INT110210

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 8.96
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CSRP1)
Anatomy Link Frequency
coronary artery 1
leukocytes 1
skin 1
CSRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 2 99.32 Very High Very High Very High
spinal inflammation 3 97.52 Very High Very High Very High
corticosteroid 6 96.20 Very High Very High Very High
imagery 5 95.12 Very High Very High Very High
rheumatoid arthritis 16 92.96 High High
aspirin 11 92.88 High High
Restless leg syndrome 60 92.44 High High
Inflammation 90 88.60 High High
Osteoarthritis 1 84.48 Quite High
Pain 14 81.72 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 2 99.32 Very High Very High Very High
Ulcers 10 99.04 Very High Very High Very High
Myocardial Infarction 8 98.16 Very High Very High Very High
Seronegative Spondarthritis 4 97.52 Very High Very High Very High
Leukocytosis 3 94.20 High High
Infection 12 93.84 High High
Mrsa Infection 11 93.44 High High
Rheumatoid Arthritis 16 92.96 High High
Increased Venous Pressure Under Development 66 92.44 High High
Fever 18 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the second cycle, the levels of leukocytes and CRP were remarkably decreased, and the severe back pain was also alleviated.
Negative_regulation (decreased) of CRP in leukocytes associated with backache
1) Confidence 0.59 Published 2003 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 12722684 Disease Relevance 0.54 Pain Relevance 0.19
Serum CRP level then decreased and in October skin grafting was once again undertaken, this time the graft successfully survived.
Negative_regulation (decreased) of CRP in skin
2) Confidence 0.58 Published 2008 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 18446015 Disease Relevance 1.02 Pain Relevance 0.16
Then, serum CRP level decreased rapidly, and cutaneous ulcer also improved.
Negative_regulation (decreased) of CRP associated with ulcers
3) Confidence 0.58 Published 2008 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 18446015 Disease Relevance 1.11 Pain Relevance 0.19
The data from patients with and without parenchymal involvement overlapped, the only difference being a higher prevalence of high CRP levels in cases with parenchymal involvement.
Negative_regulation (prevalence) of CRP
4) Confidence 0.42 Published 2008 Journal Int. J. Antimicrob. Agents Section Abstract Doc Link 18191385 Disease Relevance 0.94 Pain Relevance 0.30
The improvement in daily scores was accompanied by decreases in ESR, CRP and SAA levels.
Negative_regulation (decreases) of CRP
5) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.52 Pain Relevance 0.11
The effect of acute exercise on high sensitivity CRP has not been reported before, but exercise training has been shown to reduce levels of CRP [2,25].
Negative_regulation (reduce) of CRP
6) Confidence 0.28 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 1.08 Pain Relevance 0.86
Whereas significant reduction in BASDAI, ESR, and CRP were obvious after treatment, there was no significant change in serum level of p40 IL12/23.
Negative_regulation (reduction) of CRP
7) Confidence 0.28 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.51 Pain Relevance 0.28
At the higher doses, a statistically significant improvement was seen in the reduction of the ESR (p < 0.05), and a trend towards further improvement in CRP and SAA level reduction.
Negative_regulation (reduction) of CRP
8) Confidence 0.25 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.43 Pain Relevance 0.09
Over a three month period his symptoms resolved with a healing response on x-ray and with a reduced CRP.



Negative_regulation (reduced) of CRP
9) Confidence 0.16 Published 2001 Journal BMC Surg Section Abstract Doc Link PMC32179 Disease Relevance 0.56 Pain Relevance 0
It is also relevant that a similar low dose of insulin infusion causes a reduction of 40% in plasma CRP and SAA concentrations within 24 h in acutely ill patients with acute myocardial infarction (3) and in patients undergoing coronary artery bypass surgery (4).
Negative_regulation (reduction) of CRP in coronary artery associated with myocardial infarction
10) Confidence 0.13 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.89 Pain Relevance 0.28
Whether a significant part of this suppression of CRP and SAA and the cardioprotection observed in acute myocardial infarction receives a contribution from a reduction in TLR2 expression needs to be carefully assessed in the future.
Negative_regulation (suppression) of CRP associated with myocardial infarction
11) Confidence 0.13 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.94 Pain Relevance 0.23
Likewise, ATP and creatine phosphate (CrP) were reduced after 100 s, but the level of CrP was partially restored to initial values after 15 min.
Negative_regulation (reduced) of CrP
12) Confidence 0.11 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19625691 Disease Relevance 0.41 Pain Relevance 0.12
Serum amylase, lipase and CRP were significantly reduced in all treated groups.
Negative_regulation (reduced) of CRP
13) Confidence 0.03 Published 2003 Journal Pancreatology Section Body Doc Link 14631103 Disease Relevance 0 Pain Relevance 0

General Comments

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