INT110163

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.71
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQB1) Golgi apparatus (HLA-DQB1) endoplasmic reticulum (HLA-DQB1)
plasma membrane (HLA-DQB1) intracellular (HLA-DQB1)
Anatomy Link Frequency
monocytes 1
HLA-DQB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 55 99.98 Very High Very High Very High
Inflammation 106 98.52 Very High Very High Very High
Migraine 6 98.36 Very High Very High Very High
Arthritis 30 93.04 High High
rheumatoid arthritis 101 72.52 Quite High
Multiple sclerosis 24 66.72 Quite High
Inflammatory response 5 55.64 Quite High
Chronic pancreatitis 2 50.00 Quite Low
spinal inflammation 17 20.92 Low Low
chemokine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 2 100.00 Very High Very High Very High
Disease 93 99.76 Very High Very High Very High
Diabetes Mellitus 109 99.40 Very High Very High Very High
INFLAMMATION 115 98.52 Very High Very High Very High
Headache 6 98.36 Very High Very High Very High
Autoimmune Disease 97 97.72 Very High Very High Very High
Epilepsy 2 94.00 High High
Arthritis 23 93.04 High High
Systemic Lupus Erythematosus 12 82.24 Quite High
Infection 16 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HLA-DQB1 risk genotype was associated with decreased risk for macrovascular disease in type 1 diabetic patients (OR 0.49[0.28–0.86], p?
HLA-DQB1 Binding (associated) of associated with diabetes mellitus and disease
1) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.14 Pain Relevance 0
Neither HLA-B nor HLA-DQB1 associations with the disease were found.
HLA-DQB1 Neg (nor) Binding (associations) of
2) Confidence 0.15 Published 2003 Journal Pancreas Section Body Doc Link 12717273 Disease Relevance 0 Pain Relevance 0
In GD this approach was successful in determining that DQB1 was unable to explain association with disease, narrowing down the location of the etiological variant within the class II region to either DRB1 or DQA1 [32].
DQB1 Neg (unable) Binding (association) of associated with disease
3) Confidence 0.11 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.44 Pain Relevance 0.06
A stronger association with the DQB1 locus alone was reported when an allele encoding aspartic acid (Asp) at position ?
DQB1 Binding (association) of
4) Confidence 0.11 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.47 Pain Relevance 0
PURPOSE: Since the regions DR and DQ of the HLA are in tightly linkage desiquilibrium we hypothesize that HLA-DQB1*0602 might be associated to the pathophysiology of migraine.
HLA-DQB1 Spec (might) Binding (associated) of
5) Confidence 0.11 Published 2007 Journal Arq Neuropsiquiatr Section Body Doc Link 18345414 Disease Relevance 0.10 Pain Relevance 0
HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy.
HLA-DQB1 Binding (associated) of associated with sleep disorders
6) Confidence 0.11 Published 2007 Journal Arq Neuropsiquiatr Section Abstract Doc Link 18345414 Disease Relevance 0.37 Pain Relevance 0.26
Finally, the staphylococcal enterotoxin A increases the expression of the Toll-like receptor (TLR)-4 in human monocytes by ligation of major histocompatibility complex-II, with subsequent enhancement of pro-inflammatory cytokines by known TLR-4 ligands (for example, LPS [28]).
major histocompatibility complex-II Binding (ligation) of in monocytes associated with inflammation and cytokine
7) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.65 Pain Relevance 0.36
CD74's main molecular function is cytokine binding, and both CD74 and HLA-DQB are involved in the antigen presentation canonical pathway and in the immune response.
HLA-DQB Binding (binding) of associated with cytokine
8) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.56 Pain Relevance 0.30
The range values are 0.163 for HLA markers DPA1-DQB1 and 0.712 for DQB1-DRB1 (Table 2).
DPA1-DQB1 Binding (0.163) of
9) Confidence 0.03 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883542 Disease Relevance 0 Pain Relevance 0

General Comments

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