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Context Info
Confidence 0.24
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.47
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CNDP2) peptidase activity (CNDP2) small molecule metabolic process (CNDP2)
cellular nitrogen compound metabolic process (CNDP2) cytoplasm (CNDP2)
Anatomy Link Frequency
extracellular matrix 1
Rat2 1
CNDP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 1 98.56 Very High Very High Very High
Enkephalin 7 93.56 High High
depression 27 91.68 High High
antidepressant 3 69.20 Quite High
substance P 2 62.20 Quite High
metalloproteinase 4 62.00 Quite High
Inflammation 31 51.24 Quite High
Opioid 5 49.20 Quite Low
Dopamine 1 40.40 Quite Low
Morphine 1 29.28 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 98 100.00 Very High Very High Very High
Renal Cancer 39 95.08 Very High Very High Very High
Cancer 68 93.40 High High
Natriuresis 2 92.56 High High
Depression 36 91.68 High High
Prostate Cancer 1 88.20 High High
Endometriosis (extended) 1 87.08 High High
Lung Cancer 1 85.96 High High
Adenocarcinoma 1 84.08 Quite High
Bladder Cancer 1 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The peptidase recognizes the N-terminal sequence of various endogenous opioid peptides.
peptidase Binding (recognizes) of associated with endogenous opioid
1) Confidence 0.24 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3037971 Disease Relevance 0 Pain Relevance 0.35
Different families may have a different sets of dysfunctional enzymes probably peptidases or peptidase binding proteins.
peptidase Binding (binding) of
2) Confidence 0.14 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC2063501 Disease Relevance 0.56 Pain Relevance 0.30
It is accepted that the interactions of this membrane-bound peptidase with other transmembrane proteins and/or the extracellular matrix (ECM) may have similar or even more relevance in regulating cells than cleaving bioactive peptides [7].
peptidase Binding (interactions) of in extracellular matrix
3) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 1.49 Pain Relevance 0
Senescent cells showed significant downregulation of three genes related to apoptosis: BCL2/adenovirus E1B interacting proteins 2 and 3, and apoptotic peptidase activating factor 1.
peptidase Binding (interacting) of associated with apoptosis
4) Confidence 0.04 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.30 Pain Relevance 0.06
Only four antibodies cross-reacted with the peptidase from the rat epithelial cell line Rat2, as shown by membrane immunofluorescence, and these also partially inhibited enzyme activity.
peptidase Binding (reacted) of in Rat2
5) Confidence 0.01 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1531755 Disease Relevance 0.31 Pain Relevance 0.16
Once cytochrome C is released into the cytosol, it interacts with apoptotic peptidase activating factor-1 (APAF-1) and this leads to the recruitment of procaspase 9 into a multiprotein complex called the apoptosome.
peptidase Binding (interacts) of associated with apoptosis
6) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.80 Pain Relevance 0

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