INT110188

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.85
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnaq) signal transduction (Gnaq) plasma membrane (Gnaq)
GTPase activity (Gnaq) protein complex (Gnaq) signal transducer activity (Gnaq)
Anatomy Link Frequency
nucleus 2
Gnaq (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 15 97.76 Very High Very High Very High
agonist 1 86.68 High High
antidepressant 1 78.80 Quite High
Serotonin 2 75.00 Quite High
depression 3 73.44 Quite High
Disease Link Frequency Relevance Heat
Stress 12 93.16 High High
Urological Neuroanatomy 3 75.00 Quite High
Depression 3 73.44 Quite High
Anxiety Disorder 1 43.64 Quite Low
Sprains And Strains 1 42.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that compensatory changes in G alpha q expression occur in mice with persistently altered 5-HT2C pre-mRNA editing and provide an explanation for the dissociation between 5-HT2C receptor editing phenotypes and behavioral stress responses.
Regulation (changes) of Gene_expression (expression) of alpha q associated with stress
1) Confidence 0.25 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17287521 Disease Relevance 0.78 Pain Relevance 0.42
Regulators of G protein signaling 4 and Galphaq protein levels in the hypothalamic paraventricular nucleus were not altered during fluoxetine treatment.
Regulation (Regulators) of Gene_expression (levels) of Galphaq protein in nucleus associated with fluoxetine
2) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721328 Disease Relevance 0.07 Pain Relevance 0.80

General Comments

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