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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.10
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabbr1) transcription factor binding (Gabbr1) cytoplasm (Gabbr1)
signal transducer activity (Gabbr1)
Gabbr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 18 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
rheumatoid arthritis 29 98.80 Very High Very High Very High
Trigeminal neuralgia 2 98.72 Very High Very High Very High
tolerance 3 98.00 Very High Very High Very High
antiallodynic 4 96.96 Very High Very High Very High
Morphine 3 94.96 High High
allodynia 5 89.64 High High
Multiple sclerosis 3 83.04 Quite High
Neuropathic pain 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Genetic Predisposition To Disease 2 99.84 Very High Very High Very High
Rheumatoid Arthritis 29 98.80 Very High Very High Very High
Headache 2 98.72 Very High Very High Very High
Neuropathic Pain 7 89.64 High High
Nociception 3 88.64 High High
Epilepsy 1 85.52 High High
Sleep Disorders 1 85.12 High High
Schizophrenia 1 84.64 Quite High
Disease 10 84.04 Quite High
Myasthenia Gravis 3 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GABA-B receptor agonist baclofen (1.06 mg/day) that has a recognized usefulness in the treatment of trigeminal neuralgia, demonstrated effectiveness in both conditions.
GABA-B receptor Binding (recognized) of associated with gaba, trigeminal neuralgia and agonist
1) Confidence 0.36 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730352 Disease Relevance 0.81 Pain Relevance 1.60
Thus, observed genetic association to this region suggests a potentially independent role for GABBR1 in genetic susceptibility to RA.
GABBR1 Binding (association) of associated with genetic predisposition to disease and rheumatoid arthritis
2) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.29 Pain Relevance 0.58

General Comments

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