INT110233

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 7.14
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR5) plasma membrane (CCR5) cell-cell signaling (CCR5)
cytoplasm (CCR5) signal transducer activity (CCR5)
Anatomy Link Frequency
T-cell 2
CCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 61 100.00 Very High Very High Very High
Opioid 16 100.00 Very High Very High Very High
Morphine 4 99.74 Very High Very High Very High
opiate 2 96.88 Very High Very High Very High
cytokine 8 95.48 Very High Very High Very High
opioid receptor 3 93.92 High High
MU agonist 1 89.04 High High
Pain 1 84.00 Quite High
antagonist 6 82.96 Quite High
analgesia 1 80.72 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 646 100.00 Very High Very High Very High
Adhesions 12 100.00 Very High Very High Very High
Infection 191 98.92 Very High Very High Very High
Disease Progression 10 98.00 Very High Very High Very High
Sprains And Strains 8 95.44 Very High Very High Very High
Aging 12 95.12 Very High Very High Very High
Pancreatic Cancer 5 87.72 High High
Constipation 4 86.56 High High
Cardiovascular Disease 7 81.28 Quite High
Disease 36 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biological effects of statins on cholesterol metabolism, Rho GTPases activity, LFA-1/ICAM-1 function and CCR5/RANTES expression can disrupt several steps of the HIV-1 life cycle, and target cell membrane interaction.
Regulation (effects) of Gene_expression (expression) of CCR5 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.34 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.89 Pain Relevance 0.03
Analysis of CD4 and CCR5 dependence
Regulation (Analysis) of Gene_expression (dependence) of CCR5 associated with addiction
2) Confidence 0.29 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.31 Pain Relevance 0.12
Furthermore, MNTX abolished morphine-mediated up-regulation of CCR5 receptor expression.
Regulation (regulation) of Gene_expression (expression) of CCR5 associated with morphine
3) Confidence 0.27 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14560041 Disease Relevance 1.44 Pain Relevance 1.60
CCR5 expression by MDCs was affected only post surgery (post: median 980, control: median 848) (Figure 5B).
Regulation (affected) of Gene_expression (expression) of CCR5
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.21 Pain Relevance 0.16
In the present report, we have investigated the effect of opioids on the expression of the major HIV-1 coreceptors CXCR4 and CCR5.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of CCR5 associated with acquired immune deficiency syndrome or hiv infection and opioid
5) Confidence 0.16 Published 2003 Journal Virology Section Abstract Doc Link 12726730 Disease Relevance 0.75 Pain Relevance 0.74
Finally, changes in T-cell receptor expression as a person ages, such as increased expression of the CCR5 co-receptor, is important in the pathogenesis of HIV infection and could also influence disease progression (Kalayjian et al 2003; Yung and Mo 2003).
Regulation (changes) of Gene_expression (expression) of CCR5 co-receptor in T-cell associated with acquired immune deficiency syndrome or hiv infection, disease progression and infection
6) Confidence 0.15 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 2.21 Pain Relevance 0
Moreover, some evidence suggests that statins alter the intracellular signals dependent on Rho GTPases [16], the functional activity of LFA-1/ICAM-1 adhesion molecules [17], the expression of the CCR5 coreceptor and the secretion of RANTES [18], and may exert significant modulatory effects on the balance of the cytokine network in human beings [19,20].
Regulation (dependent) of Gene_expression (expression) of CCR5 associated with adhesions and cytokine
7) Confidence 0.15 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.66 Pain Relevance 0.05
Moreover, some evidence suggests that statins alter the intracellular signals dependent on Rho GTPases [16], the functional activity of LFA-1/ICAM-1 adhesion molecules [17], the expression of the CCR5 coreceptor and the secretion of RANTES [18], and may exert significant modulatory effects on the balance of the cytokine network in human beings [19,20].
Spec (may) Regulation (alter) of Gene_expression (expression) of CCR5 associated with adhesions and cytokine
8) Confidence 0.15 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.67 Pain Relevance 0.05

General Comments

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