INT110240

Context Info Confidence 0.00 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.96 Pain Relevance 0.79

hydrolase activity, acting on glycosyl bonds (Lyz2) extracellular region (Lyz2) cytoplasm (Lyz2)

Lyz2 (Mus musculus)

Pain Link Frequency Relevance Heat Hyperalgesia 7 99.96 guanethidine 1 97.08 antagonist 2 89.20 bradykinin 1 88.20 Serotonin 1 84.84 algogenic 1 59.76

Disease Link Frequency Relevance Heat Hyperalgesia 9 99.96 Nociception 2 98.28 Necrosis 1 90.96 Cancer 1 90.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pretreatment with guanethidine, atenolol, prazosin and yohimbine, inhibitors of sympathomimetic amines, or with indomethacin, inhibitor of the cyclo-oxygenase pathway, reduced Lys49 PLA(2)-induced hyperalgesia without interfering with the nociceptive activity of Asp49 PLA(2).

Positive_regulation (-induced) of Lys49 associated with nociception, hyperalgesia and guanethidine

1) Confidence 0.00 Published 2003 Journal Toxicon Section Abstract Doc Link 12727271 Disease Relevance 0.96 Pain Relevance 0.79

General Comments

This test has worked.