INT110259

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.30
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf)
Anatomy Link Frequency
skin 1
Vwf (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 5 99.90 Very High Very High Very High
substance P 5 98.58 Very High Very High Very High
Paracetamol 5 95.54 Very High Very High Very High
Inflammation 17 91.52 High High
Neuropeptide 1 81.48 Quite High
bradykinin 1 73.76 Quite High
Neurotransmitter 3 64.80 Quite High
Pain 5 58.72 Quite High
pruritus 1 58.36 Quite High
Bioavailability 2 30.64 Quite Low
Disease Link Frequency Relevance Heat
Thrombotic Thrombocytopenic Purpura 2 98.02 Very High Very High Very High
Acute Liver Failure 8 97.54 Very High Very High Very High
Cicatrix 5 97.32 Very High Very High Very High
Adhesions 19 94.76 High High
Disease 27 92.48 High High
INFLAMMATION 25 91.52 High High
Injury 7 91.48 High High
Thrombocytopenia 6 89.60 High High
Coagulation Disorder 3 88.40 High High
Natriuresis 1 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The density of PGP9.5, CGRP, SP and VWF peaked between 14 and 42 days, and levels of PGP9.5, CGRP and VWF all decreased to approximately those found in unwounded skin by 84 days (mature scar).
Negative_regulation (decreased) of VWF in skin associated with calcitonin gene related peptide, cicatrix and substance p
1) Confidence 0.42 Published 2006 Journal Journal of plastic, reconstructive & aesthetic surgery : JPRAS Section Abstract Doc Link 16920586 Disease Relevance 0.92 Pain Relevance 0.64
A similar downregulation of vWF at the 24-hour
Negative_regulation (downregulation) of vWF
2) Confidence 0.20 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0
However, acetaminophen-treated mice demonstrated markedly reduced fVIII activity, contrary to the observation in human FHF. von Willebrand factor antigen levels were only mildly reduced, suggesting that the decrease in fVIII is not secondary to loss of von Willebrand factor.
Negative_regulation (loss) of von Willebrand factor associated with paracetamol and acute liver failure
3) Confidence 0.18 Published 2003 Journal Blood Section Abstract Doc Link 12730105 Disease Relevance 0.72 Pain Relevance 0.34
Similarly, investigations of ADAMTS-13 proteins revealed that the major epitopes of inhibitory autoantibodies from patients with thrombotic thrombocytopenic purpura reside within the CRD-spacer region and that removal of the CRD-spacer region results in a marked reduction in vWF cleaving activity [86].
Negative_regulation (reduction) of vWF associated with thrombotic thrombocytopenic purpura
4) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.10 Pain Relevance 0
Modulation of hemostasis includes the release of plasminogen activator, tissue factor inhibitor, von Willebrand factor, NO, prostacyclin, TXA2, plasminogen-activator inhibitor-1 (PAI-1), and fibrinogen.
Negative_regulation (inhibitor) of von Willebrand factor
5) Confidence 0.10 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.88 Pain Relevance 0.12
The mechanism inducing the pathology has not been elucidated, but vWF is downregulated, without dose effect correlation, and the pathology is reversible following treatment, or can be corrected by desmopressin.
Negative_regulation (downregulated) of vWF
6) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.67 Pain Relevance 0

General Comments

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