INT110315

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5) small molecule metabolic process (ALOX5) intracellular (TNF)
extracellular matrix organization (TNF) cytoplasm (ALOX5) cytosol (ALOX5)
ALOX5 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 99.84 Very High Very High Very High
Inflammation 5 98.48 Very High Very High Very High
cINOD 12 86.08 High High
COX-2 inhibitor 1 75.00 Quite High
Pain 2 67.72 Quite High
Arthritis 1 49.32 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 98.48 Very High Very High Very High
Pain 1 67.72 Quite High
Toxicity 3 58.24 Quite High
Rheumatic Diseases 2 52.32 Quite High
Arthritis 1 49.32 Quite Low
Injury 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The products generated by the 5-lipoxygenase pathway (leukotrienes) are particularly important in inflammation: indeed, leukotrienes increase microvascular permeability and are potent chemotactic agents; moreover, inhibition of 5-lipoxygenase indirectly reduces the expression of TNF-alpha (a cytokine that plays a key role in inflammation).
Negative_regulation (inhibition) of 5-lipoxygenase Negative_regulation (reduces) of Gene_expression (expression) of TNF-alpha associated with inflammation and cytokine
1) Confidence 0.47 Published 2002 Journal Curr. Med. Chem. Section Abstract Doc Link 12733982 Disease Relevance 0.74 Pain Relevance 0.85

General Comments

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