INT110252

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 6.36
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
Anatomy Link Frequency
proximal 2
nucleus 2
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 111 98.52 Very High Very High Very High
cytokine 137 92.32 High High
cINOD 10 86.04 High High
Kinase C 14 84.24 Quite High
Inflammatory marker 6 82.40 Quite High
Inflammation 227 71.08 Quite High
aspirin 58 61.64 Quite High
Inflammatory response 21 55.68 Quite High
dexamethasone 21 48.84 Quite Low
Inflammatory stimuli 4 43.44 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 38 99.60 Very High Very High Very High
Adhesions 163 96.68 Very High Very High Very High
Skin Cancer 5 96.32 Very High Very High Very High
Melanoma 2 95.08 Very High Very High Very High
Cancer 102 94.36 High High
Premature Aging 2 93.16 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 142 92.36 High High
Burns 4 91.96 High High
Hyperglycemia 40 90.88 High High
INFLAMMATION 276 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Positive_regulation (measure) of Gene_expression (expression) of p65
1) Confidence 0.49 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
M/mL and 116, 129, and 107% after incubation with antisense RelA p65 oligonucleotides in a concentration of 10, 20, and 30 ?
Positive_regulation (antisense) of Gene_expression (oligonucleotides) of p65
2) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Furthermore in HCPSMC no inhibitory effect was found after selective addition of antisense RelA p65 or NF-?
Positive_regulation (antisense) of Gene_expression (addition) of p65
3) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.05 Pain Relevance 0.03
M/mL and 116, 129, and 107% after incubation with antisense RelA p65 oligonucleotides in a concentration of 10, 20, and 30 ?
Positive_regulation (antisense) of Gene_expression (oligonucleotides) of RelA
4) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
The expression of ICAM-1 was 65, 74, and 74% after incubation with antisense RelA p65 oligonucleotides in a concentration of 1, 2, and 4 × ?
Positive_regulation (incubation) of Gene_expression (oligonucleotides) of p65
5) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
However the superiority of the combined therapy was demonstrated by the fact that the inhibitory potential was almost doubled after the simultaneous therapy with RelA p65 and NF-?
Positive_regulation (simultaneous) of Gene_expression (therapy) of RelA
6) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.07 Pain Relevance 0
The expression of ICAM-1 was 132, 129, and 113% after incubation with antisense p65 oligonucleotides in a concentration of 1, 2, and 4 ?
Positive_regulation (incubation) of Gene_expression (oligonucleotides) of p65
7) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Furthermore in HCPSMC no inhibitory effect was found after selective addition of antisense RelA p65 or NF-?
Positive_regulation (antisense) of Gene_expression (addition) of RelA
8) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.05 Pain Relevance 0.03
After adding simultaneously antisense RelA p65 and NF-?
Positive_regulation (simultaneously) of Gene_expression (antisense) of RelA
9) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.10 Pain Relevance 0
However the superiority of the combined therapy was demonstrated by the fact that the inhibitory potential was almost doubled after the simultaneous therapy with RelA p65 and NF-?
Positive_regulation (with) of Gene_expression (therapy) of p65
10) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.07 Pain Relevance 0
The expression of ICAM-1 was 65, 74, and 74% after incubation with antisense RelA p65 oligonucleotides in a concentration of 1, 2, and 4 × ?
Positive_regulation (antisense) of Gene_expression (oligonucleotides) of p65
11) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
The inhibition of ICAM-1 expression in HUVEC and HCAEC after simultaneous addition of antisense RelA p65 and NF-?
Positive_regulation (antisense) of Gene_expression (addition) of p65
12) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.07 Pain Relevance 0
The inhibition of ICAM-1 expression in HUVEC and HCAEC after simultaneous addition of antisense RelA p65 and NF-?
Positive_regulation (antisense) of Gene_expression (addition) of RelA
13) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.07 Pain Relevance 0
No inhibitory effect was seen after selective addition of antisense RelA p65 and NF-?
Positive_regulation (antisense) of Gene_expression (addition) of RelA
14) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.06 Pain Relevance 0
However the superiority of the combined therapy was demonstrated by the fact that the inhibitory potential was almost doubled after the simultaneous therapy with RelA p65 and NF-?
Positive_regulation (with) of Gene_expression (therapy) of RelA
15) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.07 Pain Relevance 0
The expression of ICAM-1 was 65, 74, and 74% after incubation with antisense RelA p65 oligonucleotides in a concentration of 1, 2, and 4 × ?
Positive_regulation (antisense) of Gene_expression (oligonucleotides) of RelA
16) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
After adding simultaneously antisense RelA p65 and NF-?
Positive_regulation (antisense) of Gene_expression (antisense) of RelA
17) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.10 Pain Relevance 0
However the superiority of the combined therapy was demonstrated by the fact that the inhibitory potential was almost doubled after the simultaneous therapy with RelA p65 and NF-?
Positive_regulation (simultaneous) of Gene_expression (therapy) of p65
18) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.07 Pain Relevance 0
The expression of ICAM-1 was 65, 74, and 74% after incubation with antisense RelA p65 oligonucleotides in a concentration of 1, 2, and 4 × ?
Positive_regulation (incubation) of Gene_expression (oligonucleotides) of RelA
19) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
No inhibitory effect was seen after selective addition of antisense RelA p65 and NF-?
Positive_regulation (antisense) of Gene_expression (addition) of p65
20) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.06 Pain Relevance 0

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