INT110284

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.08
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
arm 2
brain 2
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 8 99.80 Very High Very High Very High
5HT 8 99.68 Very High Very High Very High
antagonist 3 99.04 Very High Very High Very High
agonist 3 96.80 Very High Very High Very High
dexamethasone 4 96.12 Very High Very High Very High
amygdala 6 94.32 High High
antidepressant 6 92.44 High High
noradrenaline 5 86.40 High High
Serotonin 1 85.28 High High
monoamine 2 83.32 Quite High
Disease Link Frequency Relevance Heat
Death 3 98.88 Very High Very High Very High
Anxiety Disorder 14 97.52 Very High Very High Very High
Stress 59 96.76 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 86.16 High High
Attention Deficit Hyperactivity Disorder 3 75.48 Quite High
Pain 3 75.00 Quite High
Decapitation 1 65.80 Quite High
Post-traumatic Stress Disorder 27 65.24 Quite High
Depression 3 64.64 Quite High
Functional Bowel Disorder 1 63.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine exposure prevents up-regulation of MR and GR binding sites in the brain of adult male and female rats due to prenatal stress.
Negative_regulation (prevents) of Positive_regulation (up-regulation) of MR in brain associated with stress and morphine
1) Confidence 0.53 Published 2006 Journal Int. J. Dev. Neurosci. Section Title Doc Link 16698219 Disease Relevance 0.32 Pain Relevance 0.47
A previous study showed that the activation of MR or GR blocked adrenalectomy-induced cell death.
Negative_regulation (blocked) of Positive_regulation (activation) of MR associated with death
2) Confidence 0.41 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.59 Pain Relevance 0.24
Our results showed that GR or MR activation significantly reduced open arm exploration on the elevated plus maze, a measure of anxiety-like behavior.
Negative_regulation (reduced) of Positive_regulation (activation) of MR in arm associated with anxiety disorder
3) Confidence 0.32 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19875699 Disease Relevance 0.66 Pain Relevance 0.84
The induction of mineralocorticoid receptor mRNA was completely blocked by the 5HT(7) receptor antagonist SB 269970.
Negative_regulation (blocked) of Positive_regulation (induction) of mineralocorticoid receptor associated with antagonist and 5ht
4) Confidence 0.03 Published 2003 Journal Neuroscience Section Abstract Doc Link 12732243 Disease Relevance 0.20 Pain Relevance 0.94

General Comments

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