INT110261

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.33
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8)
Anatomy Link Frequency
hepatocytes 2
Adipose tissue 2
F8 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 97.16 Very High Very High Very High
Inflammation 2 84.88 Quite High
Paracetamol 4 83.60 Quite High
antagonist 1 39.68 Quite Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombophilia 1 99.26 Very High Very High Very High
Obesity 29 97.30 Very High Very High Very High
Cancer 1 96.72 Very High Very High Very High
Necrosis 1 96.48 Very High Very High Very High
Acute Liver Failure 8 92.80 High High
INFLAMMATION 2 84.88 Quite High
Insulin Resistance 5 84.48 Quite High
Overdose 1 82.48 Quite High
Metabolic Syndrome 52 75.20 Quite High
Diabetes Mellitus 5 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concurrently, factor VIII (fVIII) procoagulant activity rises despite destruction of the hepatocytes considered responsible for fVIII synthesis.
Regulation (responsible) of Gene_expression (synthesis) of fVIII in hepatocytes
1) Confidence 0.61 Published 2003 Journal Blood Section Abstract Doc Link 12730105 Disease Relevance 0.73 Pain Relevance 0.31
Adipose tissue may contribute to enhanced coagulation by direct tissue factor production, but hypercoagulability is likely to be primarily caused by altered hepatic synthesis of the coagulation factors fibrinogen, factor VII, factor VIII, and tissue factor, by releasing free fatty acids and proinflammatory cytokines (tumor necrosis factor-?
Regulation (altered) of Gene_expression (synthesis) of factor VIII in Adipose tissue associated with necrosis, cancer, thrombophilia, obesity and cytokine
2) Confidence 0.00 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3014711 Disease Relevance 1.60 Pain Relevance 0.09

General Comments

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