INT110202

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.08
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
bile 4
intestine 3
vessels 2
brain 2
hematopoietic cells 2
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 101 99.74 Very High Very High Very High
Hippocampus 4 99.68 Very High Very High Very High
Morphine 35 99.62 Very High Very High Very High
Oxycodone 18 99.56 Very High Very High Very High
Analgesic 4 99.36 Very High Very High Very High
agonist 22 91.52 High High
tolerance 8 91.36 High High
addiction 1 89.24 High High
Antinociceptive 2 71.88 Quite High
nMDA receptor antagonist 1 69.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 64 96.28 Very High Very High Very High
Disease 23 92.96 High High
Drug Induced Neurotoxicity 2 84.12 Quite High
Nephrotoxicity 2 82.68 Quite High
Cancer 160 79.96 Quite High
Colon Cancer 19 79.00 Quite High
Infection 32 78.76 Quite High
Chondrosarcoma 52 71.76 Quite High
Liver Disease 6 69.04 Quite High
Rickets 16 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Potential P-gp inducers (rifampin and morphine) were administered subchorionically to P-gp-competent [mdr1a(+/+)] mice to induce P-gp expression in brain; the impact of rifampin pretreatment on brain penetration of verapamil also was evaluated with an in situ brain perfusion technique.
Positive_regulation (induce) of Gene_expression (expression) of P-gp in brain associated with morphine
1) Confidence 0.67 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721332 Disease Relevance 0 Pain Relevance 0.22
These mice completely lack phospholipids in their bile [67], but the bile PC is fully recovered with the overexpression of h-MDR3 [68].
Positive_regulation (recovered) of Gene_expression (overexpression) of h-MDR3 in bile associated with bile
2) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.26 Pain Relevance 0.14
These mice completely lack phospholipids in their bile [67], but the bile PC is fully recovered with the overexpression of h-MDR3 [68].
Positive_regulation (overexpression) of Gene_expression (overexpression) of h-MDR3 in bile associated with bile
3) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.26 Pain Relevance 0.14
These findings display that oxycodone is a P-gp substrate, induces overexpression of P-gp, and affects paclitaxel's tissue distribution in a manner that may influence its chemotherapeutic activity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of P-gp associated with oxycodone
4) Confidence 0.24 Published 2007 Journal J Pharm Sci Section Abstract Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.75
These findings display that oxycodone is a P-gp substrate, induces overexpression of P-gp, and affects paclitaxel's tissue distribution in a manner that may influence its chemotherapeutic activity.
Positive_regulation (induces) of Gene_expression (overexpression) of P-gp associated with oxycodone
5) Confidence 0.24 Published 2007 Journal J Pharm Sci Section Abstract Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.76
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Positive_regulation (induced) of Gene_expression (expression) of MDR1a in intestine
6) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
In contrast, the authors' data suggest that the mechanism of oxymatrine enhancement of morphine's analgesic effects is not associated with increase in the level of expression of P-gp.
Positive_regulation (increase) of Gene_expression (expression) of P-gp associated with analgesic and morphine
7) Confidence 0.14 Published 2010 Journal Integr Cancer Ther Section Abstract Doc Link 20587445 Disease Relevance 0 Pain Relevance 1.26
Using siRNA, Kim et al. showed that knocking down the expression of MDR-1 increased chemosensitivity by up to 4.1 fold [12].
Positive_regulation (increased) of Gene_expression (expression) of MDR-1
8) Confidence 0.11 Published 2011 Journal Sarcoma Section Body Doc Link PMC3018623 Disease Relevance 0.22 Pain Relevance 0.06
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Positive_regulation (induced) of in liver Gene_expression (expression) of MDR1a in intestine
9) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
An increase in the BMCs expression of P-gp was seen.
Positive_regulation (increase) of Gene_expression (expression) of P-gp
10) Confidence 0.06 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.34 Pain Relevance 0
Our preliminary studies in mice indicated that, transfection of MDR1 retroviral vectors resulted in a significant increase in P-gp expression in murine bone marrow cells, transplantation of which into recipients resulted in consistently high levels of MDRl expression in developing hematopoietic cells after treatment and protecting the normal BMCs from the toxic effects of anticancer drugs[7,8].
Positive_regulation (increase) of Gene_expression (expression) of P-gp in hematopoietic cells
11) Confidence 0.05 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.70 Pain Relevance 0
Immunohistofluorescence experiments revealed that P-gp expression is restricted to large vessels and microvessels in control rats and that morphine treatment did not induce the expression of P-gp in the brain parenchyma (astrocytes or neurons).
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of P-gp in vessels associated with morphine
12) Confidence 0.02 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.81
Immunoblotting revealed an increase in P-gp expression in the hippocampus (1.8-fold) and cortex (1.36-fold) of morphine-treated rats, but no effect in isolated microvessels.
Positive_regulation (increase) of Gene_expression (expression) of P-gp in hippocampus associated with hippocampus and morphine
13) Confidence 0.02 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.79

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