INT110278

Context Info Confidence 0.32 First Reported 2003 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.35 Pain Relevance 0.47

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1) endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)

Anatomy Link Frequency NG108-15 1 brain 1 Sigmar1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 2 99.54 fortral 10 98.78 antagonist 1 93.44 cocaine 3 70.36 tolerance 1 29.80 Pain 1 29.40 opioid receptor 1 18.96 potassium channel 6 5.00

Disease Link Frequency Relevance Heat Cancer 2 99.04 Adhesions 10 90.32 Metastasis 2 83.44 Attention Deficit Hyperactivity Disorder 1 32.04 Pain 1 29.40 Psychosis 1 29.04 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mice that were administered an antisense oligodeoxynucleotide to down-regulate brain sigma1 receptors also exhibited a reduced locomotor stimulatory response to methamphetamine, as compared to control mice receiving mismatch oligonucleotides.

Negative_regulation (down-regulate) of sigma1 in brain

1) Confidence 0.32 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15939443 Disease Relevance 0 Pain Relevance 0.13

Additionally, cancer cell lines have been shown to be significantly enriched with sigma-1 receptors[20].

Negative_regulation (enriched) of sigma-1 associated with cancer

2) Confidence 0.27 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.35 Pain Relevance 0.06

By combining immunocytochemistry and real-time monitoring of enhanced yellow fluorescent protein (EYFP)-tagged sigma-1 receptors (Sig-1R-EYFP) in living cells, we characterized the sigma-1 receptor translocation in this study. (+)-Pentazocine, a selective sigma-1 receptor agonist, causes a significant decrease of sigma-1 receptors in ER-LDs and a diffused distribution of sigma-1 receptors over the entire endoplasmic reticulum reticular network in NG108-15 cells.

Negative_regulation (decrease) of sigma-1 in NG108-15 associated with fortral and agonist

3) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730356 Disease Relevance 0 Pain Relevance 0.28

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