INT11021

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Context Info
Confidence 0.52
First Reported 1992
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 8.54
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
olfactory mucosa 3
olfactory bulb 2
vomeronasal organ 1
cilia 1
anterior 1
Tme (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 60 85.20 High High
hyperexcitability 2 81.16 Quite High
Hyperesthesia 12 78.40 Quite High
imagery 67 76.56 Quite High
anesthesia 11 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Encephalopathy 768 100.00 Very High Very High Very High
Infection 671 100.00 Very High Very High Very High
Overactive Bladder 5 100.00 Very High Very High Very High
Sprains And Strains 36 97.94 Very High Very High Very High
Disease 104 97.68 Very High Very High Very High
Rectal Cancer 92 96.32 Very High Very High Very High
Anastomotic Leak 14 93.08 High High
Scrapie 230 90.80 High High
Cancer 110 88.76 High High
Flatulence 1 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of the HY and DY strains of agent that retain their biological characteristics on repeated hamster passage in the Stetsonville TME source requires that the informational molecule encoding these transmissible agents has the capacity to account for this biological diversity.
Gene_expression (source) of TME associated with encephalopathy and sprains and strains
1) Confidence 0.52 Published 1992 Journal J. Gen. Virol. Section Abstract Doc Link 1531675 Disease Relevance 1.05 Pain Relevance 0.10
This suggests that the DY agent is the major mink pathogen in the Stetsonville TME source that is also pathogenic in hamsters after a long incubation period.
Gene_expression (source) of TME associated with encephalopathy
2) Confidence 0.52 Published 1992 Journal J. Gen. Virol. Section Abstract Doc Link 1531675 Disease Relevance 1.33 Pain Relevance 0.12
Voiding and sexual function between laparoscopy and robot rectal TME
Gene_expression (Voiding) of TME associated with overactive bladder
3) Confidence 0.39 Published 2010 Journal Journal of the Korean Society of Coloproctology Section Body Doc Link PMC3017972 Disease Relevance 0.55 Pain Relevance 0
In those patients with low anterior resection with TME, post-operative radiation was not given during the initial period of the study and postoperative chemotherapy was offered to those with stage II or stage III disease.
Gene_expression (resection) of TME in anterior associated with disease
4) Confidence 0.26 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2859360 Disease Relevance 0.67 Pain Relevance 0.08
To investigate the amount of HY TME infection in the olfactory mucosa following i.c. and i.ob. inoculation, TME infectivity in lysates from the olfactory bulb and olfactory mucosa extracted from nasal turbinates were measured using a hamster bioassay.
Spec (investigate) Gene_expression (infection) of HY TME in olfactory bulb associated with encephalopathy and infection
5) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.52 Pain Relevance 0
To investigate the amount of HY TME infection in the olfactory mucosa following i.c. and i.ob. inoculation, TME infectivity in lysates from the olfactory bulb and olfactory mucosa extracted from nasal turbinates were measured using a hamster bioassay.
Gene_expression (infectivity) of TME in olfactory bulb associated with encephalopathy and infection
6) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.41 Pain Relevance 0
This dilution of hamster brain corresponds to approximately six LD50 of HY TME agent, while additional reactions from 10?
Gene_expression (agent) of HY TME in brain associated with encephalopathy
7) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.63 Pain Relevance 0
The vomeronasal organ (VNO), which is a chemoreceptive structure at the base of the nasal septum, was another sensory structure that had evidence of HY TME infection following i.ob. inoculation.
Gene_expression (infection) of HY TME in vomeronasal organ associated with encephalopathy and infection
8) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.38 Pain Relevance 0
To investigate the spread of HY TME infection into the nasal cavity following i.ob. inoculation, LSCM was used to localize PrPSc deposition in the nasal cavity.
Spec (investigate) Gene_expression (infection) of HY TME in nasal cavity associated with encephalopathy and infection
9) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.20 Pain Relevance 0
These studies suggest that the majority of PrPSc in the region of the apical dendrites co-localize with sensory cilia and suggest that HY TME infection can be established in the cilia of ORNs.
Gene_expression (infection) of HY TME in cilia associated with encephalopathy and infection
10) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.37 Pain Relevance 0
Animal bioassay for TME infectivity
Gene_expression (infectivity) of TME associated with encephalopathy
11) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.26 Pain Relevance 0
So, there are likely a greater number of neurons in the OSE than the olfactory bulb and this dense concentration of potential replication sites in the olfactory epithelium could explain the high HY TME infectivity and PrPSc levels in the olfactory mucosa.
Gene_expression (levels) of HY TME in olfactory mucosa associated with encephalopathy
12) Confidence 0.18 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.55 Pain Relevance 0.04
To investigate the amount of HY TME infection in the olfactory mucosa following i.c. and i.ob. inoculation, TME infectivity in lysates from the olfactory bulb and olfactory mucosa extracted from nasal turbinates were measured using a hamster bioassay.
Spec (investigate) Gene_expression (infection) of HY TME in olfactory mucosa associated with encephalopathy and infection
13) Confidence 0.08 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.52 Pain Relevance 0
To investigate the amount of HY TME infection in the olfactory mucosa following i.c. and i.ob. inoculation, TME infectivity in lysates from the olfactory bulb and olfactory mucosa extracted from nasal turbinates were measured using a hamster bioassay.
Gene_expression (infectivity) of TME in olfactory mucosa associated with encephalopathy and infection
14) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.41 Pain Relevance 0
The widespread introduction of TME has markedly reduced the rate of non-continence-preserving abdominoperineal operations for rectal cancer.
Gene_expression (introduction) of TME associated with rectal cancer
15) Confidence 0.06 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1779628 Disease Relevance 0.68 Pain Relevance 0

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