INT110231

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.18
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
Bladder 10
neurons 2
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 100.00 Very High Very High Very High
dorsal root ganglion 104 99.68 Very High Very High Very High
Inflammation 171 97.62 Very High Very High Very High
chemokine 301 97.24 Very High Very High Very High
opiate 2 96.16 Very High Very High Very High
opioid receptor 3 93.20 High High
Neuropathic pain 40 93.12 High High
Demyelination 51 91.68 High High
cytokine 40 90.72 High High
glial activation 2 90.16 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 53 100.00 Very High Very High Very High
Injury 110 99.82 Very High Very High Very High
Ganglion Cysts 105 99.68 Very High Very High Very High
Hyperplasia 10 98.16 Very High Very High Very High
Disease Progression 2 98.00 Very High Very High Very High
INFLAMMATION 183 97.62 Very High Very High Very High
Nociception 28 96.80 Very High Very High Very High
Neuropathic Pain 54 93.68 High High
Demyelinating Disease 54 91.68 High High
Disease 20 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bladder CXCR4 mRNA expression, Western blotting and CXCR4-MIF co-immunoprecipitation
Regulation (immunoprecipitation) of Gene_expression (expression) of CXCR4 mRNA in Bladder
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Bladder CXCR4 mRNA expression, Western blotting and CXCR4-MIF co-immunoprecipitation
Regulation (Bladder) of Gene_expression (expression) of CXCR4 in Bladder
2) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
CYP treatment (aside from producing bladder inflammation and urothelial hyperplasia, well-described effects of cyclophosphamide in the bladder [24], [25]) also resulted in up-regulation of bladder CXCR4 mRNA and redistribution of CXCR4 to the entire urothelial area (including apical area of superficial cells previously devoid of CXCR4; Fig. 2D).
Regulation (regulation) of Gene_expression (redistribution) of CXCR4 in bladder associated with inflammation and hyperplasia
3) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.20 Pain Relevance 0.09
Bladder CXCR4 mRNA expression, Western blotting and CXCR4-MIF co-immunoprecipitation
Regulation (Bladder) of Gene_expression (expression) of CXCR4 mRNA in Bladder
4) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Bladder CXCR4 mRNA expression, Western blotting and CXCR4-MIF co-immunoprecipitation
Regulation (immunoprecipitation) of Gene_expression (expression) of CXCR4 in Bladder
5) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Upregulated CXCR4 expression, however, is primarily restricted to neurons making them a potential target for the release of SDF-1 from glia.
Regulation (neurons) of Gene_expression (expression) of CXCR4 in neurons
6) Confidence 0.35 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.60 Pain Relevance 0.59
Injury induced alteration of CXCR4 mRNA and protein expression in lumbar DRG
Regulation (alteration) of Gene_expression (expression) of CXCR4 mRNA associated with dorsal root ganglion and injury
7) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.49 Pain Relevance 0.36
The combination of a T-tropic form of gp120 with hCD4 did not alter the expression or functional signaling of SDF1/CXCR4 in the DRG, however, increased expression of both MCP1 and CCR2 was observed, in addition to increased functional signaling via CCR2.
Neg (not) Regulation (alter) of Gene_expression (expression) of CXCR4 associated with dorsal root ganglion
8) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.14 Pain Relevance 0.66
In the present report, we have investigated the effect of opioids on the expression of the major HIV-1 coreceptors CXCR4 and CCR5.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection and opioid
9) Confidence 0.15 Published 2003 Journal Virology Section Abstract Doc Link 12726730 Disease Relevance 0.75 Pain Relevance 0.74

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