INT110244

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.66
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SNCA) oxidoreductase activity (SNCA) cell death (SNCA)
extracellular region (SNCA) histone binding (SNCA) plasma membrane (SNCA)
Anatomy Link Frequency
SK-N-MC 2
SNCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 5 99.24 Very High Very High Very High
Dopamine 45 98.94 Very High Very High Very High
induced neuropathy 2 97.72 Very High Very High Very High
Substantia nigra 34 91.12 High High
midbrain 12 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 273 100.00 Very High Very High Very High
Alzheimer's Dementia 36 100.00 Very High Very High Very High
Neuroblastoma 4 99.62 Very High Very High Very High
Neurodegenerative Disease 33 98.28 Very High Very High Very High
Neuropathic Pain 2 97.72 Very High Very High Very High
Stress 7 97.32 Very High Very High Very High
Parkinson's Disease 317 96.60 Very High Very High Very High
Drug Induced Neurotoxicity 2 89.92 High High
Dementia 126 89.84 High High
Multiple System Atrophy 3 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants.
Positive_regulation (transfected) of Gene_expression (transfected) of alpha-synuclein associated with neuroblastoma, dopamine and disease
1) Confidence 0.69 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12727333 Disease Relevance 0.70 Pain Relevance 0.21
SK-N-MC neuroblastoma cells were transiently transfected with either wt alpha-synuclein, or its mutants, and their abilities to protect against oxidative stress were assessed.
Positive_regulation (transfected) of Gene_expression (transfected) of alpha-synuclein in SK-N-MC associated with stress and neuroblastoma
2) Confidence 0.50 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12727333 Disease Relevance 0.63 Pain Relevance 0.21
Similarly, mutations in the SNCA, or Synuclein-Alpha (non-A4 component of amyloid precursor) gene [40] as well as the overproduction of ?
Positive_regulation (overproduction) of Gene_expression (overproduction) of Synuclein-Alpha associated with alzheimer's dementia
3) Confidence 0.50 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 0.66 Pain Relevance 0
Using three independent and established neurodegenerative models in C. elegans, we assayed for acetaminophen-dependent rescue in response to: (1) over-expression of the PD-associated protein, alpha-synuclein; (2) acute exposure to 6-hydroxydopamine (6-OHDA); (3) excess intracellular DA production due to over-expression of the DA biosynthetic enzyme, tyrosine hydroxylase (TH).
Positive_regulation (over-expression) of Gene_expression (over-expression) of alpha-synuclein associated with dopamine, paracetamol, disease and neurodegenerative disease
4) Confidence 0.45 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18514411 Disease Relevance 0.84 Pain Relevance 0.72
-synuclein gene (SNCA) and increased expression of wild-type ?
Positive_regulation (increased) of Gene_expression (expression) of SNCA
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920329 Disease Relevance 1.17 Pain Relevance 0.05
Similarly, mutations in the SNCA, or Synuclein-Alpha (non-A4 component of amyloid precursor) gene [40] as well as the overproduction of ?
Positive_regulation (overproduction) of Gene_expression (overproduction) of SNCA associated with alzheimer's dementia
6) Confidence 0.44 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 0.66 Pain Relevance 0

General Comments

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