INT110242

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.72
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Syp)
Anatomy Link Frequency
cerebral cortex 1
brain 1
synapses 1
hippocampus 1
Syp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 5 100.00 Very High Very High Very High
amygdala 147 99.84 Very High Very High Very High
Thalamus 2 99.62 Very High Very High Very High
cerebral cortex 1 99.28 Very High Very High Very High
Hippocampus 8 97.88 Very High Very High Very High
anesthesia 6 97.44 Very High Very High Very High
fluoxetine 5 96.92 Very High Very High Very High
isoflurane 1 92.88 High High
Versed 1 89.00 High High
Spinal cord 17 87.16 High High
Disease Link Frequency Relevance Heat
Stress 7 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
Anxiety Disorder 76 99.46 Very High Very High Very High
Body Weight 4 95.52 Very High Very High Very High
Adhesions 4 91.16 High High
Disease 2 72.24 Quite High
Apoptosis 3 58.52 Quite High
Shock 20 41.52 Quite Low
Death 3 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that venlafaxine and imipramine, but not fluoxetine, induce neuroplastic effects in the hippocampus through stimulation of BDNF mRNA expression, and that the effect on BDNF is not directly translated into regulation of synaptophysin and GAP-43 mRNA.
Regulation (regulation) of synaptophysin in hippocampus associated with hippocampus and fluoxetine
1) Confidence 0.32 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.53
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Regulation (modulating) of synaptophysin in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
2) Confidence 0.26 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.15 Pain Relevance 0.53
Auditory fear conditioning persistently regulates the expression of the postsynaptically- localized protein GluR1 and the presynaptically-localized proteins synapsin and synaptophysin at LA synapses
Regulation (regulates) of synaptophysin in synapses associated with anxiety disorder and amygdala
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.41 Pain Relevance 0.46
There were no significant changes in behavioral pain thresholds, circulating corticosterone concentrations (after acute immobilization stress) or NCAM and synaptophysin levels in various brain regions by the diet treatments.
Neg (no) Regulation (changes) of synaptophysin in brain associated with stress and pain
4) Confidence 0.15 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12727319 Disease Relevance 1.16 Pain Relevance 0.36
Therefore, the overlap of synaptophysin and NR1-immunoreactivities is assumed to indicate postsynaptic localization of NR1 subunits whereas extrasynaptic NR1 immunoreactivity appears independent of synaptophysin immunoreactivity.
Spec (appears) Regulation (immunoreactivity) of synaptophysin
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.07

General Comments

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