INT11030

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1992
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 70
Total Number 74
Disease Relevance 40.35
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LPA) transport (LPA) small molecule metabolic process (LPA)
extracellular region (LPA) lipid metabolic process (LPA)
Anatomy Link Frequency
heart 6
plasma 3
midgut 3
coronary artery 2
endothelial cells 2
LPA (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 164 100.00 Very High Very High Very High
Multiple sclerosis 82 99.62 Very High Very High Very High
Angina 187 99.34 Very High Very High Very High
drug abuse 1 98.88 Very High Very High Very High
addiction 6 98.64 Very High Very High Very High
agonist 150 97.12 Very High Very High Very High
aspirin 162 96.96 Very High Very High Very High
antagonist 12 96.60 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 5 93.84 High High
adenocard 10 92.56 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 678 100.00 Very High Very High Very High
Obesity 406 100.00 Very High Very High Very High
Rheumatoid Arthritis 168 100.00 Very High Very High Very High
Diabetes Mellitus-type I 36 100.00 Very High Very High Very High
Coronary Artery Disease 533 99.98 Very High Very High Very High
Atherosclerotic Plaque 4 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 11 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 58 99.76 Very High Very High Very High
Acute-phase Reaction 5 99.76 Very High Very High Very High
Myocardial Infarction 457 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reason why Lp(a) was only associated with MACE in patients in high Killip classes remains unclear.
Lp Binding (associated) of
1) Confidence 0.48 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.54 Pain Relevance 0
In the NHANES-III study, no association of Lp(a) were seen with family history of stroke, hypertension, or diabetes.
Lp Binding (association) of associated with diabetes mellitus, stroke and hypertension
2) Confidence 0.46 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 1.20 Pain Relevance 0.05
Few studies of the association of Lp(a) with family history have been reported in children [30,39].
Lp Binding (association) of
3) Confidence 0.46 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.31 Pain Relevance 0.09
Altogether, our observation from the present NHANES-III study, together with the work of others [30,38] found very few significant associations of Lp(a) with personal, behavioral, or environmental variables.
Lp Binding (associations) of
4) Confidence 0.46 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.13 Pain Relevance 0.06
However, contrary to Bogalusa study showing an association of Lp(a) with parental history of hypercholesterolemia, trends for family history in black children in NHANES-III were concordant with those in whites, although not attaining statistical significance.
Lp Binding (association) of associated with hyperlipidemia
5) Confidence 0.46 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.57 Pain Relevance 0.09
Kendall's nonparametric rank correlation was used to assess the association of Lp(a) with other variables and compared to Pearson correlation [22].
Lp Binding (association) of
6) Confidence 0.46 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.28 Pain Relevance 0
To analyze the association between serum Lp(a) levels and clinical outcomes, the Cox proportional hazards model was applied with adjustment of multiple variables.
Lp Spec (analyze) Binding (association) of
7) Confidence 0.42 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.25 Pain Relevance 0
Conversely, several reports indicate an association between IDDM with Lp(a) [29,41].
Lp Binding (association) of associated with diabetes mellitus-type i
8) Confidence 0.40 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 1.24 Pain Relevance 0
Basically, Lp(a) is not easily modified by statin therapy.14) Although there are contradictory findings about the effect of statins on Lp(a) serum concentrations,15) it is uncertain whether statin use prevents the coronary heart disease associated with Lp(a).16) Nearly 80% of patients in our study were administered statins, and since the numbers of patients taking statins were almost equally distributed among the tertiles, statin therapy probably did not influence our results.
Lp Binding (associated) of in heart associated with coronary artery disease
9) Confidence 0.37 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.64 Pain Relevance 0.04
A number of prospective and retrospective studies have demonstrated that increased levels of Lp(a) are associated with atherosclerosis, ischemic heart disease, and stroke.5)6) In numerous trials, patients with high Lp(a) levels had markedly increased risk of coronary heart disease.7-9) However, the relationship between Lp(a) levels and outcomes after acute myocardial infarction (AMI) is unclear.
