INT110201

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.25
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sbp) molecular_function (Sbp) biological_process (Sbp)
Anatomy Link Frequency
blood 3
brain 1
Sbp (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 12 99.36 Very High Very High Very High
agonist 14 98.92 Very High Very High Very High
Antinociceptive 12 92.00 High High
dexamethasone 4 68.48 Quite High
alcohol 4 60.92 Quite High
Calcium channel 4 53.20 Quite High
antagonist 35 51.92 Quite High
cva 4 37.20 Quite Low
ischemia 3 34.08 Quite Low
Analgesic 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 4 99.38 Very High Very High Very High
Hypertension 325 99.20 Very High Very High Very High
Sprains And Strains 358 99.04 Very High Very High Very High
Coronary Artery Disease 22 98.34 Very High Very High Very High
Heart Rate Under Development 36 98.24 Very High Very High Very High
Diabetes Mellitus 19 98.14 Very High Very High Very High
Dizziness 4 96.56 Very High Very High Very High
Pressure And Volume Under Development 65 96.36 Very High Very High Very High
Increased Venous Pressure Under Development 9 94.60 High High
Emergencies 12 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The i.c.v. pretreatment with SMTC also reduced N2O antinociception and brain NOS activity without increasing of SBP.
Neg (without) Positive_regulation (increasing) of SBP in brain associated with antinociception
1) Confidence 0.49 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721331 Disease Relevance 0 Pain Relevance 0.42
Moreover, in blood pressure experiments, SMTC increased SBP in dose-unrelated fashion, whereas l-NIO showed an appreciably weaker but dose-related increase in SBP.
Positive_regulation (increase) of SBP in blood
2) Confidence 0.49 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721331 Disease Relevance 0 Pain Relevance 0.45
Moreover, in blood pressure experiments, SMTC increased SBP in dose-unrelated fashion, whereas l-NIO showed an appreciably weaker but dose-related increase in SBP.
Positive_regulation (increased) of SBP in blood
3) Confidence 0.33 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721331 Disease Relevance 0 Pain Relevance 0.45
As for iso10, it tended to slightly increase SBP in the majority of the strains, perhaps as a consequence of increased cardiac inotropy, but the trend was significant in a single line (i.e.
Positive_regulation (increase) of SBP associated with sprains and strains
4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.66 Pain Relevance 0
Modest hemodynamic changes in response to iso are consistent with previous data obtained in rats [20] and mice [13], confirming that cardiac hypertrophy induced by iso is essentially independent of SBP.


Neg (independent) Positive_regulation (independent) of SBP associated with coronary heart disease
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.80 Pain Relevance 0
Although in our experiments, an acute treatment with phenylephrine rapidly increases SBP in C animals, only a slight increase was observed for LP offspring.
Positive_regulation (increases) of SBP
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 0.89 Pain Relevance 0.08
1-adrenoceptor agonist that also increases blood pressure produced a slight increase in SBP but an important rise of HR in C animals (Figure 3E–F).
Positive_regulation (increase) of SBP in blood associated with agonist
7) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 0.12 Pain Relevance 0.05
The baseline systolic BP (SBP) is significantly elevated in APA?
Positive_regulation (elevated) of SBP
8) Confidence 0.10 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.55 Pain Relevance 0
In cases of a markedly elevated SBP, an initial goal of <160 mmHg is reasonable, provided there is no evidence of target organ damage, or signs or symptoms of a hypertensive emergency.
Positive_regulation (elevated) of SBP associated with emergencies and hypertension
9) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.21 Pain Relevance 0
In addition to the nonpharmacologic interventions discussed, a general approach to antihypertensive therapy includes the use of agents based on a patient’s comorbidities (eg, diabetes, CHF, CAD), a low-dose diuretic in uncomplicated HTN, starting at half the usual dosage and increasing slowly, a focus on SBP, avoiding excessive lowering of DBP, and accounting for individual patient goals (Table 3).
Positive_regulation (increasing) of SBP associated with heart rate under development, coronary artery disease, diabetes mellitus and hypertension
10) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.02 Pain Relevance 0.11

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