INT110136

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.48
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
uterus 6
PVN 4
brain 2
SON 2
uterine 2
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 27 99.98 Very High Very High Very High
fluoxetine 6 99.96 Very High Very High Very High
Intracerebroventricular 6 90.72 High High
Serotonin 6 90.52 High High
Neurotransmitter 3 90.12 High High
Dismenorea 6 89.44 High High
Potency 18 67.88 Quite High
antagonist 6 5.00 Very Low Very Low Very Low
epidural 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 96.52 Very High Very High Very High
Dysmenorrhea 6 89.44 High High
Obesity 12 24.48 Low Low
Hypersensitivity 24 5.00 Very Low Very Low Very Low
Breast Cancer 6 5.00 Very Low Very Low Very Low
Reprotox - General 1 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low
Weight Loss 2 5.00 Very Low Very Low Very Low
Birth Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In male Wistar rats, we investigated the 5-HT receptors involved in the 5-HT-induced increase of mRNA expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).
Positive_regulation (increase) of Transcription (expression) of oxytocin in SON
1) Confidence 0.39 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0.10 Pain Relevance 0.34
We conclude that stimulation with 5-hydroxytryptophan or 5-HT agonists increases mRNA expression of oxytocin in the PVN and the SON via stimulation of at least 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptors.
Positive_regulation (increases) of Transcription (expression) of oxytocin in PVN associated with agonist
2) Confidence 0.28 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0 Pain Relevance 0.44
The 5-HT precursor, 5-hydroxytryptophan, injected in combination with the 5-HT reuptake inhibitor, fluoxetine, increased oxytocin mRNA expression in the PVN, and the concentration of vasopressin and oxytocin in plasma, whereas mRNA in the SON was not affected.
Positive_regulation (increased) of Transcription (expression) of oxytocin in PVN associated with fluoxetine
3) Confidence 0.26 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0.09 Pain Relevance 0.44
Animal studies show that in ewes, the first pregnancy induces permanent changes with regard to the release of oxytocin and oxytocin receptors, e.g. the expression of oxytocin receptor mRNA is increased in the paraventricular nucleus (PVN) of the brain and the sensitivity of oxytocin autoreceptors is increased [29].
Positive_regulation (increased) of Transcription (expression) of oxytocin in brain
4) Confidence 0.24 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1878468 Disease Relevance 0 Pain Relevance 0
In parallel with CaBP-9k mRNA, the expression levels of oxytocin (13.4-fold, vs. luteal phase), Acrp30 (3.1-fold, vs. luteal phase), Ldha (3.3-fold, vs. luteal phase), and S100a6 (2.7-fold, vs. luteal phase) mRNAs at follicular phase were up-regulated in this tissue, indicating that they are dominantly expressed during follicular phase and weakly detected at luteal phase in the uterus of mature rats.


Positive_regulation (regulated) of Transcription (expression) of oxytocin in uterus
5) Confidence 0.10 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
In parallel with CaBP-9k mRNA, the expression levels of oxytocin (13.4-fold, vs. luteal phase), Acrp30 (3.1-fold, vs. luteal phase), Ldha (3.3-fold, vs. luteal phase), and S100a6 (2.7-fold, vs. luteal phase) mRNAs at follicular phase were up-regulated in this tissue, indicating that they are dominantly expressed during follicular phase and weakly detected at luteal phase in the uterus of mature rats.


Positive_regulation (up) of Transcription (expression) of oxytocin in uterus
6) Confidence 0.10 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
These observations raise the possibility that the increase in the oxytocin mRNA level shown in Figure 3, occurs, at least in part, as a result of the injected estrogenic compounds and that the PCR data and microarray data are in general agreement.
Positive_regulation (increase) of Transcription (level) of oxytocin
7) Confidence 0.10 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.07 Pain Relevance 0.07
Based on the treatments with EDs, increased expression levels of oxytocin mRNA were observed when rats were treated with OP (14.76-fold) and NP (9.54-fold), and a single dose treatment with DES (5.70-fold) and E2 (5.83-fold) for 3 days.
Positive_regulation (increased) of Transcription (levels) of oxytocin
8) Confidence 0.10 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.09 Pain Relevance 0.09
Estrogen stimulated the number of uterine oxytocin binding sites, and oxytocin receptor mRNA expression in ovariectomized virgin rats [39,40].
Positive_regulation (stimulated) of Transcription (expression) of oxytocin in uterine
9) Confidence 0.10 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.07 Pain Relevance 0.14
The mRNA levels of oxytocin increased 2-fold between metestrus and proestrus by Northern blot analysis during estrous cycle, while oxytocin binding increased more than 10-fold within this same interval in the uterus of rats [40].
Positive_regulation (increased) of Transcription (levels) of oxytocin in uterus
10) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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