INT11015

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Context Info
Confidence 0.46
First Reported 1992
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.45
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
nerve 2
DRG 2
locus coeruleus 2
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 99.98 Very High Very High Very High
GABA receptor 10 99.54 Very High Very High Very High
qutenza 1 99.00 Very High Very High Very High
opiate 10 98.76 Very High Very High Very High
Pain 1 98.68 Very High Very High Very High
Inflammation 3 98.48 Very High Very High Very High
nMDA receptor 6 98.42 Very High Very High Very High
Locus ceruleus 4 98.32 Very High Very High Very High
allodynia 2 98.28 Very High Very High Very High
Neuropathic pain 4 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cystitis 9 99.70 Very High Very High Very High
Pain 1 98.68 Very High Very High Very High
INFLAMMATION 3 98.48 Very High Very High Very High
Neuropathic Pain 6 98.28 Very High Very High Very High
Nervous System Injury 5 96.08 Very High Very High Very High
Hypersensitivity 1 25.00 Low Low
Intellectual Impairment 4 5.00 Very Low Very Low Very Low
Autism 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low
Paralysis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alcohol may disrupt orientation selectivity by acutely suppressing NMDA receptor function [10], [23], [68] while enhancing GABA receptor function [69] thereby affecting CREB phosphorylation [70]–[72].
Regulation (affecting) of Phosphorylation (phosphorylation) of CREB associated with gaba receptor, nmda receptor and alcohol
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.40
To further evaluate changes in CREB phosphorylation we compared pCREB/GAPDH levels of Ethanol and Ethanol+Vinpocetine animals to their controls (Figure 4c).
Regulation (changes) of Phosphorylation (phosphorylation) of CREB
2) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0
The present study examined the roles of cyclic AMP response element-binding protein and of the phosphorylated cyclic AMP response element-binding protein in the maintenance of mechanical and cold allodynia induced by a neuropathic pain model, "spared nerve injury," in rats.
Spec (examined) Regulation (roles) of Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in nerve associated with nervous system injury, allodynia and neuropathic pain
3) Confidence 0.45 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.87 Pain Relevance 0.67
Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus.
Regulation (Regulation) of Phosphorylation (phosphorylation) of cyclic AMP response element-binding protein in locus coeruleus associated with locus ceruleus and morphine
4) Confidence 0.29 Published 1992 Journal J. Neurochem. Section Title Doc Link 1531356 Disease Relevance 0 Pain Relevance 1.01
To understand better the mechanism by which opiates produce these intracellular adaptations, we studied morphine regulation of the state of phosphorylation of cyclic AMP response element-binding protein (CREB), a transcription factor that mediates some of the effects of the cyclic AMP system on gene expression.
Regulation (regulation) of Phosphorylation (phosphorylation) of cyclic AMP response element-binding protein associated with opiate and morphine
5) Confidence 0.21 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1531356 Disease Relevance 0 Pain Relevance 1.00
Resiniferatoxin reduced CYP-induced up-regulation of p-CREB in DRG, suggesting that cystitis can reveal an altered CREB phosphorylation that may be mediated by capsaicin-sensitive bladder afferents.
Regulation (altered) of Phosphorylation (phosphorylation) of CREB in DRG associated with qutenza and cystitis
6) Confidence 0.02 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14694538 Disease Relevance 0.58 Pain Relevance 0.10

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