INT11012

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 8
Speculated 9
Reported most in Abstract
Documents 258
Total Number 267
Disease Relevance 84.40
Pain Relevance 132.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
spinal cord 21
hippocampus 16
neurons 12
brain 8
dorsal horn 6
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 1653 100.00 Very High Very High Very High
amygdala 1263 100.00 Very High Very High Very High
Opioid 443 100.00 Very High Very High Very High
Pain 365 100.00 Very High Very High Very High
bDMF 344 100.00 Very High Very High Very High
Inflammation 322 100.00 Very High Very High Very High
substance P 164 100.00 Very High Very High Very High
opioid receptor 98 100.00 Very High Very High Very High
Neuropathic pain 57 100.00 Very High Very High Very High
intrathecal 50 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1870 100.00 Very High Very High Very High
INFLAMMATION 295 100.00 Very High Very High Very High
Neuropathic Pain 109 100.00 Very High Very High Very High
Ganglion Cysts 104 100.00 Very High Very High Very High
Adhesions 16 100.00 Very High Very High Very High
Stress 2695 99.98 Very High Very High Very High
Opiate Addiction 47 99.98 Very High Very High Very High
Hyperalgesia 122 99.88 Very High Very High Very High
Nociception 523 99.84 Very High Very High Very High
Neurodegenerative Disease 207 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of cAMP response-element binding protein (CREB) and CREB-regulating signalling are considered main effectors in these mechanisms.
Positive_regulation (Activation) of cAMP response-element binding protein
1) Confidence 0.70 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0 Pain Relevance 0.21
Early induction of CREB activation and CREB-regulating signalling by antidepressants.
Positive_regulation (induction) of CREB associated with antidepressant
2) Confidence 0.70 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Title Doc Link 19400982 Disease Relevance 0.05 Pain Relevance 0.26
In hippocampus early and stronger CREB activation was consistent with early and stronger activation of signalling.
Positive_regulation (activation) of CREB in hippocampus associated with hippocampus
3) Confidence 0.70 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.10 Pain Relevance 0.36
The main aims of the study were to investigate how these different variables are modulated with time, whether stronger activation of signalling cascades corresponds to stronger activation of CREB, and whether these changes are different in distinct brain areas.
Spec (whether) Positive_regulation (activation) of CREB in brain
4) Confidence 0.70 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.07 Pain Relevance 0.32
We analysed the temporal profile of intracellular changes induced by antidepressants, by measuring activation of major CREB-regulating signalling cascades and activation (Ser133 phosphorylation) of CREB.
Positive_regulation (activation) of CREB associated with antidepressant
5) Confidence 0.70 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.05 Pain Relevance 0.27
Activation of cAMP response-element binding protein (CREB) and CREB-regulating signalling are considered main effectors in these mechanisms.
Positive_regulation (Activation) of CREB-regulating
6) Confidence 0.70 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0 Pain Relevance 0.21
Activation of cAMP response-element binding protein (CREB) and CREB-regulating signalling are considered main effectors in these mechanisms.
Positive_regulation (Activation) of CREB
7) Confidence 0.70 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0 Pain Relevance 0.21
The results also showed that, contrary to the activatory role of MAP-ERKs and CaM kinase IV, nuclear alphaCaM kinase II was inactivated in parallel with activation of CREB.
Positive_regulation (activation) of CREB
8) Confidence 0.70 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.08 Pain Relevance 0.30
Chronic treatment of fluoxetine, a selective serotonin reuptake inhibitor, can upregulate CREB activation in the hippocampus.
Positive_regulation (activation) of CREB in hippocampus associated with hippocampus, ssri and fluoxetine
9) Confidence 0.70 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16887358 Disease Relevance 1.00 Pain Relevance 0.75
Together, these data provide direct evidence that CREB plays an important role in controlling the electrical excitability of LC neurons and that morphine-induced increases in CREB activity contribute to the behavioral and neural adaptations associated with opiate dependence and withdrawal.
Positive_regulation (increases) of CREB in neural associated with addiction, locus ceruleus, opiate, withdrawal and morphine
10) Confidence 0.69 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16641242 Disease Relevance 0.10 Pain Relevance 0.77
Furthermore, they are consistent with in vivo evidence suggesting that increased CREB activation in portions of the striatum (e.g. the NAc) is related to dysphoric states associated with drug withdrawal.
Positive_regulation (activation) of CREB in striatum associated with nucleus accumbens and withdrawal
11) Confidence 0.69 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.06 Pain Relevance 1.25
The increased CREB activation associated with thermal hyperalgesia was accompanied by significant decreases in the content of both calcineurin Aalpha and Abeta.
Positive_regulation (activation) of CREB associated with thermal hyperalgesia and abeta
12) Confidence 0.69 Published 2002 Journal Pain Section Abstract Doc Link 12406525 Disease Relevance 0.95 Pain Relevance 1.03
In animals exhibiting thermal hyperalgesia as a behavioral sign of neuropathic pain 7 days after loose ligation of the sciatic nerve (chronic constriction injury), there was a significant increase in the content of phosphorylated (activated) CREB (pCREB).
Positive_regulation (increase) of CREB in sciatic nerve associated with eae, thermal hyperalgesia, injury, neuropathic pain and sciatic nerve
13) Confidence 0.69 Published 2002 Journal Pain Section Abstract Doc Link 12406525 Disease Relevance 0.94 Pain Relevance 0.99
We found that capsaicin injection produces a significant upregulation of phosphorylated CREB in the spinal cord of rat.
Positive_regulation (upregulation) of CREB in spinal cord associated with qutenza and spinal cord
14) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631885 Disease Relevance 0 Pain Relevance 0.54
Spinal activation of the cAMP induced gene transcription through the activation of protein kinase A and cAMP response element-binding protein (CREB).
Positive_regulation (activation) of cAMP response element-binding protein in Spinal associated with intrathecal
15) Confidence 0.69 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 18042889 Disease Relevance 0.27 Pain Relevance 0.62
Spinal activation of the cAMP induced gene transcription through the activation of protein kinase A and cAMP response element-binding protein (CREB).
Positive_regulation (activation) of CREB in Spinal associated with intrathecal
16) Confidence 0.69 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 18042889 Disease Relevance 0.27 Pain Relevance 0.62
In addition, the current results replicated our previous finding that activated CREB is upregulated following SCI, however, only in SCI rats that developed CNP.
Positive_regulation (activated) of CREB associated with frailty
17) Confidence 0.69 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16478624 Disease Relevance 0.97 Pain Relevance 0.48
Increases in the activated forms of ERK 1/2, p38 MAPK, and CREB are correlated with the expression of at-level mechanical allodynia following spinal cord injury.
Positive_regulation (Increases) of CREB in spinal cord associated with hyperesthesia, allodynia and spinal cord
18) Confidence 0.69 Published 2006 Journal Exp. Neurol. Section Title Doc Link 16478624 Disease Relevance 0.89 Pain Relevance 0.66
change in transmission due to CREB induction in the right hemisphere.
Positive_regulation (induction) of CREB
19) Confidence 0.69 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.35 Pain Relevance 0.81
The results indicate that PKC mediates both CREB activation and HPA response by morphine withdrawal and might suggest that CREB activation in the NTS is related to TH expression associated with morphine withdrawal.
Positive_regulation (activation) of CREB associated with kinase c, withdrawal and morphine
20) Confidence 0.69 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.15 Pain Relevance 1.05

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