8
Speculated 9
Reported most in Abstract
Documents 190
Total Number 199
Disease Relevance 49.25
Pain Relevance 112.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
neurons 30
spinal cord 28
spinal 16
dorsal horn 16
sciatic nerve 14
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 726 100.00 Very High Very High Very High
Morphine 332 100.00 Very High Very High Very High
withdrawal 208 100.00 Very High Very High Very High
addiction 199 100.00 Very High Very High Very High
Inflammation 147 100.00 Very High Very High Very High
adenocard 109 100.00 Very High Very High Very High
amygdala 98 100.00 Very High Very High Very High
c fibre 54 100.00 Very High Very High Very High
Hyperalgesia 43 100.00 Very High Very High Very High
Calcitonin gene-related peptide 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 148 100.00 Very High Very High Very High
Hyperalgesia 96 100.00 Very High Very High Very High
Multiple Sclerosis 33 100.00 Very High Very High Very High
Stress 456 99.92 Very High Very High Very High
Ganglion Cysts 327 99.82 Very High Very High Very High
Neuropathic Pain 157 99.62 Very High Very High Very High
Injury 165 99.46 Very High Very High Very High
Repression 5 99.40 Very High Very High Very High
Shock 24 99.36 Very High Very High Very High
Hypertension 19 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological activation of the cAMP-CREB signaling with rolipram 24 hours before hypoxia protected rat pups at behavioral and pathological levels by sustained increased CREB phosphorylation.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB associated with hypoxia
1) Confidence 0.70 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15470752 Disease Relevance 0.43 Pain Relevance 0.07
The aim of this study is to determine whether increased phosphorylation of CREB in the dorsal horn contributes to the pathogenesis of neuropathic pain.
Spec (whether) Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB in dorsal horn associated with neuropathic pain and dorsal horn
2) Confidence 0.70 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.77 Pain Relevance 0.91
Partial nerve injury elicited neuropathic pain is accompanied by increased phosphorylation of CREB in the ipsilateral spinal cord dorsal horn (Ma and Quirion, Pain 93 (2001) 295; Miletic et al., Pain 99 (2002) 493).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB in spinal cord dorsal horn associated with pain, nervous system injury, dorsal horn, neuropathic pain and spinal cord
3) Confidence 0.70 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.71 Pain Relevance 0.83
Furthermore, our results indicate that CREB phosphorylation may be necessary but not sufficient for c-fos induction.
Neg (not) Spec (may) Positive_regulation (necessary) of Phosphorylation (phosphorylation) of CREB
4) Confidence 0.70 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.34 Pain Relevance 0.69
After a unilateral injection of formalin into the hindpaw, a strong and bilateral phosphorylation of CREB Ser133 was induced, as assessed by both immunohistochemistry and Western blot.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB
5) Confidence 0.70 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.64 Pain Relevance 0.48
CREB phosphorylation, not the level of CREB, was induced within 20 minutes by microdialysis administration of SIN-1, an NO donor.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB
6) Confidence 0.70 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.83
The mechanical hyperalgesia and phosphorylation of CREB depend on early activation of the cAMP pathway during the first 24 hr but are independent of the cAMP pathway by 1 week after intramuscular injection of acid.
Positive_regulation (depend) of Phosphorylation (phosphorylation) of CREB associated with hyperalgesia
7) Confidence 0.70 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12843242 Disease Relevance 0.46 Pain Relevance 0.63
The neuroprotective mechanisms were associated with increased CREB phosphorylation and increased brain-derived neurotrophic factor and synapsin I mRNA expression in the hippocampus.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus
8) Confidence 0.70 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16887358 Disease Relevance 1.08 Pain Relevance 0.76
KN-62 and staurosporine significantly blocked the opioids- induced CREB phosphorylation, while H-89 and PD 98059 had no effect on the actions.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB
9) Confidence 0.70 Published 2003 Journal Acta Pharmacol. Sin. Section Body Doc Link 14653953 Disease Relevance 0 Pain Relevance 0
This effect was reversed by naloxone, but F9203 failed to increase CREB phosphorylation.
Neg (failed) Positive_regulation (increase) of Phosphorylation (phosphorylation) of CREB
10) Confidence 0.70 Published 2003 Journal Acta Pharmacol. Sin. Section Body Doc Link 14653953 Disease Relevance 0 Pain Relevance 0
The increased CREB phosphorylation in hippocampal neurons may play a role in opioids dependence.


Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB in neurons
11) Confidence 0.70 Published 2003 Journal Acta Pharmacol. Sin. Section Body Doc Link 14653953 Disease Relevance 0 Pain Relevance 0
To determine if morphine withdrawal leads to increased CREB phosphorylation in striatal tissues, we examined the effects of naloxone-precipitated morphine withdrawal on CREB phosphorylation in primary cultures of rat striatal neurons.
Spec (determine) Positive_regulation (leads) of Phosphorylation (phosphorylation) of CREB in neurons associated with narcan, withdrawal and morphine
12) Confidence 0.69 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.09 Pain Relevance 1.28
Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of CREB in striatum associated with dopamine, withdrawal and morphine
13) Confidence 0.69 Published 2003 Journal J. Neurochem. Section Title Doc Link 12969258 Disease Relevance 0.08 Pain Relevance 1.13
One potential consequence of up-regulated cAMP signaling is increased phosphorylation of cAMP response element binding protein (CREB), a transcription factor that may regulate neuroadaptations related to morphine dependence.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of cAMP response element binding protein associated with addiction and morphine
14) Confidence 0.69 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.10 Pain Relevance 0.94
These results suggest that increased phosphorylation of CREB protein may contribute to central sensitization following acute peripheral noxious stimuli, and the effect may be regulated through the activation of CaM kinase cascades.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB associated with central sensitization
15) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631885 Disease Relevance 0 Pain Relevance 0.51
Intrathecal treatment with a CaM kinase II inhibitor, KN-93, significantly blocked the increased phosphorylation of CREB, but did not affect the CREB protein itself.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB associated with intrathecal
16) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631885 Disease Relevance 0 Pain Relevance 0.52
We have previously reported that intradermal capsaicin injection causes the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein (CREB) in the spinal cord of rats.
Positive_regulation (causes) of Phosphorylation (phosphorylation) of cyclic adenosine monophosphate-responsive element-binding protein in spinal cord associated with adenocard, qutenza and spinal cord
17) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631885 Disease Relevance 0 Pain Relevance 0.50
We found that capsaicin injection produces a significant upregulation of phosphorylated CREB in the spinal cord of rat.
Positive_regulation (upregulation) of Phosphorylation (phosphorylated) of CREB in spinal cord associated with qutenza and spinal cord
18) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631885 Disease Relevance 0 Pain Relevance 0.54
Furthermore, A1254-induced CREB phosphorylation occurs predominantly in neurons, is dependent on synaptic activity and mediated by Ca(2+)- and PKA-dependent pathways.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of CREB in neurons
19) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.13
Based on these results, we suggest that the increased phosphorylation of CREB in EAE lesions was mainly attributable to the infiltration of inflammatory cells and astrogliosis, possibly activating gene transcription, and that its increase in the sensory neurons in the dorsal horns is involved in the generation of neuropathic pain in the rat EAE model.
Spec (possibly) Positive_regulation (attributable) of Phosphorylation (phosphorylation) of CREB in sensory neurons associated with multiple sclerosis, inflammation and neuropathic pain
20) Confidence 0.68 Published 2007 Journal Brain Res. Section Abstract Doc Link 17617386 Disease Relevance 1.16 Pain Relevance 0.50

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