INT110165

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.21
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Arg1) aging (Arg1) cytoplasm (Arg1)
Anatomy Link Frequency
macrophages 1
vasculature 1
vagina 1
kidney 1
Arg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 1 97.96 Very High Very High Very High
anesthesia 5 97.64 Very High Very High Very High
midbrain 2 84.56 Quite High
Glutamate 76 61.20 Quite High
Pain 11 50.88 Quite High
addiction 1 18.08 Low Low
Neurotransmitter 3 12.00 Low Low
ischemia 38 5.00 Very Low Very Low Very Low
imagery 28 5.00 Very Low Very Low Very Low
cerebral cortex 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Disorder 1 99.78 Very High Very High Very High
Arginase Deficiency 1 99.30 Very High Very High Very High
Reperfusion Injury 2 99.00 Very High Very High Very High
Hypoxia 63 98.00 Very High Very High Very High
Stress 16 93.40 High High
Myocardial Infarction 2 91.72 High High
Acute Renal Failure 9 86.88 High High
Brain Injury 2 85.92 High High
Infarction 26 80.20 Quite High
Rhabdomyolysis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tamoxifen treatment increased ER levels in the vagina and decreased arginase activity (figures 4 &5).
Negative_regulation (decreased) of arginase in vagina
1) Confidence 0.38 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0 Pain Relevance 0
Melatonin had an increasing effect on kidney tissue arginase activities and ornithine levels while decreasing NO concentration.
Neg (NO) Negative_regulation (decreasing) of arginase in kidney
2) Confidence 0.31 Published 2006 Journal Ren Fail Section Abstract Doc Link 16825094 Disease Relevance 0.78 Pain Relevance 0.09
Similar to ovariectomized animals, estrogen receptor binding was increased and arginase enzyme activity was decreased in tamoxifen-infused rats.
Negative_regulation (decreased) of arginase
3) Confidence 0.28 Published 2006 Journal BMC Womens Health Section Abstract Doc Link PMC1590006 Disease Relevance 0.10 Pain Relevance 0.05
The decrease in arginase activity in tamoxifen-infused rats may be reflective of a compensatory down-regulation in the local vasculature to maintain vaginal perfusion.
Negative_regulation (decrease) of arginase in vasculature
4) Confidence 0.28 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.07 Pain Relevance 0
Hyperargininemia is a metabolic disorder caused by deficiency of arginase activity resulting in tissue accumulation of arginine and neurological dysfunction.
Negative_regulation (deficiency) of arginase associated with metabolic disorder, anesthesia and arginase deficiency
5) Confidence 0.13 Published 2003 Journal Neurochem. Res. Section Abstract Doc Link 12718434 Disease Relevance 0.34 Pain Relevance 0.18
The increased arginase and sustained decrease of GS activity in reperfusion group are likely to be protective.



Negative_regulation (decrease) of arginase
6) Confidence 0.11 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.77 Pain Relevance 0.09
In addition, lysine is a potent inhibitor of arginase and hence blocks arginase-mediated urea synthesis from arginine (Egan et al., 1995).
Negative_regulation (inhibitor) of arginase
7) Confidence 0.09 Published 2010 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2892957 Disease Relevance 0.57 Pain Relevance 0.03
In addition, lysine is a potent inhibitor of arginase and hence blocks arginase-mediated urea synthesis from arginine (Egan et al., 1995).
Negative_regulation (blocks) of arginase-mediated
8) Confidence 0.06 Published 2010 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2892957 Disease Relevance 0.58 Pain Relevance 0
Although, the unique and relatively potent inhibition of arginase by the biosynthetic intermediate in NO generation, NG-hydroxy-L-arginine suggests an alternate means of regulation in tissues and cells (such as macrophages), that contain both NOS and arginase [35].
Negative_regulation (inhibition) of arginase in macrophages
9) Confidence 0.04 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0.05

General Comments

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