Lp Binding (associated) of in heart associated with coronary artery disease, stroke, increased venous pressure under development and myocardial infarction
10) Confidence 0.36 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 1.02 Pain Relevance 0
Lipoprotein(a) {Lp(a)} consists of a low-density lipoprotein particle covalently bound to a specific glycoprotein, apolipoprotein(a), by apolipoprotein B-100.1) Since apolipoprotein(a) and plasminogen mutually compete for plasminogen receptors on endothelial cells,2) high concentrations of circulating Lp(a) may inhibit thrombolysis and fibrin clearance.3) Moreover, the binding of native Lp(a) to fibrin is significantly enhanced in the presence of homocysteine, glutathione, and cysteine.4)
Lp Binding (binding) of in endothelial cells associated with disorder of lipid metabolism
11) Confidence 0.36 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.81 Pain Relevance 0
Lipoprotein(a) {Lp(a)} consists of a low-density lipoprotein particle covalently bound to a specific glycoprotein, apolipoprotein(a), by apolipoprotein B-100.1) Since apolipoprotein(a) and plasminogen mutually compete for plasminogen receptors on endothelial cells,2) high concentrations of circulating Lp(a) may inhibit thrombolysis and fibrin clearance.3) Moreover, the binding of native Lp(a) to fibrin is significantly enhanced in the presence of homocysteine, glutathione, and cysteine.4)
apolipoprotein Binding (bound) of in endothelial cells associated with disorder of lipid metabolism
12) Confidence 0.36 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.62 Pain Relevance 0
Parental history of heart attack/angina before age 50 was significantly associated with Lp(a) >30 after controlling for age and sex both in white children (beta -1.14, SE 0.55, P = 0.04) and in blacks (beta -0.80, SE 0.39, P = 0.05).
Lp Binding (associated) of in heart associated with angina and myocardial infarction
13) Confidence 0.36 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.62 Pain Relevance 0.19
However, this result should be considered with caution, since stepwise regression analysis did not confirm an independent association between Lp(a) levels and CHD in our sample of overweight subjects.
Lp Binding (association) of associated with coronary artery disease and overweight
14) Confidence 0.35 Published 2003 Journal BMC Cardiovasc Disord Section Body Doc Link PMC327094 Disease Relevance 1.11 Pain Relevance 0.03
The Xenopus laevis homolog of this receptor binds LPA [55].
LPA Binding (binds) of
15) Confidence 0.35 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.20
The most important findings of this study are that ethnicity significantly associated with Lp(a), and that parental history of heart attack significantly associated with Lp(a) levels >= 30 mg/dl.
Lp Binding (associated) of in heart associated with myocardial infarction
16) Confidence 0.34 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.39 Pain Relevance 0
However, no such collective consistent associations of Lp(a) were found with age, gender, or birth weight.


Lp Binding (associations) of associated with birth weight
17) Confidence 0.34 Published 2004 Journal Lipids Health Dis Section Abstract Doc Link PMC544891 Disease Relevance 0.70 Pain Relevance 0.17
Associations of Lp(a) with other variables were confirmed in final weighted analysis, using PROC LOGIST procedure in SUDAAN [23] with alpha set at <0.05.
Lp Binding (Associations) of
18) Confidence 0.34 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0 Pain Relevance 0
However, no study has examined whether the effects of inherited and acquired or environmental factors interact with Lp(a) > 30 mg/dl, to cause differential attributable risk in different populations using data from a nationally representative sample of children in the US.
Lp Binding (interact) of
19) Confidence 0.34 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.65 Pain Relevance 0
In the entire group, total cholesterol (which included Lp(a)) and parental history of premature heart attack/angina before age 50 (P < 0.02) showed consistent, independent, positive association with Lp(a).
Lp Binding (association) of in heart associated with angina, myocardial infarction and disorder of lipid metabolism
20) Confidence 0.34 Published 2004 Journal Lipids Health Dis Section Abstract Doc Link PMC544891 Disease Relevance 0.70 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox