INT110278

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.35
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
NG108-15 1
brain 1
Sigmar1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 99.54 Very High Very High Very High
fortral 10 98.78 Very High Very High Very High
antagonist 1 93.44 High High
cocaine 3 70.36 Quite High
tolerance 1 29.80 Quite Low
Pain 1 29.40 Quite Low
opioid receptor 1 18.96 Low Low
potassium channel 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2 99.04 Very High Very High Very High
Adhesions 10 90.32 High High
Metastasis 2 83.44 Quite High
Attention Deficit Hyperactivity Disorder 1 32.04 Quite Low
Pain 1 29.40 Quite Low
Psychosis 1 29.04 Quite Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice that were administered an antisense oligodeoxynucleotide to down-regulate brain sigma1 receptors also exhibited a reduced locomotor stimulatory response to methamphetamine, as compared to control mice receiving mismatch oligonucleotides.
Negative_regulation (down-regulate) of sigma1 in brain
1) Confidence 0.32 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15939443 Disease Relevance 0 Pain Relevance 0.13
Additionally, cancer cell lines have been shown to be significantly enriched with sigma-1 receptors[20].
Negative_regulation (enriched) of sigma-1 associated with cancer
2) Confidence 0.27 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.35 Pain Relevance 0.06
By combining immunocytochemistry and real-time monitoring of enhanced yellow fluorescent protein (EYFP)-tagged sigma-1 receptors (Sig-1R-EYFP) in living cells, we characterized the sigma-1 receptor translocation in this study. (+)-Pentazocine, a selective sigma-1 receptor agonist, causes a significant decrease of sigma-1 receptors in ER-LDs and a diffused distribution of sigma-1 receptors over the entire endoplasmic reticulum reticular network in NG108-15 cells.
Negative_regulation (decrease) of sigma-1 in NG108-15 associated with fortral and agonist
3) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730356 Disease Relevance 0 Pain Relevance 0.28

General Comments

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